CAS: 52387-14-1; (R)-1-(5,8-Dihydroxy-1,4-Dioxo-1,4-Dihydronaphthalen-2-yl)-4-Methylpent-3-En-1-Yl 3-Methylbutanoate
该化合物是天然的环烷磺酮衍生物,产自Lithospermum 红血素及相关物种的根部,该化合物显示出显著的生物活动,包括抗微生物,抗炎和抗直肠特性,原因是它能够调节细胞红氧化工艺,抑制关键的酶酶途径.其亲脂性能提高了膜渗透性,使它成为药物和化妆品应用的有前途的候选产品.还研究了Isovalerylshikonin在创伤愈合方面的潜力,以及因其选择性地对癌症细胞产生细胞细胞毒性而成为一种乳腺化疗养辅助剂.在研究中,利用高纯度隔离物来调查其行动和治疗效果机制.
- 英文名称(R)-1-(5,8-Dihydroxy-1,4-Dioxo-1,4-Dihydronaphthalen-2-yl)-4-Methylpent-3-En-1-Yl 3-Methylbutanoate
- 中文名称异戊酰紫草素
- IUPAC名称(R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 3-methylbutanoate
- 其它别名3-Methylbutanoic Acid (R)-1-[(1,4-Dioxo-5,8-Dihydroxy-1,4-Dihydronaphthalen)-2-Yl]-4-Methyl-3-Pentenyl Ester; 5,8-Dihydroxy-2-[(R)-1-Isovaleryloxy-4-Methyl-3-Pentenyl]-1,4-Naphthalenedione; Isovalerylshikonin; 5,8-Dihydroxy-2-(1-Isovaleryloxy-4-Methyl-3-Pentenyl)-1,4-Naphthalenedione; Alkannin Impurity 3; Butanoic Acid, 3-Methyl-, (1R)-1-(1,4-Dihydro-5,8-Dihydroxy-1,4-Dioxo-2-Naphthalenyl)-4-Methyl-3-Penten-1-Yl Ester; Isovalerylshikonin Usp/ep/bp
- CAS编号52387-14-1
- MFCD编号:MFCD00144522
- 分子式:C21H24O6分子量:372.42
- 产品CID: 2514694
- 产品分类生物化工 → 中草药成分
物理性质
MSDS等安全信息
上下游产品
shikonin isopentanoyl chloride 3-methylbutyric acid (S)-5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl)naphthalene-1,4-dione合成工艺路线路线简述
📜乙酰紫草素置于4-二甲氨基吡啶,Sodium Hydroxide,1-(3-二甲基氨基丙基)-3-乙基碳二亚胺体系中,用 甲醇,二氯甲烷 作为反应溶剂,化学反应生成 异戊酰紫草素
参考文献:Human Acat Inhibitory Effects Of Shikonin Derivatives From Lithospermum Erythrorhizon
标题:Human Acat Inhibitory Effects Of Shikonin Derivatives From Lithospermum Erythrorhizon
摘要:Three Naphthoquinones Were Isolated By Bioassay-Guided Fractionation From The Chcl3 Extracts Of Roots Of Lithospermum Erythrorhizon. They Were Identified As Acetylshikonin (1),Isobutyrylshikonin (2),And (3-Hydroxyisovalerylshikonin (3) On The Basis Of Their Spectroscopic Analyses. The Compounds 1-3 Were Tested For Their Inhibitory Activities Against Human Acat-1 (Hacat-1) Or Human Acat-2 (Hacat-2). Compound 2 Preferentially Inhibited Hacat-2 (Ic50 = 57.5 Wm) Than Hacat-1 (32% At 120 Mu M),Whereas Compounds 1 And 3 Showed Weak Inhibitory Activities In Both Hacat-1 And-2. To Develop More Potent Hacat Inhibitor,Shikonin Derivatives (5-11) Were Synthesized By Semi-Synthesis Of Shikonin (4),Which Was Prepared By Hydrolysis Of 1-3. Among Them,Compounds 5 And 7 Exhibited The Strong Inhibitory Activities Against Hacat-1 And-2. Furthermore,We Demonstrated That Compound 7 Behaved As A Potent Acat Inhibitor In Not Only In Vitro Assay System But Also Cell-Based Assay System. (C) 2006 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2006.11.024
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2905122000-异丙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:KR-102686376-B1
优先权日:2022-09-01
标 题 :Carbon quantum dots based on by-products of gromwell root and a method for synthesis of carbon quantum dots based on by-products of gromwell root
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1016/j.chroma.2020.461368
摘要:He JM, Huang J, Wu WL, Mu Q. Unlimited recycling counter-current chromatography for the preparative separation of natural products: Naphthaquinones as examples. J Chromatogr A. 2020 Aug 30;1626():461368. doi: 10.1016/j.chroma.2020.461368.
📝 需求与反馈
尽可能描述清楚需求与问题信息
