CAS: 40877-19-8; 4-Chloro-1-(4-Methoxyphenyl)Butan-1-One

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CAS号100-66-3 苯甲醚 | CAS号4635-59-0 4-氯丁酰氯 | CAS号33397-21-6 tris(4-methoxyp... | CAS号64214-66-0 4-氯-N-甲氧基-N-甲基丁酰胺 | CAS号13139-86-1 4-甲氧基苯基溴化镁 | CAS号104-92-7 对溴苯甲醚 | CAS号628-20-6 4-氯丁腈 | CAS号189079-75-2 4-azido-1-(4-me... | CAS号23002-61-1 Benzene,1-(4-ch... | CAS号7152-03-6 4-甲氧基苯基环丙基甲酮 | CAS号3309-01-1 2-(3-chloroprop... | CAS号22217-80-7 5-(4-甲氧基苯基)-3,4... | CAS号7347-70-8 2-[4-(4-methoxy... | CAS号56327-36-7 2-(3-chloroprop... | CAS号61025-28-3 1-(4-methoxyphe... | CAS号61025-29-4 1-(4-methoxyphe... | CAS号62170-25-6 1-(4-methoxyphe...

📜1-(4-氯丁基)-4-甲氧基苯置于六氟磷酸钾,Nickel(II) Triflate,水体系中,用 乙腈 作为反应溶剂,以67 %的收率获得产物γ-氯-4-甲氧基苯丁酮
参考文献:功能化烷基芳烃的选择性镍电催化苄基c-H氧化
标题:功能化烷基芳烃的选择性镍电催化苄基c-H氧化
摘要:在此,公开了由镍催化剂促进的官能化烷基芳烃的位点选择性配对电化学c-H氧化.原位形成的 Ni(II)-双氧物质能够在温和的条件下有效地实现氧化过程,底物范围广泛,具有优异的官能团兼容性,例如游离羧酸,醛,卤素(包括芳基碘),酰胺和氨基酸.镍催化剂与水的结合使用为氧化一系列复杂程度不同的分子和药物衍生物提供了一种安全,绿色和经济的方法,展示了其在有机合成和制药工业中的潜在应用.反应结果和机理研究揭示了原位ni(II)-双氧物种对于随后的 C(Sp 3)-h 键氧化的关键作用,并且短寿命的反应中间体(芳基自由基阳离子)被快速捕获双极超微电极 (Bume) 与纳米电喷雾电离质谱法的组合.
DOI:10.1016/j.Cclet.2023.108660

专利信息

专利号:US-2012302756-A1
优先权日:2010-02-19
标 题 :Process for synthesis of 2-substituted pyrrolidines and piperadines
发明人：LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
权利人:LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
摘要:The present invention provides a highly efficient, versatile one-step process for asymmetric synthesis of either diastereomer of 2-substituted pyrrolidines from a single starting material with excellent yields and high diastereoselectivety. Also provided is a method for the asymmetric synthesis of both diastereomers of 2-substituted piperidines with good yields and excellent diastereoselectivety. Diasteroselectivity is controlled effectively by choice of reducing agent.

专利号:US-9156840-B2
优先权日:2010-06-18
标题:D2 antagonists, methods of synthesis and methods of use
发明人：LUEHR GARY W; SUNDARAM ARATHI; JAISHANKAR PRIYADARSHINI; PAYNE PHILIP W; DRUZGALA PASCAL
权利人:ALTOS THERAPEUTICS LLC
摘要:Provided are D 2 or D 3 antagonist compounds and pharmaceutical compositions of formula I n nand pharmaceutically acceptable salts thereof, or isomers thereof, wherein R 1 , R 2 and R 3 are as defined herein. The invention further comprises methods for making the compounds of the invention and methods for the treatment of conditions mediated by the dopamine D 2 or D 3 receptor from the compounds of the invention.

专利号:WO-2011103263-A2
优先权日:2010-02-19
标题:Process for synthesis of 2-substituted pyrrolidines and piperadines

专利号:EP-2536687-A2
优先权日:2010-02-19
标 题 :Process for synthesis of 2-substituted pyrrolidines and piperadines

专利号:US-8691836-B2
优先权日:2010-06-18
标题 :D2 antagonists, methods of synthesis and methods of use

专利号:CA-2802188-A1
优先权日:2010-06-18
标题:D2 antagonists, methods of synthesis and methods of use