CAS: 368-90-1; (4-(Trifluoromethyl)Phenyl)Hydrazine

该化合物是一种有机化合物,其特征是附于一个三氟甲基替代物的苯环上的氢子体功能组;该化合物一般视温度和纯度而定,呈现为无色的黄色液体或固体;以其反应性而著称,特别是形成氮化合物和有机合成中的潜在中间体;该三氟甲基组可增强该化合物的亲脂性并影响其电子特性,使其在各种化学反应中发挥作用. 4-三氟甲基苯丙胺对于医药化学领域也具有兴趣,因为它可能展示生物活动;然而,由于该物质存在氢氮混合物,因此必须谨慎地处理该化合物,因为众所周知,氢氮具有毒性和潜在致癌性.在实验室环境中与该物质打交道时,应采取适当的安全防范措施.

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ECHA物质C&L通报REACH预注册

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CAS号98-56-6 4-氯三氟甲苯 | CAS号455-14-1 4-氨基三氟甲苯 | CAS号69732-95-2 N-(4-(trifluoro... | CAS号25102-84-5 p-trifluorobenz... | CAS号455-14-1 4-氨基三氟甲苯 | CAS号187998-54-5 5-氨基-1-[4-(氟甲基)... | CAS号2805-84-7 6-(三氟甲基)-2,3,4,... | CAS号320782-17-0 5-(三氟甲基)-1H-吲哚-3-乙胺 | CAS号201929-84-2 5-(三氟甲基)-1H-吲哚-... | CAS号78832-75-4 6-(trifluoromet... | CAS号398-36-7 4-三氟甲基联苯 | CAS号378802-40-5 2-(5-三氟甲基-1H-吲哚... | CAS号53451-87-9 N-phenyl-4-(tri...

合成工艺路线路线简述

    对三氟甲基苯胺置于盐酸,Sodium Nitrite,Sodium Chloride,Tin(Ll) Chloride体系中,用 水 作为反应溶剂,化学反应 2.0H,反应生成 4-(三氟甲基)苯肼
    参考文献:可见光介导的膦酰化反应:使用酞菁锌从烷基/芳基肼和亚磷酸三烷基酯形成膦酸盐
    标题:可见光介导的膦酰化反应:使用酞菁锌从烷基/芳基肼和亚磷酸三烷基酯形成膦酸盐
    摘要:在这项工作中,我们开发了一种无配体和无碱基的可见光介导方案,用于芳基膦酸盐的光氧化还原合成,并且首次用于烷基膦酸盐.锌酞菁光催化 C Sp 2-P 和 C Sp 3-P 键的形成是通过芳基/烷基肼与三烷基亚磷酸酯在空气作为丰富氧化剂的存在下反应有效实现的.反应条件容许多种官能团.
    DOI:10.1039/d1Ob00848J

    海关参考信息

    专利信息


    专利号:US-11040938-B2
    优先权日:2016-07-27
    标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
    发明人:MA BING; PAN SHUAI
    权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH
    摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

    专利号:US-7442802-B2
    优先权日:2002-06-27
    标 题:Cyclooxygenase-2 selective inhibitors, compositions and methods of use
    发明人:BANDARAGE UPUL K; EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; KHANAPURE SUBHASH P; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI
    权利人:NITROMED INC
    摘要:The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one COX-2 selective inhibitor, optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.

    专利号:US-2019152896-A1
    优先权日:2016-07-27
    标题 :Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts

    专利号:US-5393730-A
    优先权日:1993-01-12
    标题 :Nicotinic acid hydrazone compounds which have useful herbicidal compositions
    发明人:SMITH PHILIP HENRY GAUNT
    权利人:RHONE POULENC AGRICULTURE
    摘要:The invention relates to nicotinic acid hydrazone derivatives of formula I: ##STR1## in which the various symbols are as defined in the description, and their use as herbicides or as intermediates in the synthesis of herbicides.

    专利号:RU-2116304-C1
    优先权日:1992-04-28
    标题 :Derivatives of azole, method of their synthesis, pharmaceutical composition

    专利号:CN-117303991-A
    优先权日:2023-09-21
    标 题 :A kind of 4-trifluoromethyl substituted aromatic amine and its synthesis method
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    主要参考文献

    [参考文献]: Su-Hyeon Kim, Et Al. Fluorine-Functionalized And Simultaneously Reduced Graphene Oxide As A Novel Hole Transporting Layer For Highly Efficient And Stable Organic Photovoltaic Cells. Nanoscale. 2014 Jul 7;6(13):7183-7.

    合成参考文献


    摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 196.
    摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 110.
    摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 20.
    摘要:Harris, P. A., Science of Synthesis Knowledge Updates, (2021) 3, 183.
    摘要:Atodiresei, I.; Rueping, M., Science of Synthesis Knowledge Updates, (2017) 1, 382.
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