CAS: 272451-65-7; Flubendiamide

该化合物是一种合成杀虫剂,属于二酰胺,专门设计用于农业用途,主要作为选择性杀虫剂,针对包括毛虫在内的青蒿素虫害,通过调制甘蓝受体干扰其肌肉功能,干扰其肌肉功能,导致虫子瘫痪和最终死亡;氟丁二烯的特点是对非目标生物,包括有益昆虫,鸟类和哺乳动物的毒性较低,使其比传统杀虫剂更具环境友好性,通常用于各种配方,包括乳油和颗粒,有效控制蔬菜,水果和装饰品等作物中的虫害;该物质在正常储存条件下稳定,地下水污染潜力相对较低;但与所有农药一样,它应该用于标注指示,以尽量减少对人类健康和环境的风险;其效力和安全性简介使它成为综合虫害管理战略中的宝贵工具.

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CAS号272451-69-1 N2-[1,1-dimethy...

合成工艺路线路线简述

    📜3-Iodo-N1-(2-Methyl-4-Heptafluoroisopropylphenyl)-N2-(1,1-Dimethyl-2-Methylsulfonylethyl)-1,2-Benzene Formamide置于甲酸,硫酸,双氧水体系中,用 水,1,2-二氯乙烷 用作溶剂,化学反应 3.0H,反应生成3-碘-N'-(2-甲磺酰基-1,1-二甲基乙烷基-N-{4-[1,2,2,2-四氟-1-(三氟甲基)乙基]-0-甲苯基}邻苯二酰胺
    参考文献:Process For Producing 2-Halogenobenzamide Compound
    标题:Process For Producing 2-Halogenobenzamide Compound

    海关参考信息

    专利信息


    专利号:US-11680224-B2
    优先权日:2020-11-04
    标 题:Hydroxy fatty acid synthesis
    发明人:CERMAK STEVEN C; Isbell Terry; LOWERY BENJAMIN A
    权利人:US AGRICULTURE; THE US SECRATERY OF AGRICULTURE
    摘要:The invention relates to methods for the synthesis of hydroxy fatty acids from unsaturated fatty acids via epoxidation and catalytic hydrogenation.

    专利号:US-9068192-B2
    优先权日:2009-01-28
    标 题:Compositions and methods for conversion of aldehydes to alkanes
    发明人:ZENG WEIQING; HE SHENG YANG
    权利人:ZENG WEIQING; HE SHENG YANG; UNIV MICHIGAN STATE
    摘要:The invention provides the discovery that SCD2 (Susceptible to Coronatine-Deficient Pst DC3118-2) protein converts aldehydes to alkanes, thereby changing the composition and/or amount of synthesized waxes. The invention additionally provides homologs, orthologs and paralogs of SCD2 protein, and nucleotide sequences encoding these proteins. Also provided are expression vectors, transgenic cells, transgenic plants, transgenic seeds, methods for altering alkane production in cells, methods for identifying the function of a nucleotide sequence in the synthesis of plant surface wax, and methods for identifying plant tissue that has an altered surface wax composition. The invention's compositions and methods are useful for altering the amount and/or composition of wax produced by cells, including plants and seeds, that have been transformed with the invention's sequences.

    专利号:US-8729283-B2
    优先权日:2009-01-29
    标 题 :Chain-selective synthesis of fuel components and chemical feedstocks
    发明人:OLSON EDWIN S
    权利人:ENERGY & ENVIRON RES CT FOUND
    摘要:A method comprising providing a starting composition comprising a polyunsaturated fatty acid, a polyunsaturated fatty ester, a carboxylate salt of a polyunsaturated fatty acid, a polyunsaturated triglyceride, or a mixture thereof; self-metathesizing the starting composition or cross-metathesizing the starting composition with at least one short-chain olefin in the presence of a metathesis catalyst to form self-/cross-metathesis products comprising: cyclohexadiene; at least one olefin; and one or more acid-, ester-, or salt-functionalized alkene; and reacting cyclohexadiene to produce at least one cycloalkane or cycloalkane derivatives. A method for producing cycloalkanes for jet fuel by providing a starting composition comprising at least one selected from the group consisting of algal and polyunsaturated vegetable oils, subjecting the starting composition to metathesis to produce metathesis product comprising at least one olefin, cyclohexadiene, and at least one acid-, ester-, or salt-functionalized alkene, and reacting the at least one olefin and cyclohexadiene to form cycloalkane(s).

    专利号:WO-2025056767-A1
    优先权日:2023-09-15
    标题 :Process for the preparation of enantiomerically enriched aliphatic amines
    发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

    专利号:US-2016073631-A1
    优先权日:2013-03-04
    标 题 :Process for the preparation of dihydropyrrole derivatives
    发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
    权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
    摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

    专利号:US-9233920-B2
    优先权日:2010-06-11
    标题 :Process for the preparation of dihydropyrrole derivatives
    发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
    权利人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS; SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
    摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R 1 and R 2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R 1 and R 2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

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    主要参考文献

    1. Sun Q, Lin J, Peng Y, Gao R, Peng Y. Flubendiamide Enhances Adipogenesis and Inhibits AMPKα in 3T3-L1 Adipocytes. Molecules. 2018 Nov 12;23(11):2950. doi: 10.3390/molecules23112950. 2. Nareshkumar B, Akbar SM, Sharma HC, Jayalakshmi SK, Sreeramulu K. Evaluation of flubendiamide-induced mitochondrial dysfunction and metabolic changes in Helicoverpa armigera (Hubner). Arch Insect Biochem Physiol. 2017 Sep;96(1). doi: 10.1002/arch.21401. Epub 2017 Jun 20.

    合成参考文献


    摘要:US EPA; Pesticide Fact Sheet. Flubendiamide. Aug 2008. US EPA, Off Prevt Pest Tox Sub. (7505P). Available from, as of Feb 24, 2011:
    摘要:Purdue University; National Pesticide Information Retrieval System, Flubendiamide PC Code: 27602. Available from, as of January 25, 2011:
    摘要:Kato K et al; Biochemistry 48 (43): 10342-52 (2009)
    摘要:USEPA/Prevention, Pesticides, and Toxic Substances; Citizen's Guide to Pest Control and Pesticide Safety p.22 (March 2005) EPA 730-K-04-002
    摘要:Franke C et al; Chemosphere 29: 1501-14 (1994)
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