专利号:US-4515920-A 优先权日:1984-04-30 标题 :Synthesis of peptides and proteins 发明人:ERICKSON BRUCE W 权利人:UNIV ROCKEFELLER 摘要:Solid phase synthesis of peptides and proteins have been improved by the use of a trifunctional segment, one functional group of which is bound to a solid support, the other two functional groups being available as substrates upon which identical proteins are synthesized.
专利号:US-9650355-B2 优先权日:2013-01-31 标 题 :Method for preparation of justicidin a derivatives of arylnaphthalene lignan structure 发明人:HAM JUNGYEOB; KIM TAE JUNG; KWON HAK CHEOL; JEONG KYU HYUK; SONG JUNGHO; CHUNG BONG CHUL 权利人:KOREA INST SCI & TECH 摘要:The present disclosure relates to a novel method for preparing an arylnaphthalene lignan compound. In synthesis of arylnaphthalene lignan compounds and derivatives according to the present disclosure, a naphthalene backbone may be constructed first and an aryl group may be introduced at the final stage. Through this, various kinds of derivatives that could not be prepared from the existing methods can be synthesized effectively. Further, the synthesis method according to the present disclosure is appropriate for large-scale production.
专利号:EP-1567195-B1 优先权日:2002-11-26 标题 :Dendrimer conjugates for selective solubilisation of protein aggregates 发明人:HEEGAARD PETER; BOAS ULRIK 权利人:UPFRONT CHROMATOGRAPHY AS 摘要:Dendrimer conjugates are presented, which are formed between a dendrimer and a protein solubilising substance. Such dendrimer conjugates ar effective in the treatment of protein aggregate-related diseases (e.g. prion-related diseases). The protein solubilising substance and the dendrimer together show a protein aggregate solubilising effect higher than a physical mixture of the dendrimer and the protein solubilising substance (i.e. a synergistic effect). Such dendrimer conjugates are useful in the treatment or prevention of protein aggregate-relates diseases, in disinfection/decontamination processes and in classifying or identifying protein aggregates. The synthesis of such dendrimer conjugates from readily-available starting materials is described.
专利号:US-2010047841-A1 优先权日:2007-02-27 标 题 :Synthesis of desacetoxytubulysin h and analogs thereof 发明人:WIPF PETER; WANG ZHIYONG 权利人:UNIV PITTSBURGH 摘要:Compounds of formula I, XVI and XXI possess potent cell growth inhibitory activity. These compounds are described have therapeutic utility, particularly in the treatment of cancer as well as conditions and disorders related to uncontrolled cell growth: n n n n n n n n n n wherein the variables R 1 , R 2 , R 3 , R 4 , R 5 , X, Y and Z are described herein.
专利号:WO-2008106080-A2 优先权日:2007-02-27 标 题 :Synthesis of desacetoxytubulysin h and analogs thereof
专利号:CN-112521285-B 优先权日:2020-12-03 标题 :Synthesis process of di-tert-butyl dicarbonate