专利号:WO-2023203374-A1 优先权日:2022-04-20 标 题 :[1,2]selenazolo[2,3-a]pyridin-8-ium inhibitors of pyruvate kinase isoform m2 发明人:ARSENJANS PAVELS; DIMITRIJEVS PAVELS; MAKRECKA-KUKA MARINA 权利人:LATVIAN INST ORGANIC SYNTHESIS 摘要:The present invention relates to a novel isoselenazolopyridinium salts as anticancer agents by inhibiting pyruvate kinase isoform M2 (PKM2) activity, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment of various diseases and disorders by administration of such substances.
专利号:US-9987208-B2 优先权日:2013-04-04 标题 :Elastin synthesis/regeneration promoting agent 发明人:NISHIZAKI TOMOYUKI; TANAKA AKITO 权利人:NISHIZAKI BIOINFORMATION RES INSTITUTE 摘要:8-[2-(2-Pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) has an action to promote synthesis and regeneration of elastin, and is useful as an agent for the prophylaxis or improvement of wrinkles, and an anti-aging drug.
专利号:US-11517541-B2 优先权日:2017-04-20 标 题:Applications of spermidine and its derivatives 发明人:ZHU WEI; PAN WUGUANG 权利人:GENEHEAL BIOTECHNOLOGY CO LTD 摘要:Disclosed are applications of spermidine or its pharmaceutically acceptable derivatives. The inventors performed calculation and analysis using software based on existing data relating to protein and small-molecule structures, and screened out compounds which can effectively interfere with the activity of PAWS and thus reduce SAICAR synthesis, thereby achieving the goal of treating or improving tumors. It is expected to produce better effect in the treatment or improvement of tumors.
专利号:KR-102686376-B1 优先权日:2022-09-01 标 题 :Carbon quantum dots based on by-products of gromwell root and a method for synthesis of carbon quantum dots based on by-products of gromwell root
专利号:CN-101407783-A 优先权日:2008-11-26 标 题 :A method of using rare earth elements to promote the synthesis of shikonin in yunnanensis yunnanensis cells
专利号:CN-102851347-A 优先权日:2012-07-13 标题 :Novel use of hydrogen sulfide to promote the synthesis of secondary metabolites
参考文献:10.1007/s00894-011-1170-9 摘要:Jin R, Bai Y. Theoretical investigation of the radical scavenging activity of shikonin and acylshikonin derivatives. Journal of Molecular Modeling. 2011 Jul 15;18(4):1401–8. doi: 10.1007/s00894-011-1170-9. 参考文献:10.1155/2011/165852 摘要:Haghbeen K, Pourmolaei S, Mareftjo MJ, Mousavi A, Akbari Noghabi K, Hosseini Shirazi F, Meshkat A. Detailed Investigations on the Solid Cell Culture and Antimicrobial Activities of the Iranian Arnebia euchroma. BioMed Research International. 2011 Jan;2011(1). doi: 10.1155/2011/165852.