CAS: 22206-57-1; Tetrabutylammonium Fluoride Hydrate

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CAS号930-68-7 环己烯酮 | CAS号286-20-4 环氧环己烷 | CAS号822-67-3 2-环己烯-1-醇

专利信息

专利号:US-7358382-B2
优先权日:2001-08-03
标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production
发明人：WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:BAYER SCHERING PHARMA AG
摘要:The invention relates to 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production of these new intermediate products in the synthesis and the use for the production of epothilones or epothilone derivatives.

专利号:US-2025282813-A1
优先权日:2021-04-09
标 题 :Pseudo solid phase protecting group and methods for the synthesis of oligonucleotides and oligonucleotide conjugates
发明人：OKADA YOHEI; SUZUKI HIDEAKI; LUTHER ANATOL
权利人:BACHEM HOLDING AG
摘要:A novel pseudo solid phase protecting group and methods for the synthesis of oligonucleotides and oligonucleotide conjugates are provided. The pseudo solid phase protecting group is represented by formula II wherein: * indicates the point of attachment to an oxygen atom of a hydroxyl moiety of the nucleoside, the nucleotide, the oligonucleotide, or of the conjugate of a nucleoside, a nucleotide or an oligonucleotide to be protected; c is 0 or 1; a is an integer of 1 to 12; R3 is H; R5 is O—R6 or H, where R6 is a C8-C40 aliphatic hydrocarbon group; each of R4 is independently O—R6, where R6 is at each occurrence independently a C8-C40 aliphatic hydrocarbon group; b is 1 to 3; with the proviso that if b is 1, at least one of R3 and R5 is not H; and with the further proviso that the sum of all carbon atoms contained in the R3, R4, and R5 moieties present is larger than 23 and smaller than 200.

专利号:WO-2023000636-A1
优先权日:2021-07-20
标题:Method for synthesis of (3-fluorooxetan-3-yl)methyl 4-methylbenzenesulfonate
发明人：LIU YANG; WEI YUANBO; WANG QIUFENG; Xue Duoqing; WU YONG
权利人:ACCELA CHEMBIO CO LTD
摘要:A method for synthesis of (3-fluorooxetan-3-yl)methyl 4-methylbenzenesulfonate. A target product is prepared by using diethyl 2-fluoromalonate as a raw material and by means of a methylolation reaction, a hydroxyl protection reaction, a reduction reaction, an esterification reaction, a deprotection reaction, and a ring closure reaction in six steps. The steps are simple, the operation is easy, the raw material utilization rate and the product yield are high, intermediates are easy to separate, and the method is suitable for industrial scale-up production in terms of process safety, cost, raw material utilization rate, product purity, and the like. The results of embodiments show that the total yield of the reactions in the six steps of the method is 40-60%, and the HPLC purity of the target product (3-fluorooxetan-3-yl)methyl 4-methylbenzenesulfonate is greater than 97%.

专利号:US-11807600-B2
优先权日:2021-11-12
标题 :Synthesis of novel ketone body analogs for use as a nutritional supplement
发明人：ROZZONI SAMUEL J; SAUER DARYL R
权利人:ROZZONI SAMUEL J; SAUER DARYL R
摘要:When a healthy and balanced diet is not achieved, nutritional supplements are used to help deal with the resulting health issues and enhance the body's performance. The present invention relates to a novel category of molecules that combine the properties of both ketone bodies and β-Hydroxy β-Methylbutyrate (HMB) that can be used as supplements for treating a wide range of health-related issues. Acetoacetate and β-Hydroxybutrate along with isopentyldiol were used as the sources of ketone bodies and HMB, respectively. The present invention provides a method of synthesis for a new group of compounds that incorporate the properties found in acetoacetate and 3-hydroxybutyrate molecules with that of β-hydroxy β-methylbutyrate.

专利号:US-10047065-B2
优先权日:2014-12-17
标 题 :Formation of chromanes based on intermolecular reaction of alkynes with dimethylfuran in the presence of gold(I) complexes
发明人：LETINOIS ULLA; NETSCHER THOMAS
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a method of preparing chromanes from 2,5-dimethylfuran and substituted alkynes comprising an long chain unsaturated alkyl group as substituent in the alpha position of a substituted phenol followed by oxidation, reduction and acid ring closure. It is particularly advantageous to use 2,5-dimethylfuran as this offers an ecological beneficial synthesis of β-tocopherol.

专利号:US-6693091-B2
优先权日:2002-03-29
标 题 :Analogs of terpene trilactones from Ginkgo biloba for bioorganic and imaging studies
发明人：STROMGAARD KRISTIAN; SUEHIRO MAKIKO; NAKANISHI KOJI
权利人:UNIV COLUMBIA
摘要:A compound having the structure: n wherein R 1 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; n wherein R 2 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; n wherein R 3 is H or OH; n wherein R 4 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; and n wherein at least one of R 1 , R 2 , R 3 , or R 4 is a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety. Optically pure enantiomers and salts of the compound are also described. Also, the synthesis of the compound, and uses of the compound, such as in a method for detecting the localization of, or identifying, receptors, enzymes or other targets, whether in a cell or in a subject.