CAS: 192-97-2; Benzo[e]Pyrene

该化合物是一种多环芳烃(PAH),其特点是有引信的苯环,具体地说由五个芳香环组成;在室内温度下,它无色状黄色固态,以高度稳定性和疏水性而闻名,使其在水中不易溶解,但在有机溶剂中可溶解;苯丙烯主要是在矿物燃料和烟草等有机材料的不完全燃烧期间形成的,通常存在于环境污染物中;该化合物具有潜在的致癌性能,因为它可形成可能导致突变和癌症的DNA吸附剂,因此引起严重关切;其存在经常受到空气,土壤和食物产品的监测,因为其毒性影响.此外,苯并被用于研究致癌机制以及全氟辛烷对人类健康和环境的影响.鉴于其被归类为危险物质,适当的处理和处置对于减轻其风险至关重要.

结构式图片

相似化合物

135-48-8 191-07-1 191-24-2

欧盟法规

[统一分类与标签ECHA物质ECHA物质食品接触材料-禁用CMR物质化妆品禁用物质清单C&L通报工作场所安全标识要求REACH预注册废弃物危险特性清单

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合成工艺路线路线简述

  • 合成目标产物 Benzo[e]Pyrene 主要起始原料 Pyrene-4,5-Quinone
  • (文献来源)合成步骤主要原料 Pyrene-4,5-Quinone
📜(4S,5S)-4,5-Diethynyl-4,5-Dihydropyrene-4,5-Diol置于lithium Aluminium Tetrahydride,三氯氧磷体系中,用 吡啶,乙醚 用作溶剂,化学反应 18.17H,反应生成苯并[e]芘
参考文献:Novel Annelation Reaction: Synthesis Of Polycyclic Hydrocarbons From O-Quinones
标题:Novel Annelation Reaction: Synthesis Of Polycyclic Hydrocarbons From O-Quinones
摘要:
Doi:10.1021/jo00326A028

海关参考信息

专利信息


专利号:US-10711138-B2
优先权日:2016-04-08
标题:Intermediates and procedures for the synthesis of functional materials
发明人:KIRSCH PEER; GUNST SUSANN
权利人:MERCK PATENT GMBH
摘要:The present invention relates to heteroaromatic compounds which have two different reactive groups, their use in the synthesis of asymmetrically substituted compounds, and synthesis processes in which the compounds according to the invention are reacted sequentially with two different compounds, whereby an asymmetrically substituted compound is formed.

专利号:US-2003162992-A1
优先权日:2001-12-14
标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides
发明人:WATANABE KYOICHI A; DU JINFA
摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.

专利号:US-7645788-B2
优先权日:2001-06-06
标题 :Tetramerous derivative of indole-3-carbinol with anti-carcinogenic activity and method of synthesis of said derivative
发明人:MAGNANI MAURO; FIORUCCI CHIARA; FILIPPONE PAOLINO; BRANDI GIORGIO; PAIARDINI MIRKO
权利人:UNIV DEGLI STUDI URBINO
摘要:Use of the tetramerous derivative of indole-3-carbinol having formula I n nfor preparing a medicinal having anti-carcinogenic activity, and method of synthesis of the tetramerous derivative having formula I, in which indole-3-carbinol is reacted with an oxidizing agent so as to cause a polymeric oxidation of indole-3-carbinol.

专利号:US-12215369-B2
优先权日:2019-03-01
标题:Method for the in vivo synthesis of 4-hydroxymethylfurfural and derivatives thereof
发明人:ALEXANDRINO PAULO MOISES RADUAN; GOUVEA IURI ESTRADA; QUEIROZ VERONICA LEITE
权利人:BRASKEM SA
摘要:The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.

专利号:US-2025009786-A1
优先权日:2021-09-30
标 题 :Automated synthesis of polymeric dual drugs
发明人:MATRAY TRACY; VANBRUNT MICHAEL; MCCUTCHEON JOHN MICHAEL
权利人:SONY GROUP CORP
摘要:Compounds useful as biologically active compounds with or without fluorescent or colored dyes are disclosed. In some embodiments, the compounds have the following structure (I): (I) or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, L1, L2, L3, L4, L5, L6, L7, L8, L9, L10, L11, M1, M2, M3, l, m, n, p, and q are as defined herein. Additional compound, methods of preparation, pharmaceutical compositions, and methods of treatment related to compounds of Structure (I) are also provided.

专利号:US-11472779-B1
优先权日:2022-05-13
标 题 :One-pot synthesis of hydrogen-bonded organic frameworks
发明人:KHAN MOHD YUSUF; KHAN ABUZAR; HELAL AASIF; YAMANI ZAIN H
权利人:UNIV KING FAHD PET & MINERALS
摘要:A hydrogen-bonded organic framework (HOF) and a method of making the HOF. The HOF has at least one amine substituted organic linker and at least one carboxylic acid-based organic linker. The HOF is prepared by dissolving the linkers separately in water and mixing the aqueous solutions, without using any organic solvents, additional catalysts, or any other reagents.

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: Ana Lidia Apás, Et Al. Potential Of Goat Probiotic To Bind Mutagens. Anaerobe. 2014 Aug:28:8-12.
[参考文献]: Atif Kamal, Et Al. Exposure To Dust-Bound Pahs And Associated Carcinogenic Risk In Primitive And Traditional Cooking Practices In Pakistan. Environ Sci Pollut Res Int. 2015 Aug;22(16):12644-54.
[参考文献]: Atif Kamal, Et Al. Source, Profile, And Carcinogenic Risk Assessment For Cohorts Occupationally Exposed To Dust-Bound Pahs In Lahore And Rawalpindi Cities (Punjab Province, Pakistan). Environ Sci Pollut Res Int. 2015 Jul;22(14):10580-91.
[参考文献]: D W Rosenberg, Et Al. Regulation Of Cytochrome P450 In Cultured Human Colonic Cells. Arch Biochem Biophys. 1993 Jan;300(1):186-92.
[参考文献]: Hwanmi Lim, Et Al. Detection Of Benz[j]Aceanthrylene In Urban Air And Evaluation Of Its Genotoxic Potential. Environ Sci Technol. 2015 Mar 3;49(5):3101-9.

合成参考文献


摘要:Chang, C.-S.; Wu, Y.-T., Science of Synthesis, (2010) 45, 968.
摘要:Chang, C.-S.; Wu, Y.-T., Science of Synthesis, (2010) 45, 969.
摘要:T. Handa and M. Kobayashi. Yoki Gosei Kagaku Kyokai Shi 13, 580 (1955); 14, 337, 550 (1956); CA 51, 8439d.
摘要:Ko FC et al; Chemosphere 66: 277-285 (2007)
摘要:Groenewegen D, Stolp H; pp. 233-40 in Decomposition of Toxic and Nontoxic Organic Compounds in Soil. Overcash MR, ed., Ann Arbor, MI: Ann Arbor Publ (1981)
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