CAS: 17284-97-8; 3-Chloro-6-Hydrazinylpyridazine

相似化合物

5469-69-2 14959-32-1 64461-67-2

抑芽丹置于三氯氧磷,一水合肼体系中,化学反应生成3-氯-6-肼基哒嗪
参考文献:Synthesis Of New Derivatives Of Pyridazino[6,1-C]Pyrimido[5,4-E][1,2,4]Triazine; A Novel Heterocyclic System
标题:Synthesis Of New Derivatives Of Pyridazino[6,1-C]Pyrimido[5,4-E][1,2,4]Triazine; A Novel Heterocyclic System
摘要:通过在沸腾的乙醇中将 5-溴-2,4-二氯-6-甲基嘧啶与 3-氯-6-肼基哒嗪杂环化,然后用仲胺处理,合成了几种新型哒嗪并[6,1-C]嘧啶并[5,4-E][1,2,4]三嗪环系统的衍生物.
Doi:10.3184/174751916X14497690510968

专利信息

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:JP-S5934197-B2
优先权日:1972-08-30
标题 :Synthesis of antibacterial agent intermediates

专利号:CN-114540846-B
优先权日:2022-02-10
标题:Synthesis method of 1,2, 4-triazolo six-membered nitrogen heterocycle-3-amine