CAS: 15872-42-1; 4-(Heptyloxy)Benzoic Acid

该化合物是一种苯甲酸衍生物,其位置为七环氧替代物,该化合物主要用于合成液体晶状材料,因为它能够影响中相行为,其扩展的烷基链会提高有机溶剂的溶性,便于将其纳入聚合或小型分子系统,复合物具有稳定的热特性,适合于高级材料科学的应用,特别是在开发显示技术和光电子装置方面,其明确界定的分子结构可以进行精确的修改,为专门研究和工业应用提供定制的物理化学特性.

结构式图片

相似化合物

27893-41-0 2312-15-4 5519-23-3

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CAS号629-04-9 1-溴庚烷 | CAS号99-96-7 4-羟基苯甲酸 | CAS号27893-41-0 4-庚氧基苯甲醛 | CAS号67399-84-2 METHYL 4-HEPTYL... | CAS号154845-73-5 ethyl 4-heptoxy... | CAS号99-76-3 尼泊金甲酯 | CAS号120-47-8 尼泊金乙酯 | CAS号4282-40-0 1-碘庚烷 | CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛 | CAS号111-70-6 正庚醇 | CAS号55792-37-5 4-庚氧基苯异氰酸酯 | CAS号40782-54-5 4-庚氧基苯甲酰氯 | CAS号33905-65-6 (4-hydroxypheny... | CAS号61440-52-6 (4-heptoxypheny... | CAS号61440-54-8 ethyl 4-[(4-hep... | CAS号61440-55-9 4-[(4-heptoxyph...

合成工艺路线路线简述

    1-氯庚烷置于sodium Hydride体系中,化学反应 4.0H,反应生成4-正庚氧基苯甲酸
    参考文献:新的有效的白三烯c4和d4拮抗剂.1.合成与构效关系.
    标题:新的有效的白三烯c4和d4拮抗剂.1.合成与构效关系.
    摘要:(p-戊基肉桂酰基)邻氨基苯甲酸(3A)对ltd4-诱导的豚鼠回肠平滑肌收缩和ltc4诱导的豚鼠支气管收缩具有中等程度的拮抗活性.对3A的疏水部分(肉桂酰基部分)和亲水部分(邻氨基苯甲酸酯部分)进行了修饰.揭示了一系列的8-(苯甲酰基氨基)-2-四唑-5-基-1,4-苯并二恶烷和8-(苯甲酰基氨基)-2-四唑-5-基-4-氧代-4H-1-苯并吡喃.白三烯c4和d4的有效拮抗剂.在这两个系列中,Ono-Rs-347(18K)和ono-Rs-411(19H)分别是最有效和口服活性的拮抗剂.讨论了构效关系.
    Doi:10.1021/jm00396A013

    海关参考信息

    专利信息


    专利号:US-5098602-A
    优先权日:1988-05-11
    标题 :Novel halogen-containing ester compounds, and their intermediates, and method of producing the same as well as liquid crystal compositions containing the same and light switching elements
    发明人:HIRAI TOSHIHIRO; YOSHIZAWA ATSUSHI; NISHIYAMA ISA; FUKUMASA MITSUO; SHIRATORI NOBUYUKI; YOKOYAMA AKIHISA
    权利人:NIPPON MINING CO
    摘要:This invention provides a novel halogen-containing ester compound represented by the following general formula (I): ##STR1## (wherein R is an alkyl group, A is selected from a single bond, --O--, --COO-- and --CO--, both of X and Y are halogen atoms or either one of X and Y is a halogen atom and the other is a hydrogen atom, each of m and n is 0 or 1, m+n=0 or 1, each of k and l is an integer of 1 or more, provide k
    专利号:US-9217012-B2
    优先权日:2009-04-08
    标题 :Inhibitors of protein tyrosine phosphatases
    发明人:ZHANG ZHONG-YIN; ZHANG SHENG
    权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
    摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

    专利号:US-8816121-B2
    优先权日:2010-06-09
    标 题:GLP-1 receptor stabilizers and modulators
    发明人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; HUANG LIMING; TAMIYA JUNKO; GRIFFITH MARK T; FOWLER THOMAS; NOVAK ANDREW; KNAGGS MICHAEL; MEGHANI PREMJI
    权利人:RECEPTOS INC
    摘要:Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analysis of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided.

    专利号:US-9795613-B2
    优先权日:2014-12-10
    标题 :GLP-1 receptor modulators
    发明人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM R; BRAHMACHARY ENUGURTHI; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; KNAGGS MICHAEL; GLYNN DANIEL; MILLS MARK
    权利人:CELGENE INT II SÀRL
    摘要:Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ â€? represents either or both the R and S form of the compound): n nwhere A, B, C, Y 1 , Y 2 , Z, R 1 , R 2 , R 3 , R 4 , R 5 , W 1 , n, p and q are as defined herein.

    专利号:US-9700543-B2
    优先权日:2011-05-31
    标题 :GLP-1 receptor stabilizers and modulators
    发明人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; BRAHMACHARY ENUGURTHI; YEAGER ADAM RICHARD
    权利人:CELGENE INT II SÀRL
    摘要:Compounds that bind the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, methods of their therapeutic and/or prophylactic use, and methods of their use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor are provided. Certain compounds may have activity as modulators or potentiators with respect to glucagon receptor, GIP receptor, GLP-1 and GLP-2 receptors, and PTH receptor on their own or in the presence of receptor ligands such as GIP(1-42), PTH(1-34), Glucagon(1-29), GLP-2(1-33), GLP-1(7-36), GLP-1(9-36), oxyntomodulin and exendin variants.

    专利号:US-9187522-B2
    优先权日:2011-12-12
    标题 :GLP-1 receptor modulators
    发明人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM R; BRAHMACHARY ENUGURTHI; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; KNAGGS MICHAEL
    权利人:RECEPTOS INC
    摘要:The invention relates to compounds that modulate the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds are act as modulators or potentiators of GLP-1 receptor on their own, or with receptor ligands including GLP-1 peptides GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ â€? represents either or both the R and S form of the compound): n nwhere A, B, C, Y 1 , Y 2 , Z, R 1 , R 2 , R 3 , R 4 , R 5 , W 1 , n, p and q are as defined herein.
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    主要参考文献

    [参考文献]: Hyunshun Shin, Et Al. Amphipathic Benzoic Acid Derivatives: Synthesis And Binding In The Hydrophobic Tunnel Of The Zinc Deacetylase Lpxc. Bioorg Med Chem. 2007 Apr 1;15(7):2617-23.

    合成参考文献


    参考文献:10.1007/s13538-022-01239-9
    摘要:Balasubramanian V, Vijayakumar VN, Vasanthi T. Photonic Applications of Linear Double Hydrogen Bond Ferroelectric Liquid Crystal Mixture: Optical Modulators. Braz J Phys. 2023 Jan 03;53(2). doi: 10.1007/s13538-022-01239-9.
    参考文献:10.1007/s11182-024-03182-5
    摘要:Jayaprada P, Rao MC, Madhav BTP, Manepalli RKNR. Structure and Photoluminescence of p-(n-heptyloxy)benzoic Acid Liquid Crystals Dispersed With ZnO Nanoparticles. Russ Phys J. 2024 May 27;67(6):806–13. doi: 10.1007/s11182-024-03182-5.
    参考文献:10.1007/s10812-025-01990-2
    摘要:Trisanjya R, Mwakuna AE, Kumar CRS, Jayaprada P, Rao MC, Manepalli RKNR. Effect of Dysprosium-Doped Nanoparticles on Structural, Thermal, and Optical Properties of Liquid Crystalline p-(n-Heptyloxy) Benzoic Acid. J Appl Spectrosc. 2025 Sep;92(4):939–46. doi: 10.1007/s10812-025-01990-2.
    参考文献:10.1140/epjs/s11734-026-02176-3
    摘要:Kavitha S, Saravanakumar M, Kiranisha A, Vijayakumar VN, Chitravel T, Chakravarty S. Phase behaviours, spectroscopic, and DFT analysis of a complementary hydrogen bond liquid crystal complex with enhanced NLO properties. Eur. Phys. J. Spec. Top. 2026 Feb 24;(). doi: 10.1140/epjs/s11734-026-02176-3.
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