CAS: 15687-41-9; Oxyfedrine
- 英文名称Oxyfedrine
- 中文名称奥昔非君
- IUPAC名称1-Propanone, 3-((2-hydroxy-1-methyl-2-phenylethyl)amino)-1-(3-methoxyphenyl)-, (R-(R*,S*))-
- 其它别名(R-(R*,S*))-3-((2-Hydroxy-1-methyl-2-phenylethyl)amino)-1-( 3-methoxyphenyl)-1-propanone
- CAS编号15687-41-9
- FDA UNII编号:DWL616XF1K
- 分子式:C19H23NO3分子量:313.39
- 产品CID: 784210
- 产品分类原料药 → 循环系统用药 → 防治心绞痛药
物理性质
- 熔点107-109°C
- 沸点475.2 °C at 760 mmHg
- 闪点241.2 °C
- 密度1.122 g/cm3
- pKa:13.90±0.20(预测)
- PSA:58.56
- LogP:4.1726
- 折射率1.566
- 蒸汽压7.78E-10mmHg at 25°C
- 溶解性DMSO (Slightly), Methanol (Slightly), Toluene (Slightly)
- 外观形态白色至类白色固体
- 储存条件防潮, -20°C 冰箱, 在惰性气其中
- 产品应用奥昔非君(15687-41-9)的用途:治疗冠心病菌的药物,可增加冠脉血流量,增强心肌收缩力,改善冠状动脉循环,保证能量供应,改善心功能,特别适用于心绞痛及伴有心力衰竭的病人.主治各种心脏代谢不足,心肌循环不足和急性心肌梗塞,心绞痛的善后调理.
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2906210000-苄醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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专利信息
专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:US-2008107598-A1
优先权日:2006-10-05
标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications
专利号:AU-2007308022-B2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Oxyfedrine. Lancet. 1981 Jan 3;1(8210):25-6. 111(1):127-136. doi: 10.1111/cas.14224. Epub 2019 Nov 22.
3: Hahn N, Raqué B, Holst A, Henn I, von Randow H, Malotki D, Oehr P, Felix R. Die Wirkung von Oxyfedrin auf Hämodynamik, Inotropie und Durchblutung des partiell ischämiegeschädigten Myokards nach Prämedikation mit Digoxin. Untersuchungen am narkotisierten Hund [The action of oxyfedrine on haemodynamics, inotropism and blood perfusion of the partially ischaemic myocardium after digoxin premedication. Studies on anaesthetized dogs (author's transl)]. Arzneimittelforschung. 1981;31(3):410-4. German. 73(9):586-93. German. 51(1):5-13. doi: 10.1111/j.1476-5381.1974.tb09625.x.
6: Osswald W, Branco D. The lipolytic action of oxyfedrine in the dog. Pharmacology. 1971;5(3):145-52. doi: 10.1159/000136186. 8(3-4):161-6. doi: 10.1007/BF00567109. 21(1):81-8. doi: 10.1016/0014-2999(73)90210-0. 17(3):185-91. 47(4):827-37. doi: 10.1111/j.1476-5381.1973.tb08210.x.
合成参考文献
摘要:Pharmazie., 38(409), 1983 []
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