CAS: 150727-06-3; 4-Tert-Butyl-N-(6-Chloro-5-(2-Methoxyphenoxy)-2,2'-Bipyrimidin-4-yl)Benzenesulfonamide

上下游产品

CAS号6292-59-7 4-叔丁基苯磺酰胺 | CAS号150728-13-5 4,6-二氯-5-(2-甲氧基... | CAS号329923-17-3 5-(2-methoxyphe... | CAS号90-05-1 愈创木酚 | CAS号150726-89-9 2-(2-甲氧基苯氧基)丙二酸二甲酯 | CAS号14080-23-0 2-氰基嘧啶 | CAS号329923-15-1 4-hydroxy-5-(2-... | CAS号20730-58-9 (2-甲氧基苯氧基)丙二酸二乙酯

4,6-二羟基-5-(2-甲氧基苯氧基)-2-(2-嘧啶基)嘧啶置于caesium Carbonate,三氯氧磷体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 12.0H,反应生成N-[6-氯-5-(2-甲氧基苯氧基)[2,2'-二嘧啶]-4-基]-4-叔丁基苯磺酰胺
参考文献:内皮素受体拮抗剂波生坦的高效替代合成方法的开发
标题:内皮素受体拮抗剂波生坦的高效替代合成方法的开发
摘要:发表于<国际有机制备和程序:有机合成新期刊>(第 55 卷,第 5 期,2023 年)
Doi:10.1080/00304948.2023.2170665

专利信息

专利号:US-2012136015-A1
优先权日:2009-04-13
标题:Process for preparation of endothelial receptor antagonist (bosentan)
发明人：JOSHI SHREERANG; KHAN RASHID; BENDRE DEVEN; SALUNKHE DADASAHEB; GUDEKAR SANKET
权利人:JOSHI SHREERANG; KHAN RASHID; BENDRE DEVEN; SALUNKHE DADASAHEB; GUDEKAR SANKET; SANDOZ AG
摘要:The present invention relates to processes for the preparation of an endothelial receptor antagonist. The present invention particularly relates to synthesis of 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzene sulfonamide (bosentan).

专利号:US-8481730-B2
优先权日:2008-01-01
标 题 :Method of synthesis of Bosentan, its polymorphic forms and its salts
发明人：RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; PHULL MANJINDER SINGH; SAWANT ASHWINI AMOL
权利人:RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; PHULL MANJINDER SINGH; SAWANT ASHWINI AMOL; CIPLA LTD
摘要:The present invention relates to alkaline earth metal salts of bosentan, anyhdrous bosentan, polymorphic forms thereof, amorphous bosentan and processes for preparing them. The present invention further relates to a process for the preparation of bosentan and its pharmaceutically acceptable salts.

专利号:US-2010256371-A1
优先权日:2009-04-02
标题:Processes for the preparation of bosentan and its intermediates thereof
发明人：YADAV ROOP SINGH; KHAN MUBEEN AHMED; LAD SACHIN MAHADEO; TRIVEDI NIKHIL RASIKLAL; ARJUNAN SANKAR; PITALE GAJENDRA LAXMAN
权利人:GLENMARK
摘要:The present invention relates to processes for the preparation of bosentan and compounds that can be used as structurally novel intermediates for the synthesis thereof, and a pharmaceutical composition of the same.

专利号:WO-2009083739-A1
优先权日:2008-01-01
标 题:Method of synthesis of bosentan, its polymorphic forms and its salts

专利号:CA-2711043-A1
优先权日:2008-01-01
标题:Method of synthesis of bosentan, its polymorphic forms and its salts

专利号:US-2011015394-A1
优先权日:2008-01-01
标题 :Method of Synthesis of Bosentan, Its Polymorphic Forms and Its Salts