CAS: 14907-98-3; (1R,2S,3S,3As,3A1R,4R,6Ar,7Ar,11As,11Br)-Methyl 1,2,9-Trihydroxy-8,11A-Dimethyl-4-((3-Methylbut-2-Enoyl)Oxy)-5,10-Dioxo-2,3,3A,4,5,6A,7,7A,10,11,11A,11B-Dodecahydro-1H-3,3A1-(Epoxymethano)Dibenzo[de,G]Chromene-3-Carboxylate
该化合物是植物物种* Brassica oletraza* 的天然化合物,通称为卷心菜,属于以多种生物活动著称的菜类类,具有不同生物活动名目.布鲁萨托尔具有显著的特性,包括抗氧化剂和抗炎影响,因此对药理研究感兴趣.其结构具有氟化物骨干特征,有助于其与各种生物目标互动的能力.研究表明,布鲁萨托尔可以提高某些乳胶类制剂的功效,建议其在癌症治疗中的潜在应用.此外,还研究了其在调节细胞应激反应和促进细胞保护机制方面的作用.该化合物的溶性性和稳定性取决于配制和环境条件,而这些条件是其在医药化学中应用的重要因素.
- 英文名称(1R,2S,3S,3As,3A1R,4R,6Ar,7Ar,11As,11Br)-Methyl 1,2,9-Trihydroxy-8,11A-Dimethyl-4-((3-Methylbut-2-Enoyl)Oxy)-5,10-Dioxo-2,3,3A,4,5,6A,7,7A,10,11,11A,11B-Dodecahydro-1H-3,3A1-(Epoxymethano)Dibenzo[de,G]Chromene-3-Carboxylate
- 中文名称鸦胆子苦醇
- IUPAC名称methyl (1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-1,2,9-trihydroxy-8,11a-dimethyl-4-((3-methylbut-2-enoyl)oxy)-5,10-dioxo-1,4,5,6a,7,7a,10,11,11a,11b-decahydro-2H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-3(3aH)-carboxylate
- 其它别名13,20-Epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxopicras-3-en-21-oic acid methyl ester; 13,20-Epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxopicrasa-3-ene-21-oic acid methyl ester
- CAS编号14907-98-3
- MFCD编号:MFCD01746220
- FDA UNII编号:3ATY6SZ64B
- 分子式:C26H32O11分子量:520.53
- 产品CID: 717406
- 产品分类生物化工 → 提取物
物理性质
上下游产品
CAS号63306-30-9 Bruceoside A合成工艺路线路线简述
📜甲醇,Bruceoside D置于对甲苯磺酸体系中,化学反应 20.0H,以48.8%的收率获得鸦胆子苦醇
参考文献:Conversion Of Quassinoids For Enhancement Of Inhibitory Effect Against Epstein-Barr Virus Early Antigen Activation. Introduction Of Lipophilic Side Chain And Esterification Of Diosphenol.
标题:Conversion Of Quassinoids For Enhancement Of Inhibitory Effect Against Epstein-Barr Virus Early Antigen Activation. Introduction Of Lipophilic Side Chain And Esterification Of Diosphenol.
摘要:将酰基引入荆荭内酯b和c,并对苦苣醇和布鲁克因a中的二酚基团进行酯化,增强了对 Epstein-Barr 病毒早期抗原激活的抑制效果.
Doi:10.1248/cpb.48.876
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📌 第三方产品分析报告
主要参考文献
1: Zhang J, Fang X, Li Z, Chan HF, Lin Z, Wang Y, Chen M. Redox-sensitive micelles composed of disulfide-linked Pluronic-linoleic acid for enhanced anticancer efficiency of brusatol. Int J Nanomedicine. 2018 Feb 13;13:939-956. doi: 10.2147/IJN.S130696. eCollection 2018.
2: Zhang X, Wang Y, Velkov T, Tang S, Dai C. T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway. Food Chem Toxicol. 2018 Feb 9;114:88-97. doi: 10.1016/j.fct.2018.02.010. [Epub ahead of print] doi: 10.1038/s41598-018-19261-w.
4: Chen HM, Lai ZQ, Liao HJ, Xie JH, Xian YF, Chen YL, Ip SP, Lin ZX, Su ZR. Synergistic antitumor effect of brusatol combined with cisplatin on colorectal cancer cells. Int J Mol Med. 2018 Mar;41(3):1447-1454. doi: 10.3892/ijmm.2018.3372. Epub 2018 Jan 9.
合成参考文献
参考文献:10.5281/zenodo.5794106
摘要:The LOTUS Initiative for Open Natural Products Research: frozen dataset union wikidata (with metadata) | DOI:10.5281/zenodo.5794106
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