CAS: 144-24-1; 2-Amino-2,4-Dimethylpentanoic Acid

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312624-65-0 1231709-23-1 29589-03-5

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CAS号27886-67-5 5-甲基-5-(2-甲基丙基)... | CAS号60307-38-2 2-(benzylidenea... | CAS号71680-52-9 tetrabutylammon... | CAS号108-10-1 甲基异丁基甲酮

📜2-(Benzylideneamino)-2,4-Dimethylpentanenitrile置于盐酸体系中,化学反应生成Dl-Alfa-甲基亮氨酸
参考文献:Rai,M. Et Al.,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,1979,Vol. 18,P. 273-274
标题:Rai,M. Et Al.,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,1979,Vol. 18,P. 273-274

专利信息

专利号:WO-9517903-A1
优先权日:1993-12-28
标 题:Modular design and synthesis of oxazolone-derived molecules
发明人：HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG
权利人:ARQULE PARTNERS L P; HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG
摘要:The design and synthesis of novel oxazolone-derived molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs, and have applications in separations and materials science.

专利号:WO-2007034064-A1
优先权日:2005-09-21
标 题 :Continuous synthesis of an $g(a)-amino acid from a cyanhydrin of $g(a)-amino acid without the isolation of intermediate products
发明人：CASSE CLAUDE; GUIARD AGNES; MEDARD ALAIN
权利人:ADISSEO FRANCE SAS; CASSE CLAUDE; GUIARD AGNES; MEDARD ALAIN
摘要:The invention relates to a method for the continuous preparation of an a-amino acid having general formula (I) from the corresponding cyanhydrin of a-amino acid having general formula (II), in which R and R', which may be identical or different, optionally form a ring and each represent: H; an alkyl, haloalkyl or heteroaryl group containing between 1 and 30 carbon atoms, in a straight or branched chain; an alkenyl or alkynyl group containing between 2 and 30 carbon atoms, in a straight or branched chain; one or more cycloalkyl, cycloakenyl or cycloalkynyl groups containing between 3 and 30 carbon atoms, in a straight or branched chain; one or more aryl or heteroaryl groups containing between 1 and 10 carbon atoms per ring and optionally substituted by R; an alkaryl or aralkyl group containing between 5 and 30 carbon atoms, the terms aryl and alkyl having the definitions above; an alkoxy, alkoxyalkyl, alkylthioalkyl, alkylsulfonylalkyl, alkylaminoalkyl group containing between 1 and 30 carbon atoms, in a straight or branched chain; an alkoxyaryl group containing between 5 and 10 carbon atoms; one or more heterocyclic groups containing between 5 and 10 carbon atoms per ring; or a combination of one or more of the above groups, said groups being optionally substituted by R, by one or more nitro, cyano, hydroxy, carboxy, carbonyl or amino groups, by one or more halogens or by one or more nitrile, cyanhydrin, aldehyde functions. According to the invention: when R and R' together form a ring, said ring is as defined above; when R represents H, R' is different from H; and when R' represents H, R is different from H.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:WO-2025052429-A1
优先权日:2023-09-04
标 题 :An improved process for the preparation of tirzepatide
发明人：SIRIPRAGADA MAHENDER RAO; GANDAVADI SUNIL KUMAR; PARUMANCHALA SHAIK SHAVALI; TELAKALA HEMA SUNDARA RAO; SHAIK KALESHA
权利人:NEULAND LABORATORIES LTD
摘要:An improved process for the preparation of Tirzepatide having the chemical structural Formula I. The present invention also relates to the compounds of SEQ ID NO. 1 to 14 or a pharmaceutically acceptable salt thereof for use in the synthesis of Tirzepatide or a pharmaceutically acceptable salt thereof. The present invention further relates to the intermediate compounds of Formulae II to Formulae XVIII and its process of preparation, which are used in the preparation of Tirzepatide or a pharmaceutically acceptable salt thereof.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-11091522-B2
优先权日:2018-07-23
标题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.