CAS: 99365-40-9; 6-Bromoindolin-2-One

上下游产品

CAS号6127-11-3 2-硝基-4-溴苯乙酸 | CAS号6326-79-0 6-溴靛红 | CAS号7440-66-6 锌标准溶液 | CAS号199328-34-2 diethyl 2-(4-br... | CAS号100487-81-8 Propanedioic ac... | CAS号1355049-18-1 methyl {2-[(ani... | CAS号3460-18-2 2,5-二溴硝基苯 | CAS号552333-33-2 7-溴-1H-异色烯-1,3(... | CAS号1355049-15-8 5-bromo-2-(2-me... | CAS号1355049-16-9 methyl [2-(azid... | CAS号258831-98-0 6-(4-fluorophen... | CAS号893441-85-5 2-氧代吲哚啉-6-硼酸频哪醇酯 | CAS号63839-24-7 6-溴-2,3-二氢-1H-吲哚 | CAS号199327-63-4 2-氧代-2H-吲哚-6-甲腈 | CAS号1190866-02-4 6'-溴-1',2'-二氢螺[... | CAS号1190861-43-8 6-溴螺[1H-吲哚-3,4"... | CAS号1160247-29-9 6-溴-2-氧代-1,2-二氢... | CAS号158326-84-2 6-溴-3, 3-二甲基二氢吲哚-2-酮 | CAS号848649-94-5 6-BROMO-1,3-DIH... | CAS号90751-00-1 6-PHENYL-1,3-DI...

2,5-二溴硝基苯置于potassium Tert-Butylate,Lithium Chloride体系中,用 二甲基亚砜,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 6.17H,反应生成 6-溴-2-羟吲哚
参考文献:十字花科植物抗毒素brassilexin,Sinalexin,Wasalexins和类似物的简明合成:扩大vilsmeier甲酰化的范围
标题:十字花科植物抗毒素brassilexin,Sinalexin,Wasalexins和类似物的简明合成:扩大vilsmeier甲酰化的范围
摘要:通过将vilsmeier甲酰化应用到二氢吲哚-2-硫酮上,然后进行新的氨水后处理程序,证明了植物抗毒素黄铜素,芥辣素和类似物的有效合成.类似地,描述了使用顺式吲哚-2-酮的甲酰化-氨化非常精确的两锅合成植物抗毒素wasalexins.引人注目的是,这种新颖的氨水后处理允许顺序进行一锅甲酰化氨化反应,从而大大扩大了吲哚啉-2-硫酮和吲哚-2-酮的维尔斯迈尔甲酰化作用的范围.据报道,甲酰化-胺化反应的检查和条件的优化,以及几种黄铜蛋白类似物的合成和抗真菌活性.
DOI:10.1021/jo0479866

专利信息

专利号:US-8975418-B2
优先权日:2012-09-04
标 题 :Process for preparing 6-iodo-2-oxindole
发明人：SHI WENJIAN; SONG YANLI; BAO YUHUI; LU JUN; HUANG YAO; WEBER DIRK
权利人:SHI WENJIAN; SONG YANLI; BAO YUHUI; LU JUN; HUANG YAO; WEBER DIRK; BOEHRINGER INGELHEIM INT
摘要:Disclosed is a method for the synthesis of 6-iodo-2-oxindole useful as intermediate in the manufacture of pharmaceutically active ingredients. Also disclosed is a novel intermediate used in the synthesis of this compound.

专利号:WO-9948868-A9
优先权日:1998-03-26
标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase
发明人：FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:US-6514981-B1
优先权日:1998-04-02
标题:Methods of modulating tyrosine protein kinase function with indolinone compounds
发明人：TANG PENG CHO; SUN LI
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds. The invention also relates to methods of modulating the function of protein tyrosine kinases using indolinone compounds and methods of treating diseases by modulating the function of protein tyrosine kinases and related signal transduction pathways.

专利号:WO-0056709-A1
优先权日:1999-03-24
标 题:Indolinone compounds as kinase inhibitors
发明人：TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS G DAVIS; XIAOYUAN LI; LIANG CONGXIN
权利人:SUGEN INC; TANG PENG CHO; SUN LI; MCMAHON GERALD; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD; WEI CHUNG CHEN; HARRIS G DAVIS; XIAOYUAN LI; LIANG CONGXIN
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:US-8178559-B2
优先权日:2004-12-30
标 题:Organic compounds
发明人：BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI
权利人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI; NOVARTIS AG
摘要:3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.

专利号:US-6465507-B2
优先权日:2000-02-28
标题 :3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
发明人：TANG PENG CHO; MILLER TODD A; LI XIAOYUAN; ZHANG RUOFEI; CUI JINRONG; HUANG PING; WEI CHUNG CHUN
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.