CAS: 96525-23-4; Flurtamone

该化合物是一种该化合物是一种碳质生物合成抑制剂,具体针对阻断易感染杂草中叶绿素合成的酶素抗饱性抗药性.氟甲酮主要用于抗生素前和早期抗生素控制大叶素杂草以及谷物和豆类等作物中某些草种.其主要优势包括低应用率高效力,残留土壤活性以及有利的环境特征,包括对非目标生物的低毒性. 化合物对小麦和大麦等作物表现出强烈的选择性,使其成为综合杂草管理系统中的宝贵工具.

结构式图片

物理性质

欧盟法规

[欧盟农药活性物质

上下游产品

2-phenyl-3-oxo-4-(3-trifluoromethylphenyl)-5-amino-2,3-dihydrofuran N-benzyl-N,N,N-triethylammonium chloride dimethyl sulfate 3-trifluoromethylphenylacetonitrile

合成工艺路线路线简述

  • 2338-76-3 + 101-97-3 = 96525-23-4
    反应条件:1.1 Reagents: Sodium Methoxide Solvents: Methanol; Rt; 16 H,25 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 11.3 Reagents: Bromine Solvents: Methanol; Rt; 13 H,Rt1.4 Reagents: Benzyltriethylammonium Chloride,Sodium Hydroxide Solvents: Water; 3.5 H,Rt
    标题:Method For Producing Flurtamone
    参考文献:China]

    96525-22-3 = 96525-23-4 [标题:Reaction Conditions
    标题:Herbicidal 5-Amino-3-Oxo-4-(Substituted Phenyl)-2,3-Dihydrofurans,Their Derivatives,And Herbicidal Agents Containing Them.
    参考文献:Federal Republic Of Germany]

    = 96525-23-4 [标题:Reaction Conditions
    标题:Process Of Secondary And Tertiary Amines Of 3-Oxo-4-Substituted Phenyl-2,3-Dihydrofurans And -2,3-Dihydrothiophenes As Herbicides
    参考文献:United States
间三氟甲基苯乙腈置于溴,Sodium Methylate,十二烷基三甲基氯化铵,Sodium Sulfite体系中,用 甲醇,水,1,2-二氯乙烷 作为反应溶剂,化学反应 31.5H,反应生成 呋草酮
参考文献:高效除草剂呋草酮的生产方法
标题:高效除草剂呋草酮的生产方法
摘要:本发明公开了一种高效除草剂呋草酮的生产方法,以三氟甲基苯乙腈及苯乙酸乙酯为主要原料,经过克莱森缩合,在酸性溶剂下环化,甲基化三个步骤即可得到目标产物呋草酮.本发明具有安全性更高,反应纯化条件要求相对较低,分离相对容易,并且不易产生废酸排放,溶剂可回收套用,生产收率高等优点.本方法更能适用于呋草酮的工业化生产,更利于高效除草剂呋草酮的广泛应用.

海关参考信息

专利信息


专利号:WO-2024256370-A1
优先权日:2023-06-13
标 题 :Synthesis of glufosinate using an amidase-based process
发明人:ZIMMERMANN GUNTHER; POTT MORITZ STEFAN
权利人:BASF SE
摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.

专利号:US-2025120400-A1
优先权日:2021-12-10
标题:Synthesis of glufosinate using a hydantoinase-based process
发明人:DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN
权利人:BASF SE
摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.

专利号:US-11919928-B2
优先权日:2016-03-16
标题 :Method for producing dihydrotentoxin
发明人:KUBO TAKASHI; MACHIDA MASAYUKI; FUJIOKA TOMONORI; YAMAGUCHI Shigenari; KAWAI KIYOSHI
权利人:KUMIAI CHEMICAL INDUSTRY CO
摘要:An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.

专利号:US-2021386068-A1
优先权日:2018-11-07
标题 :Compositions comprising pyridine carboxylate herbicides and very long chain fatty acid (vlcfa) synthesis inhibitor herbicides
发明人:KISTER JEREMY; SATCHIVI NORBERT M
权利人:CORTEVA AGRISCIENCE LLC
摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a VLCFA synthesis inhibitor herbicide. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof, and (b) a VLCFA synthesis inhibitor herbicide.

专利号:US-2021352899-A1
优先权日:2018-11-07
标题 :Compositions comprising pyridine carboxylate herbicides and fatty acid and lipid synthesis inhibitor herbicides
发明人:KISTER JEREMY; SATCHIVI NORBERT M
权利人:CORTEVA AGRISCIENCE LLC
摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof.

专利号:ES-2717283-T3
优先权日:2012-07-24
标 题:Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6- (4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or a derivative thereof and herbicides inhibitors of VLCFA synthesis and synthesis of fatty acids / lipids
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主要参考文献


1: Zhang Y, Zhou L, Li R, Li Y, Tan Y, Shi H, Wang M. Comprehensive Assessment of Enantioselective Bioactivity, Toxicity, and Dissipation in Soil of the Chiral Herbicide Flurtamone. J Agric Food Chem. 2023 Mar 29;71(12):4810-4816. doi: 10.1021/acs.jafc.3c00223. Epub 2023 Mar 15. 77(12):5356-5366. doi: 10.1002/ps.6575. Epub 2021 Aug 6.
3: Hillebrands L, Lamshoeft M, Lagojda A, Stork A, Kayser O. Evaluation of Callus Cultures to Elucidate the Metabolism of Tebuconazole, Flurtamone, Fenhexamid, and Metalaxyl-M in Brassica napus L., Glycine max (L.) Merr., Zea mays L., and Triticum aestivum L. J Agric Food Chem. 2020 Nov 20. doi: 10.1021/acs.jafc.0c05277. Epub ahead of print. 94(2):476-8. doi: 10.1104/pp.94.2.476.
5: European Food Safety Authority (EFSA); Arena M, Auteri D, Barmaz S, Bellisai G, Brancato A, Brocca D, Bura L, Byers H, Chiusolo A, Court Marques D, Crivellente F, De Lentdecker C, De Maglie M, Egsmose M, Erdos Z, Fait G, Ferreira L, Goumenou M, Greco L, Ippolito A, Istace F, Jarrah S, Kardassi D, Leuschner R, Lythgo C, Magrans JO, Medina P, Miron I, Molnar T, Nougadere A, Padovani L, Parra Morte JM, Pedersen R, Reich H, Sacchi A, Santos M, Serafimova R, Sharp R, Stanek A, Streissl F, Sturma J, Szentes C, Tarazona J, Terron A, Theobald A, Vagenende B, Verani A, Villamar-Bouza L. Updated peer review of the pesticide risk assessment of the active substance flurtamone. EFSA J. 2017 Sep 8;15(9):e04976. doi: 10.2903/j.efsa.2017.4976.

合成参考文献


摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
摘要:S74 | REFTPS | Transformation Products and Reactions from Literature | DOI:10.5281/zenodo.4318838
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