CAS: 95715-85-8; Boc-D-Ser-Ome

• 英文名称Boc-D-Ser-Ome
• 中文名称Boc-D-丝氨酸甲酯
• IUPAC名称methyl (tert-butoxycarbonyl)-D-serinate
• 其它别名N叔丁氧羰基d丝氨酸甲酯; Tert-Butyl [(R)-1-(Methoxycarbonyl)-2-Hydroxyethyl]Carbamate
• CAS编号95715-85-8
• MFCD编号:MFCD00270516
• EINECS号:810-610-6
• FDA UNII编号:BB6YGX76JZ
• 分子式:C9H17NO5
• 分子量:219.24
• 产品CID: 2011488
• 产品分类有机原料→生命科学→氨基酸及其衍生物→丝氨酸及其衍生物

• 相似结构搜索
• InChIKey: SANNKFASHWONFD-ZCFIWIBFSA-N
• InChI=1S/C9H17NO5/c1-9(2,3)15-8(13)10-6(5-11)7(12)14-4/h6,11H,5H2,1-4H3,(H,10,13)/t6-/m1/s1…
• 计算化学: 氢键受体数5.0氢键供体数2可旋转键数3

相似化合物

物理性质

• 沸点354.3°C at 760 mmHg
• 闪点113°C
• 密度1.1±0.1 g/cm3
• pKa:10.70±0.46(预测)
• PSA:84.86
• LogP:0.045
• 折射率1.461
• 蒸汽压0.0±1.8 mmHg at 25°C
• 溶解性Chloroform, Methanol
• 敏感性避免接触强氧化剂
• 外观形态无色至黄色液体
• 储存条件置于阴暗处,密封, 常温干燥保存
• 产品应用该化合物用作实验室生物合成工艺.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
• 警示词Warning(警告)
• 危险描述H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
• UN编号NONH for all modes of transport
• 危险品标志Xi
• 安全声明26-36/37/39
• 危险类别码36/37/38
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 24424-99-5 + 24184-43-8 = 95715-85-8
  反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 3 H,0 °C -> 20 °C
  标题:A Novel Synthesis Of Highly Substituted Perhydropyrrolizines,Perhydroindolizines,And Pyrrolidines: Inhibition Of The Peptidyl-Prolyl Cis/trans Isomerase (Ppiase) Pin1
  作者:Siegrist,Romain; Zurcher,Martina; Baumgartner,Corinne; Seiler,Paul; Diederich,Francois; Et Al
  参考文献:Helvetica Chimica Acta 日期:2007 卷标:90(2) 页码:217-259]
  
  24424-99-5 + 24184-43-8 = 95715-85-8
  反应条件:1.1 Reagents: Triethylamine Solvents: Methanol; 14 H,Rt
  标题:Therapeutic Agent Or Prophylactic Agent For Pulmonary Hypertension Containing Nipecotic Acid Derivative
  参考文献:World Intellectual Property Organization]
  
  24424-99-5 + 24184-43-8 = 95715-85-8
  反应条件:1.1 Reagents: Triethylamine Solvents: Acetonitrile; 5 H,Rt
  标题:Hiv Inhibitor
  参考文献:China]
  
  24424-99-5 + 5874-57-7 = 95715-85-8
  反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 30 Min,Cooled1.2 Solvents: Dichloromethane; 30 Min,Cooled; 16 H,Rt
  标题:Methods And Intermediates For Synthesizing Sk1-I
  参考文献:United States]
  
  24424-99-5 + 5874-57-7 = 95715-85-8
  反应条件:1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran; 0 °C; 20 Min,140 °C
  标题:A Novel Agonist Of The Type 1 Lysophosphatidic Acid Receptor (Lpa1),Ucm-05194,Shows Efficacy In Neuropathic Pain Amelioration
  作者:Gonzalez-Gil,Ines; Zian,Debora; Vazquez-Villa,Henar; Hernandez-Torres,Gloria; Martinez,R. Fernando; Et Al
  参考文献:Journal Of Medicinal Chemistry 日期:2020 卷标:63(5) 页码:2372-2390]
  
  24424-99-5 + 24184-43-8 = 95715-85-8
  反应条件:1.1 Reagents: Triethylamine Solvents: Methanol; Cooled; 14 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; 1 H,Rt
  标题:Analgesic Containing Nipecotic Acid Derivative
  参考文献:World Intellectual Property Organization]
  
  24424-99-5 + 24184-43-8 = 95715-85-8
  反应条件:1.1 Reagents: Triethylamine Solvents: Methanol; Cooled; 14 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; 1 H,Rt
  标题:Preparation Of Nipecotic Acid Derivatives As Seh Inhibitors
  参考文献:World Intellectual Property Organization]
  
  24424-99-5 + 5874-57-7 = 95715-85-8
  反应条件:1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran; Rt -> 0 °C1.2 Solvents: Tetrahydrofuran; < 1 H,0 °C; 14 H,Rt; 3 H,50 °C
  标题:Synthesis Of D-Abrines By Palladium-Catalyzed Reaction Of Ortho-Iodoanilines With N-Boc-N-Methylalanyl-Substituted Acetaldehyde And Acetylene
  作者:Danner,Paulami; Morkunas,Marius; Maier,Martin E.
  参考文献:Organic Letters 日期:2013 卷标:15(10) 页码:2474-2477]
  
  24424-99-5 + 5874-57-7 = 95715-85-8
  反应条件:1.1 Reagents: Diisopropylethylamine Solvents: Dichloromethane; Rt; Overnight,Rt
  标题:Piperidine Derivatives As Aspartic Protease Inhibitors And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Aspartic Protease Mediated Diseases
  参考文献:World Intellectual Property Organization]
  
  24424-99-5 + 5874-57-7 = 95715-85-8
  反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: Tetrahydrofuran,Water; 12 H,Rt
  标题:Novel Peptidomimetic Cysteine Protease Inhibitors As Potential Antimalarial Agents
  作者:Micale,Nicola; Kozikowski,Alan P.; Ettari,Roberta; Grasso,Silvana; Zappala,Maria; Et Al
  参考文献:Journal Of Medicinal Chemistry 日期:2006 卷标:49(11) 页码:3064-3067

海关参考信息

• 2905122000-异丙醇
  2905143000-叔丁醇
  2905399001-1,3-丙二醇
  2912110000-甲醛
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管