CAS: 93479-97-1; 3-Ethyl-4-Methyl-N-(4-(N-((Rel-(1R,4R)-4-Methylcyclohexyl)Carbamoyl)Sulfamoyl)Phenethyl)-2-Oxo-2,5-Dihydro-1H-Pyrrole-1-Carboxamide

• 英文名称3-Ethyl-4-Methyl-N-(4-(N-((Rel-(1R,4R)-4-Methylcyclohexyl)Carbamoyl)Sulfamoyl)Phenethyl)-2-Oxo-2,5-Dihydro-1H-Pyrrole-1-Carboxamide
• 中文名称格列美脲
• IUPAC名称3-ethyl-4-methyl-N-(4-(N-(((1r,4r)-4-methylcyclohexyl)carbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
• 其它别名Glimepiride [usp-Rs]; 24T6Xir2Mz; Glimepiride (Jp17/usp/inn); Glista Od; Glimepiride [usp Monograph]; Glimepiride Impurity A; Glimepiride- Bio-X; Glymepiri
• CAS编号93479-97-1
• MFCD编号:MFCD00878417
• EINECS号:642-919-5
• 分子式:C24H34N4O5S
• 分子量:490.63
• 产品CID: 1974420
• 同类组份化合物CAS119018-29-0 (sulfonamide)119018-30-3 (urethane)93479-97-1
• 产品分类原料药 → 激素及调节内分泌功能类药 → 胰腺激素及其它调节血糖药

• 相似结构搜索
• 产品信息参考;
• InChIKey: WIGIZIANZCJQQY-RUCARUNLNA-N
• InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19…
• 计算化学: 氢键受体数5.0氢键供体数3.0可旋转键数7.0

物理性质

• 熔点212.2-214.5  °C
• 沸点677.0±65.0 °C at 760 mmHg
• 闪点363.2±34.3 °C
• 密度1.3±0.1 g/cm3
• pKa:5.10±0.10(预测)
• PSA:133.06
• LogP:4.17
• 折射率1.628
• 蒸汽压0.0±2.2 mmHg at 25°C
• 溶解性DMSO: >10 mg/mL
• 敏感性常温常压下稳定，避免与强氧化剂接触。
• 外观形态白色固体
• 储存条件室温
• 产品应用降血糖药.
• 性质描述格列美脲(93479-97-1)的化学性质:熔点207°C.

MSDS等安全信息

• GHS象形图
• GHS符号GHS08;
  注释: Health hazard
• 危险类别生殖毒性 类别2
  急性毒性 类别3(吸入)
  急性毒性 类别3(经口)
  严重眼刺激 类别2
• 警示词Warning(警告)
• 危险描述H361 |怀疑对生育能力或胎儿造成损害.
  H331 |吸入会中毒.
  H301 |吞咽会中毒.
  H319 |造成严重眼刺激.
• 防范说明P201-P202-P280-P308+P313-P405-P501
• UN编号NONH for all modes of transport
• 危险品标志Xn,Xi
• 安全声明25-26-36/37-53
• 危险类别码21-36/38-46-62-63
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 Glimepiride 主要起始原料 3-Ethyl-4-Methyl-3-Pyrrolin-2-One
• 119018-29-0 = 93479-97-1
  反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 7 H,Rt
  标题:Preparation Method Of Glimepiride For Anti-Diabetes Drug
  参考文献:China]
  
  32175-00-1 + 119018-29-0 = 93479-97-1
  反应条件:1.1 Reagents: Potassium Carbonate Solvents: Tetrahydrofuran; 1 - 2 H,Rt -> 65 °C1.2 Solvents: Toluene; 10 - 12 H,60 - 65 °C; Cooled1.3 Reagents: Ammonia Solvents: Methanol; Ph 10 - 121.4 Reagents: Acetic Acid; Ph 5.5 - 6.0,25 - 30 °C
  标题:A Process For Purification Of Glimepiride
  参考文献:India]
  
  119018-29-0 + 321655-42-9 = 93479-97-1
  反应条件:1.1 Reagents: Sodium Methoxide Solvents: Dimethyl Sulfoxide1.2 Reagents: Water
  标题:Improved Process For The Preparation Of Benzenesulfonylureas Used As Second-Generation Oral Hypoglycemic Agents
  参考文献:World Intellectual Property Organization]
  
  318515-70-7 + 2523-55-9 = 93479-97-1
  反应条件:1.1 Solvents: Toluene
  标题:Studies On Synthetic Process Of Glimepiride,New Hypoglycemic Agent
  作者:Deng,Yong; Zhong,Yuguo; Tang,Weigao; Zhong,Zhicheng
  参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2000 卷标:10(2) 页码:134-137]
  
  75-98-9 + 318515-70-7 + 2523-55-9 = 93479-97-1
  反应条件:1.1 Solvents: Toluene; Rt1.2 Rt -> Reflux; 4 H,Reflux; Reflux -> 15 °C
  标题:Process For Preparing Glimepiride And Corresponding Intermediate
  参考文献:Czech Republic]
  
  32175-00-1 + 119018-29-0 = 93479-97-1
  反应条件:1.1 Reagents: Triethylamine,Ethyl Chloroformate Solvents: Dichloromethane; 2 H,20 - 25 °C1.2 Reagents: Acetic Acid Solvents: Water; Ph 4 - 4.2; 30 Min1.3 Reagents: 4-(Dimethylamino)Pyridine Solvents: Toluene; Rt -> Reflux; 3 H,Reflux; Reflux -> 30 °C; 3 H,25 - 30 °C
  标题:An Improved Process For The Preparation Of N-{2-[4-(Aminosulfonyl)Phenyl]Ethyl}-3-Ethyl-4-Methyl-2-Oxo-2,5-Dihydro-1H-Pyrrole-1-Carboxamide,A Key Intermediate In The Synthesis Of Glimepiride
  参考文献:India]
  
  119018-29-0 + 530-62-1 + 2523-55-9 = 93479-97-1
  反应条件:1.1 Reagents: Diisopropylethylamine Solvents: Dimethylformamide; 3 H,Rt -> 25 °C1.2 Solvents: Dimethylformamide; Overnight,Heated
  标题:Preparation Method Of Glimepiride
  参考文献:China]
  
  32175-00-1 + 119018-29-0 = 93479-97-1
  反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetonitrile; Rt -> 60 °C1.2 6 H,50 - 60 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 1 - 2,20 - 25 °C
  标题:Synthetic Preparation Of Glimepiride Bulk Drug
  参考文献:China]
  
  32175-00-1 + 119018-29-0 = 93479-97-1
  反应条件:1.1 Solvents: Tert-Butyl Methyl Ether1.2 Solvents: Toluene,Cyclohexanone,Tert-Butyl Methyl Ether; 10 H,30 °C
  标题:Method For Preparing Hypoglycemic Drug Glimepiride
  参考文献:China]
  
  318515-70-7 + 2523-55-9 = 93479-97-1
  反应条件:1.1 Reagents: 4-(Dimethylamino)Pyridine Solvents: Toluene; Rt -> Reflux
  标题:Method For The Manufacture Of Compounds Related To The Class Of Substituted Sulfonyl Urea Antidiabetics
  参考文献:European Patent Organization]
  
  32175-00-1 + 119018-29-0 = 93479-97-1
  反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone,Methyl Ethyl Ketone; 30 Min,Rt -> Reflux1.2 5 - 6 H,Reflux1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 6
  标题:Preparation Of Glimepiride
  参考文献:China]
  
  32175-00-1 + 119018-29-0 = 93479-97-1
  反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; 1 H,55 - 60 °C1.2 Solvents: Toluene; 12 H,Reflux1.3 Reagents: Acetic Acid Solvents: Water; Ph 5.5 - 6,20 - 25 °C
  标题:A Novel Process For Preparation Of Substantially Pure Glimepiride
  参考文献:World Intellectual Property Organization]
  
  119018-29-0 + 1988102-95-9 = 93479-97-1
  反应条件:1.1 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene Solvents: Acetonitrile; 5 H,Reflux
  标题:An Efficient And Practical Process For The Synthesis Of Glimepiride
  作者:Tanwar,Dinesh Kumar; Surendrabhai,Vaghela Ravikumar; Gill,Manjinder Singh
  参考文献:Synlett 日期:2017 卷标:28(18) 页码:2495-2498]
  
  32175-00-1 + 119018-29-0 = 93479-97-1
  反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; 6 H,Reflux1.2 6 H,Reflux; Reflux -> Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
  标题:Studies On The Preparation Of Glimepiride
  作者:Liu,Sheng-Gao
  参考文献:Shandong Huagong 日期:2009 卷标:38(6) 页码:14-15]
  
  32175-00-1 + 119018-29-0 = 93479-97-1
  反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; 6 H,Reflux1.2 8 H,Reflux; Reflux -> Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 1 - 2
  标题:Synthesis Of 3-Ethyl-2,5-Dihydro-4-Methyl-N-[2-[4-[[[[(Trans-4-Methylcyclohexyl)Amino]Carbonyl]Amino]Sulfonyl]Phenyl]Ethyl]-2-Oxo-1H-Pyrrole-1-Carboxamide (Glimepiride)
  作者:Liu,Zhanke; Yang,Xinwu; Lu,Qihui; Wang,Xiaoguang; Liu,Zhiling
  参考文献:Jingxi Huagong Zhongjianti 日期:2006 卷标:36(3) 页码:16-18]
  
  93479-97-1 = 93479-97-1
  反应条件:1.1 Reagents: Sodium Hydroxide,Zinc Chloride Solvents: Dimethylformamide,Water; Ph 6.5 - 8,Rt; 3 H,80 °C
  标题:Synthesis,Physico-Chemical And Antidiabetic Studies Of Zinc Complex Of Glimepiride,An Oral Hypoglycemic Agent
  作者:Jacob,George
  参考文献:Oriental Journal Of Chemistry 日期:2013 卷标:29(4) 页码:1351-1358

海关参考信息

• 2901210000-乙烯
  2901220000-丙烯
  2902600000-乙苯
  2912110000-甲醛
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管