CAS: 877399-50-3; Tert-Butyl 4-(4-Bromo-1H-Pyrazol-1-yl)Piperidine-1-Carboxylate

相似化合物

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CAS号2075-45-8 4-溴吡唑 | CAS号141699-59-4 1-B°C-4-甲烷磺酰氧基哌啶 | CAS号109384-19-2 N-B°C-4-羟基哌啶 | CAS号5382-16-1 4-羟基哌啶 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号877399-74-1 4-[4-(4,4,5,5-四...

4-羟基哌啶置于sodium Hydride,三乙胺体系中,用 二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 16.0H,反应生成 4-(4-溴吡唑-1-基)哌啶-1-甲酸叔丁酯
参考文献:Protein Kinase Inhibitors
标题:Protein Kinase Inhibitors
摘要:公式(i)的化合物中,其中r3,R4,G,B,M和z如权利要求中所定义,并且其药学上可接受的盐已被披露.公式(i)的化合物具有作为fgfr抑制剂的效用,并且在需要fgfr激酶抑制的情况下,如癌症治疗中是有用的.

专利信息

专利号:CN-118324790-A
优先权日:2024-04-16
标 题 :A method for photocatalytic synthesis of crizotinib intermediates

专利号:US-8785632-B2
优先权日:2004-08-26
标 题:Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
发明人：CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE
权利人:CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE; AGOURON PHARMA; PFIZER
摘要:Enantiomerically pure compound of formula 1 n nare provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

专利号:EP-1784396-B8
优先权日:2004-08-26
标 题 :Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors
发明人：CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE BICH
权利人:PFIZER
摘要:Compounds of formula (1) are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

专利号:US-9604966-B2
优先权日:2013-02-16
标 题 :Crizotinib preparation method
发明人：LI YUANQIANG; QIAN JIANQIANG; CHE DAQING
权利人:ZHEJIANG JIUZHOU PHARM CO LTD; ZHEJIANG JIUZHOU PHARM CO LTD
摘要:The present invention relates to the technical field of medicine and organic synthesis, particularly to a method for preparing crizotinib. The method comprises the compound of formula b and the compound of formula e undergoing Suzuki coupling reaction to produce the compound of formula a which then was subjected to deprotection to afford (±) crizotinib.