CAS: 73032-94-7; 22-((1H-Indol-3-yl)Methyl)-37-(2-(2-(6-Amino-2-(2-(4-Carboxy-2-(5-Guanidino-2-(1-(Serylalanylasparaginylserylasparaginylprolylalanylmethionylalanyl)Pyrrolidine-2-Carboxamido)Pentanamido)Butanamido)-5-Guanidinopentanamido)Hexanamido)Propanamido)Acetamido)-31-(2-Amino-2-Oxoethyl)-19,34-Bis(4-Aminobutyl)-13,25,28-Tribenzyl-10,16-Bis(1-Hydroxyethyl)-7-(Hydroxymethyl)-6,9,12,15,18,21,24,27,30,33,36-Undecaoxo-1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35-Undecaazacyclooctatriacontane-4-Carboxylic Acid

该化合物是一种浸泡激素,在调控各种生理过程,包括抑制生长激素释放和调节胰岛素和凝胶分泌方面发挥着关键作用;它是由若干异形组成的索马托斯塔廷家族的成员,该家族由若干个异形组成,其中索马托斯塔丁 28 是源自前蛋白质前体的较长形式之一; peptide由28种氨酸组成,呈现出一种循环结构,有助于其稳定性和生物活动; Somatostatin 28主要产于低丘和胃肠道,在其中对特定受体采取行动以施加其影响; 其功能延伸至中央...

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    专利信息


    专利号:US-11033507-B2
    优先权日:2013-12-19
    标 题 :Method of synthesis of silica vesicles and use thereof
    发明人:YU CHENGZHONG; MITTER NEENA; ZHANG JUN
    权利人:UNIV QUEENSLAND
    摘要:The invention relates, in part, to a method of producing silica vesicles including under controlled conditions to thereby heavily influence the morphology and characteristics of the vesicles. The vesicles are shown to be effective as delivery agents for chemical and biological agents. They are also shown to be useful in methods of treatment and as components of an immunogenic composition.

    专利号:US-2018193278-A1
    优先权日:2013-12-19
    标题 :Method of synthesis of silica vesicles and use thereof

    专利号:US-4202802-A
    优先权日:1978-10-02
    标 题 :Peptides related to somatostatin
    发明人:SHIELDS JAMES E
    权利人:LILLY CO ELI
    摘要:The tetradecapeptides of the formula wherein X is H-Ala-D-Ala, H-D-Ala-Gly, or H-D-Val-Gly; and X is Ala-Leu, Ala-Phe, Ala-D-Phe, D-Ala-Phe, or D-Ala-Cha; or the non-toxic, pharmaceutically acceptable acid addition salts thereof; inhibit secretion of growth hormone, while not materially inhibiting the secretion of insulin or glucagon. Intermediates used in the synthesis of the tetradecapeptides are also described.

    专利号:CA-2933910-A1
    优先权日:2013-12-19
    标 题 :Method of synthesis of silica vesicles and use thereof

    专利号:AU-2014366842-B2
    优先权日:2013-12-19
    标 题:Method of synthesis of silica vesicles and use thereof

    专利号:US-11407837-B2
    优先权日:2017-09-11
    标 题 :GPCR binding proteins and synthesis thereof
    发明人:GLANVILLE JACOB
    权利人:TWIST BIOSCIENCE CORP
    摘要:Provided herein are methods and compositions relating to G protein-coupled receptor (GPCR) libraries having nucleic acids encoding for a scaffold comprising a GPCR binding domain. Libraries described herein include variegated libraries comprising nucleic acids each encoding for a predetermined variant of at least one predetermined reference nucleic acid sequence. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

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    合成参考文献


    参考文献:10.1073/pnas.1803146115
    摘要:Jian X, Felsenfeld G. Insulin promoter in human pancreatic β cells contacts diabetes susceptibility loci and regulates genes affecting insulin metabolism. Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4633–41.
    参考文献:10.1159/000139452
    摘要:Milosević V, Velkovski S, Brkić B, Sekulić M, Lovren M, Starcević V, Severs WB. Inhibitory effects of centrally administered somatostatin on the adrenal zona glomerulosa in male rats. Pharmacology. 1996 Dec;53(6):369–75. doi: 10.1159/000139452.
    参考文献:10.1152/ajpendo.00434.2001
    摘要:Chisholm C, Greenberg GR. Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures. American Journal of Physiology-Endocrinology and Metabolism. 2002 Aug 01;283(2):E311–7. doi: 10.1152/ajpendo.00434.2001.
    参考文献:10.1016/s0003-2697(02)00007-6
    摘要:Birzin ET, Rohrer SP. High-throughput receptor-binding methods for somatostatin receptor 2. Anal Biochem. 2002 Aug 01;307(1):159–66. doi: 10.1016/s0003-2697(02)00007-6.
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