CAS: 67853-37-6; 2-Bromo-1-Methoxy-3-Nitrobenzene

上下游产品

2-bromo-3-hydroxy-1-nitrobenzene dimethyl sulfate 2-methoxy-6-nitroaniline 2-Amino-3-nitrophenol 2-bromo-3-methoxyaniline indole4-methoxy-1-(4-methylphenyl)sulfonylindole 2-bromo-3-methoxy-N-tosylaniline 2-ethenyl-3-methoxy-N-(p-tolylsulfonyl)aniline

2-氨基-3-硝基苯酚置于氢溴酸 硫酸,Potassium Carbonate,Copper(I) Bromide,Sodium Nitrite体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 2-溴-3-硝基苯甲醚
参考文献:7'-Substituted Benzothiazolothio-And Pyridinothiazolothio-Purines As Potent Heat Shock Protein 90 Inhibitors
标题:7'-Substituted Benzothiazolothio-And Pyridinothiazolothio-Purines As Potent Heat Shock Protein 90 Inhibitors
摘要:We Report On The Discovery Of Benzo-And Pyridino-Thiazolothiopurines As Potent Heat Shock Protein 90 Inhibitors. The Benzothiazole Moiety Is Exceptionally Sensitive To Substitutions On The Aromatic Ring With A 7'-Substituent Essential For Activity. Some Of These Compounds Exhibit Low Nanomolar Inhibition Activity In A Her-2 Degradation Assay (28-150 Nm),Good Aqueous Solubility,And Oral Bioavailability Profiles In Mice. In Vivo Efficacy Experiments Demonstrate That Compounds Of This Class Inhibit Tumor Growth In An N87 Human Colon Cancer Xenograft Model Via Oral Administration As Shown With Compound 37 (8-(7-Chlorobenzothiazol-2-Ylsulfanyl)-9-(2-Cyclopropylamino-Ethyl)-9H-Purin-6-Ylamine).
DOI:10.1021/jm051146H

专利信息

专利号:US-9067934-B2
优先权日:2011-03-31
标题 :Bicyclic pyridinones
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; FISH BENJAMIN ADAM; GREEN MICHAEL ERIC; MULLINS PATRICK BRADLEY; STIFF CORY MICHAEL; TRAN TUAN PHONG; NAVARATNAM THAYALAN
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.