CAS: 65352-94-5; 6-Fluoronicotinoyl Chloride

上下游产品

6-fluoronicotinic acid (5-methyl-pyridin-2-yl)amine 2-fluoro-5-methylpyridine oxalyl dichloride pyrrolidine-2-carboxylic acidN-(2-fluoropyridin-5-yl)carbonylpyrrolidine-2-carboxylic acid N-[3-(9-chloro-3-methyl-4-oxo-5H-isoxazolo[4,5-c]quinolin-5-yl)-cyclohexylmethyl]-6-fluoro-nicotinamide (R)-4-[5-(4-bromo-3,5-difluoro-phenylcarbamoyl)pyridin-2-yl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester N-(4-Bromo-3-methyl-phenyl)-6-fluoro-nicotinamide

2-氟-5-甲基吡啶置于potassium Permanganate,氯化亚砜体系中,用 二氯甲烷 作为反应溶剂,化学反应 5.0H,反应生成 2-氟吡啶-5-甲酰氯
参考文献:Rapid And Efficient Synthesis Of [18F]Fluoronicotinamides,[18F]Fluoroisonicotinamides And [18F]Fluorobenzamides As Potential Pet Radiopharmaceuticals For Melanoma Imaging
标题:Rapid And Efficient Synthesis Of [18F]Fluoronicotinamides,[18F]Fluoroisonicotinamides And [18F]Fluorobenzamides As Potential Pet Radiopharmaceuticals For Melanoma Imaging
摘要:为了简化亲核性放射氟化反应以适应自动化需求,使用一步合成法,通过在三甲基铵基烟酰胺,三甲基铵基异烟酰胺和三甲基铵基苯甲酰胺前体上的取代反应,合成了一系列的[18F]氟烟酰胺,[18F]氟异烟酰胺和[18F]氟苯甲酰胺.基于起始的[18F]氟化物,发现在20分钟的合成时间内,放射化学产率和纯度分别大于90%和97%,并且无需高效液相色谱纯化.这种合成方法非常有前景,作为一种快速且简单的方法,用于[18F]氟烟酰胺,[18F]氟异烟酰胺和[18F]氟苯甲酰胺的自动化放射氟化,具有高放射化学产率和非常短的制备时间.版权所有 © 2011 John Wiley & Sons,Ltd.
DOI:10.1002/jlcr.1869

专利信息

专利号:US-9221821-B2
优先权日:2012-06-05
标题:Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds
发明人：DIEP NHUT; KALYAN YURIY B
权利人:FOREST LAB HOLDINGS LTD; FOREST LAB HOLDINGS LTD
摘要:Methods for the synthesis of disubstituted aminouracils and xanthine and/or xanthine-related compounds are provided.

专利号:US-2024400552-A1
优先权日:2016-11-11
标题 :Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11622968-B2
优先权日:2011-03-08
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11034690-B2
优先权日:2016-11-11
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC; SAGINIET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-9809591-B2
优先权日:2011-03-08
标题 :Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W
权利人:3-V BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

专利号:US-2013324724-A1
优先权日:2012-06-05
标题 :Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds