CAS: 638-65-3; Octadecanenitrile

上下游产品

thiostearamide is°Cyanuric acid stearic acid urea2,4-diamino-6-heptadecyl-symm-triazine 1-phenyl-eicosan-3-one bis-stearoylamino-methane 1-[2]naphthyl-°Ctadecan-1-one

📜硬脂酸置于[双(2-甲氧基乙基)胺]三氟化硫 Sodium Azide,三乙胺,三苯基膦体系中,用 二氯甲烷,二甲基亚砜 作为反应溶剂,化学反应 0.5H,以91%的收率获得产物十八烷腈
参考文献:使用双(2-甲氧基乙基)氨基三氟化硫直接,轻松地从羧酸合成酰基叠氮化物和腈
标题:使用双(2-甲氧基乙基)氨基三氟化硫直接,轻松地从羧酸合成酰基叠氮化物和腈
摘要:描述了一种温和,有效和实用的方法,用于使用双(2-甲氧基乙基)氨基三氟化硫从羧酸一步合成酰基叠氮化物.通过包含磷试剂,该反应易于扩展至相应腈的合成.该方法可用于高产率地合成旋光腈,并且与氟代膦酸酯相容.
DOI:10.1016/j.Tetlet.2007.06.119

专利信息

专利号:US-3673250-A
优先权日:1970-12-01
标 题 :Catalytic hydration of nitriles to produce amides
发明人：RAUCH FRANCIS CLYDE; NACHTIGALL GUENTER WILLI
权利人:AMERICAN CYANAMID CO
摘要:Catalytic hydration of a nitrile with water in presence of a homogeneous catalyst in solution with the reactants, is described for the synthesis of an amide. The catalyst comprises two components, one a transition metal compound such as a rhodium compound, the other an organic phosphite, phosphine, arsenite, arsine, stibine or antimonite. One preferred example is rhodium trichloride with triphenyl phosphine as a catalyst for hydration of acrylonitrile to acrylamide. Some complexing of the solution components is suggested. In some embodiments, presence of a further component such as triphenyl phosphine oxide will improve the process.

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:US-3674848-A
优先权日:1970-08-19
标题 :Hydration of nitriles using metal salts of cation exchange resins
发明人：SCHOENBRUNN ERWIN FREDERICK; SINHA VINOD TARKESHWAR
权利人:AMERICAN CYANAMID CO
摘要:Solid catalysts for hydration of nitriles to amides comprise metal salts of cation exchange resins. Group I B and II B metals are used with either strong acid or weak acid cation exchange resins. A variety of organic nitriles may be used in the process. Detailed examples describe preparation of several catalysts and the synthesis of acrylamide, acetamide and benzamide. The reactants in liquid solution are contacted with the solid catalyst at 70* - 180* C.

专利号:US-7432031-B2
优先权日:2005-03-22
标 题:Toner for electrostatic charge developing, production method thereof, developer for electrostatic charge developing using the same, and image forming method
发明人：MIZUTANI NORIYUKI; MAEHATA HIDEO; HAMANO HIROKAZU; TANAKA HIROYUKI; KITAGAWA SOICHIRO; IGUCHI MOEGI
权利人:FUJI XEROX CO LTD
摘要:A toner for electrostatic charge developing prepared by a production method including aggregating one or more kind of particles in a raw material dispersion including the particles to form aggregated particles, and coalescing the aggregated particles by heating. At least one kind of the particles is resin particles including an amorphous polyester resin synthesized by copolymerizing one or more polyvalent carboxylic acids and two or more polyhydric alcohols; at least one of the polyvalent carboxylic acids is polyvalent carboxylic acid having a sulfonic acid group; two of the polyhydric alcohols are an ethylene oxide adduct of bisphenol A and a propylene oxide adduct of bisphenol A; and the following equation is satisfied:n n10/90≦ BPA ( EO )/ BPA ( PO )≦90/10.n n In the equation, BPA(EO) represents a total mole amount of the ethylene oxide adduct of bisphenol A used in synthesis of the amorphous polyester resin, and BPA(PO) represents a total mole amount of the propylene oxide adduct of bisphenol A used in synthesis of the amorphous polyester resin.

专利号:US-2021130270-A1
优先权日:2018-07-16
标 题 :Synthesis of straight-chain lepidopteran pheromones through one- or two- carbon homologation of fatty alkenes

专利号:JP-2014523441-A
优先权日:2011-07-19
标题:Process for the synthesis of functionalized omega-acids from fatty acids or fatty acid esters