专利号:US-10925977-B2 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications 发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S 权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS 摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:KR-101513003-B1 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy compositions and applications
专利号:AU-2007308022-A2 优先权日:2006-10-05 标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A1 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:US-2008107598-A1 优先权日:2006-10-05 标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications
专利号:AU-2007308022-B2 优先权日:2006-10-05 标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
1: Hampton J. Therapeutic fashion and publication bias: the case of anti-arrhythmic drugs in heart attack. J R Soc Med. 2015 Oct;108(10):418-20. doi: 10.1177/0141076815608562. German. doi: 10.1124/jpet.113.208892. Epub 2013 Nov 7. doi: 10.1136/bmj.h287. German. Review. Review. Review. Review. Review. Review.
合成参考文献
参考文献:10.1007/s00108-006-1612-0 摘要:Seiderer J, Rust C, Menth M, Pusl T, Jung M. [A 67-year-old patient with somnolence and severe hyponatraemia]. Internist (Berl). 2006 Jun;47(6):623–4, 626. doi: 10.1007/s00108-006-1612-0. 参考文献:10.1007/bf00804330 摘要:Weirich J. Frequency-dependent action of antiarrhythmic drugs: the useful concept of periodical ligand binding. Basic Res Cardiol. 1992 May;87(3):205–14. doi: 10.1007/bf00804330. 参考文献:10.1007/bf03033199 摘要:Dave JR, Lin Y, Ved HS, Koenig ML, Clapp L, Hunter J, Tortella FC. RS-100642-198, a novel sodium channel blocker, provides differential neuroprotection against hypoxia/hypoglycemia, veratridine or glutamate-mediated neurotoxicity in primary cultures of rat cerebellar neurons. Neurotox Res. 2001 Aug;3(4):381–95. doi: 10.1007/bf03033199.