CAS: 56558-16-8; 2,2',4,6,6'-Pentachloro-1,1'-Biphenyl
该化合物是一种氯化联苯化合物,其特征为2,2',4,6,6'和6'位置的5个氯替代体,这种配置具有很高的化学稳定性和抗降解性,使其在需要惰性材料的专门工业应用中有用.其明确界定的结构使得在环境测试中,特别是在多氯联苯污染研究中,可以精确地分析参考标准.该化合物的持久性和亲脂性也使得毒理学研究中了解氯化联苯对环境的影响具有相关性.由于它具有潜在的生物累积性和危险特性,因此,根据多氯联苯管理的管理准则,谨慎处理至关重要.
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: MTCPZNVSDFCBBE-UHFFFAOYSA-N
- 1S/C12H5Cl5/c13-6-4-9(16)12(10(17)5-6)11-7(14)2-1-3-8(11)15/h1-5H
- 计算化学: 氢键受体数*氢键供体数0可旋转键数1
MSDS等安全信息
- GHS符号GHS07
- 警示词Warning
- 危险描述H302-H315-H319-H335
- 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
- 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
上下游产品
2,2',6,6'-tetrachlorobiphenyl 1,3,6,9-tetrachlorodibenzofuran 1,3,4,9-tetrachlorodibenzofuran合成工艺路线路线简述
📜2,6-二氯苯胺置于三氯化铝,磺酰氯,硫酸,铜,Potassium Iodide,Sodium Nitrite体系中,用 二氯甲烷 作为反应溶剂,化学反应 290.42H,反应生成 2,2',4,6,6'-五氯联苯
参考文献:Improved Syntheses Of 2,2',3,3',6,6'-Hexachlorobiphenyl
标题:Improved Syntheses Of 2,2',3,3',6,6'-Hexachlorobiphenyl
摘要:
DOI:10.1080/00304949709355248
海关参考信息
- 2903919090-氯苯
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
参考文献:10.1007/s002449900499
摘要:Andersson PL, Blom A, Johannisson A, Pesonen M, Tysklind M, Berg AH, Olsson P-, Norrgren L. Assessment of PCBs and Hydroxylated PCBs as Potential Xenoestrogens: In Vitro Studies Based on MCF-7 Cell Proliferation and Induction of Vitellogenin in Primary Culture of Rainbow Trout Hepatocytes. Archives of Environmental Contamination and Toxicology. 1999 Aug 01;37(2):145–50. doi: 10.1007/s002449900499.
参考文献:10.1016/j.yexcr.2004.01.030|10.1016/s0014-4827(04)00066-7
摘要:Eum SY, Lee YW, Hennig B, Toborek M. VEGF regulates PCB 104-mediated stimulation of permeability and transmigration of breast cancer cells in human microvascular endothelial cells. Exp Cell Res. 2004 Jun 10;296(2):231–44. doi: 10.1016/j.yexcr.2004.01.030.
参考文献:10.1158/1541-7786.mcr-05-0119
摘要:Eum SY, Lee YW, Hennig B, Toborek M. Interplay between epidermal growth factor receptor and Janus kinase 3 regulates polychlorinated biphenyl-induced matrix metalloproteinase-3 expression and transendothelial migration of tumor cells. Mol Cancer Res. 2006 Jun;4(6):361–70. doi: 10.1158/1541-7786.mcr-05-0119.
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