CAS: 55750-61-3; 2,5-Dioxopyrrolidin-1-Yl 2-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-yl)Acetate

相似化合物

80307-12-6 55750-62-4 103750-03-4

上下游产品

CAS号6066-82-6 N-羟基琥珀酰亚胺 | CAS号25021-08-3 2-马来酰亚胺基乙酸 | CAS号54930-24-4 N-羧甲基马来酰胺酸

4-[(Carboxymethyl)Amino]-4-Oxo-2-Butenoic Acid置于草酰氯,三乙胺,对硝基三氟乙酸苯酯体系中,用 二氯甲烷 作为反应溶剂,化学反应 7.0H,反应生成 马来酰亚胺基乙酸琥珀酰亚胺酯
参考文献:合成n-马来酰亚胺基烷基酸及其琥珀酰亚胺 酯的方法
标题:合成n-马来酰亚胺基烷基酸及其琥珀酰亚胺 酯的方法
摘要:本发明提供了一种合成n‑马来酰亚胺基烷基酸及其琥珀酰亚胺酯的方法,该方法包括以下步骤:(A)式(II)化合物与4‑硝基三氟乙酸苯酯在碱存在的条件下,在有机溶剂中发生关环反应,得到式(Iii)的n‑马来酰亚氨基烷基酸;及(B)式(Iii)的n‑马来酰亚氨基烷基酸与酰化试剂在有机溶剂中,在回流温度下反应得到(Iv)的酰氯中间体,(Iv)的酰氯中间体与n‑羟基琥珀酰亚胺在有机溶剂中,在碱存在的条件下发生反应,得到式(V)的n‑马来酰亚胺基烷基酸琥珀酰亚胺酯.该方法工艺简单,收率高,且产品纯度高,适合工业化生产.反应路线如下:

专利信息

专利号:WO-03064360-A1
优先权日:2002-02-01
标 题:Synthetic tetraethers and synthesis strategies therefor
发明人：KUEHL CHRISTINE; LITTGER RALF
权利人:BERNINA BIOSYSTEMS GMBH; KUEHL CHRISTINE; LITTGER RALF
摘要:The invention relates to novel synthetic tetraethers and a novel method for producing said substances. The inventive tetraethers are characterised in that they can be modified in a simple and targeted manner according to said synthesis method, which enabling the synthesis of the desired model substances. The synthesis concept guarantees high variability with simple individual production.

专利号:US-10254287-B2
优先权日:2015-07-21
标题 :Protein fluorescent nanoparticles and methods of synthesis thereof
发明人：KUMAR CHALLA VIJAYA; STROMER BOBBI SHANYELLE
权利人:UNIV CONNECTICUT
摘要:Disclosed herein are stable and versatile protein nanoparticles having a range of tunable fluorescent properties. Such nanoparticles may find utility in biological imaging. Methods of synthesis of such nanoparticles are also disclosed.

专利号:US-9012648-B2
优先权日:2012-08-21
标题 :Haptens of risperidone and paliperidone
发明人：HASPESLAGH PIETER RIK; VLIEGEN MAARTEN; HRYHORENKO ERIC; DECORY THOMAS R; SANKARAN BANUMATHI
权利人:JANSSEN PHARMACEUTICA NV; ORTHO CLINICAL DIAGNOSTICS INC
摘要:The invention relates to compounds of Formula I, wherein R1 and R2 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from risperidone and paliperidone. The invention also relates to conjugates of a risperidone or paliperidone hapten and a protein.

专利号:US-9303041-B2
优先权日:2012-08-21
标题 :Haptens of olanzapine
发明人：DONAHUE MATTHEW GARRETT; GONG YONG; SALTER RHYS; HRYHORENKO ERIC; DECORY THOMAS R; REMMERIE BART; SANKARAN BANUMATHI
权利人:JANSSEN PHARMACEUTICA NV; ORTHO CLINICAL DIAGNOSTICS INC
摘要:The invention relates to compounds of Formula I, wherein R 1 , R 2 , and R 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from olanzapine. The invention also relates to conjugates of an olanzapine hapten and a protein.

专利号:US-9795685-B2
优先权日:2012-08-21
标 题 :Haptens of aripiprazole
发明人：LIN RONGHUI; SALTER RHYS; DECORY THOMAS R; HRYHORENKO ERIC; REMMERIE BART M; SANKARAN BANUMATHI
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention relates to compounds of Formula I, wherein R 1 , R 2 , and R 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from aripiprazole. The invention also relates to conjugates of an aripiprazole hapten and a protein.

专利号:US-2022135614-A1
优先权日:2019-03-04
标题:Synthesis of bicycle toxin conjugates, and intermediates thereof
发明人：TEUFEL DANIEL
权利人:BICYCLERD LTD
摘要:The present invention relates to Bicycle toxin conjugates, methods for preparation, and methods of use for treating cancer.