CAS: 5334-43-0; 5-Amino-1-Phenyl-1H-Pyrazole-4-Carbonitrile

上下游产品

phenylhydrazine Ethoxymethylenemalononitrile 3-amino-3-(o-aminoanilino)-2-cyano-2-propenal phenylhydrazone 2-Amino-3-(2-ethylbenzimidazol-1-yl)-2-(2-phenyl-1,1-diazanediylmethyl)-2-propenenitrile N-(4-cyano-1-phenyl-1H-pyrazol-5-yl)acetamide 1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 5-amino-1-phenyl-1H-pyrazole-4-carboxamide 4-Cyano-1-phenyl-5-(1-pyrryl)pyrazole

📜1-[4-Cyano-1-Phenyl-1H-Pyrazol-5-Ylaminocarbonylmethyl]Pyridinium Chloride置于potassium Tert-Butylate体系中,用 叔丁醇 作为反应溶剂,化学反应 24.0H,以0.18 G的收率获得产物5-氨基-1-苯基吡唑-4-腈
参考文献:新型杂环系统吡唑并[3,4-B]吡啶并[1',2':1,2]咪唑并[4,5-D]吡啶衍生物的合成
标题:新型杂环系统吡唑并[3,4-B]吡啶并[1',2':1,2]咪唑并[4,5-D]吡啶衍生物的合成
摘要:摘要1-[4-氨基芳基吡唑并[3,4-B]吡啶-5-基]吡啶鎓在过量叔丁醇钾存在下在叔丁醇中回流环化,形成吡唑并[3,4]的四环衍生物-B]吡啶并[1',2':1,2]咪唑并[4,5-D]吡啶.提出了这些过程的反应方案.反应产物的结构通过物理化学方法确定.
DOI:10.1007/s11172-006-0322-Z

专利信息

专利号:US-2008096868-A1
优先权日:2004-11-12
标题:1,4 Substituted Pyrazolopyrimidines as Kinase Inhibitors
发明人：SCHMIEDEBERG NIKO; FURET PASCAL; IMBACH PATRICIA; HOLZER PHILIPP
权利人:SCHMIEDEBERG NIKO; FURET PASCAL; IMBACH PATRICIA; HOLZER PHILIPP
摘要:The invention relates to 1,4-substituted pyrazolopyrimidine compounds of the formula I, n npharmaceuticals comprising a 1,4-substituted pyrazolopyrimidine compound, the use of a 1,4-substituted pyrazolopyrimidine compound in the treatment or the use thereof in the manufacture of a pharmaceutical formulation for the treatment of a disease that depends on inadequate activity of a protein kinase, methods of treatment comprising administering a 1,4-substituted pyrazolopyrimidine compound, methods for the manufacture of a novel compound of that class, and novel intermediates and partial steps for their synthesis.