CAS: 53179-09-2; Bis((2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-4,6-Diamino-3-(((2S,3R)-3-Amino-6-(Aminomethyl)-3,4-Dihydro-2H-Pyran-2-yl)Oxy)-2-Hydroxycyclohexyl)Oxy)-5-Methyl-4-(Methylamino)Tetrahydro-2H-Pyran-3,5-Diol) Pentakis(Sulfate)

该化合物是一种主要用于治疗古性细菌感染的抗生素,主要用于治疗古代阴性细菌的感染,其来源是微米松索拉净尿的发酵,并展示了广泛的抗菌活动.通过抑制细菌蛋白合成,具体针对30S 脊髓炎亚元素的阻塞性功能,这扰乱了翻译过程并最终导致细胞死亡.该化合物一般会通过循环施用,因为其口服生物利用率低.通过硫酸形式,其溶液在水中的可溶性会增强,使之适合静脉注射使用.Sisomica素因其潜在的肾脏毒性和食毒性而闻名,这需要认真监测接受治疗的病人的肾功能和听力.此外,如果与其他抗生素结合使用,可能会产生协同效应,增强抗抗菌菌菌株的功效.与其他微分分泌物相类似,可能需要对肾脏损伤病人的剂量进行调整,以尽量减少不利影响的风险.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号32385-11-8 西索米星

合成工艺路线路线简述

    📜西索米星,甲烷,硫酸置于ion,水,甲醇,硫酸西梭霉素,四磷十氧化物体系中,用 Ion,水 作为反应溶剂,化学反应 0.5H,以to Obtain A Level Of Ph 4.3的收率获得产物硫酸西梭霉素
    参考文献:Micromonospora Culture
    标题:Micromonospora Culture
    摘要:Micromonospora Danubiensis是一种新物种,具有产生sisomicin的能力.

    海关参考信息

    专利信息


    专利号:US-9693999-B2
    优先权日:2011-01-26
    标题:Small molecule RNase inhibitors and methods of use
    发明人:DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE
    权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education
    摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

    专利号:WO-2009056955-A1
    优先权日:2007-10-30
    标题 :Amine-bearing phospholipids (abps), their synthesis and use
    发明人:ZUMBUEHL ANDREAS
    权利人:UNIV BASEL; ZUMBUEHL ANDREAS
    摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

    专利号:US-9868747-B2
    优先权日:2014-02-18
    标题:Marinopyrrole derivatives and methods of making and using same
    发明人:LI RONGSHI; SEBTI SAID; LIU YAN; QIN YONG; SONG HAO; CHENG CHUNWEI
    权利人:H LEE MOFFITT CANCER CT & RES; CHONGQING ZEIN PHARMACEUTICAL CO LTD
    摘要:Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.

    专利号:US-9907753-B2
    优先权日:2010-03-19
    标 题 :Lipid vesicle compositions and methods of use
    发明人:IRVINE DARRELL J; MOON JAEHYUN
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

    专利号:CN-115612114-A
    优先权日:2021-07-14
    标 题:Method and application of copolymer film and its enzymatic self-assembly synthesis

    专利号:US-6911318-B2
    优先权日:1999-03-03
    标 题:Bacterial transglycosylases: assays for monitoring the activity using Lipid II substrate analogs and methods for discovering new antibiotics
    发明人:KAHNE SUZANNE WALKER
    权利人:UNIV PRINCETON
    摘要:This invention provides a direct method for monitoring bacterial transglycosylase activity using labeled substrates produced by chemo-enzymatic synthesis wherein the labels are selected to permit the detection of both polymeric and non-polymeric products simultaneously, either directly or following the separation of product from starting material. The invention promotes the discovery of new antibiotics with activity against bacterial transglycosylases by a) laying the groundwork for structural analysis of purified, active transglycosylase (which permits structure-based design); and b) providing an assay that can be used to screen for inhibitors.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Guan S, Li Y, Cheng C, Gao X, Gu X, Han X, Ye H. Manufacture of pH- and HAase-responsive hydrogels with on-demand and continuous antibacterial activity for full-thickness wound healing. Int J Biol Macromol. 2020 Dec 1;164:2418-2431. doi: 10.1016/j.ijbiomac.2020.08.108. Epub 2020 Aug 13. 16(5):445-7. Chinese. 181(4):471-3. doi: 10.1620/tjem.181.471. 22(2):123-7. doi: 10.1159/000267011. 37(7):1237-40. Japanese. 28(9):678-82. Russian. 17(1):67-71. doi: 10.1016/0300-483x(80)90028-1. 32(4):387-96. Spanish. 43(7-8):258-60. Spanish.

    合成参考文献


    摘要:Drugs in Japan, 6(320), 1982
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