CAS: 521974-00-5; Tert-Butyl 2-((4S,6S)-6-(Chloromethyl)-2,2-Dimethyl-1,3-Dioxan-4-yl)Acetate

英文名称Tert-Butyl 2-((4S,6S)-6-(Chloromethyl)-2,2-Dimethyl-1,3-Dioxan-4-yl)Acetate
中文名称罗舒伐他汀杂质50
IUPAC名称tert-butyl 2-((4S,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
其它别名Rosuvastatin Related Compound 7; Rosuvastatin Impurity 95; 1,3-Dioxane-4-Acetic Acid, 6-(Chloromethyl)-2,2-Dimethyl-, 1,1-Dimethylethyl Ester, (4S,6S)-; Tert-Butyl 2-((4S,6S)-6-(Chloromethyl(02,2-1,3-Dioxan-4-yl)Acetate; Tert-Butyl 2-((4S,6S)-6-(Chloromethyl(02,; Tert-Butyl 2-((4S,6S)-6-(Chloromethyl)-2,2-Dimethyl-1,3-Dioxan-4-yl)Acetate (Rosuvastatin Impurity）
CAS编号521974-00-5
FDA UNII编号:M82M9EQ9UY
分子式:C13H23ClO4分子量:278.78
产品CID: 1512844

相似结构搜索
InChIKey: TXLXWCARAPIXGH-UWVGGRQHSA-N
InChI=1S/C13H23ClO4/c1-12(2,3)18-11(15)7-9-6-10(8-14)17-13(4,5)16-9/h9-10H,6-8H2,1-5H3/t9-,10-/m0/s1
计算化学: 氢键受体数*氢键供体数*可旋转键数*

MSDS等安全信息

上下游产品

2,2-dimethoxy-propane 1,1-dimethylethyl (3R,5S)-6-chloro-3,5-dihydroxy-4-hexanoate tert-butyl (5S)-6-chloro-3,5-dihydroxyhexanoate tert-butyl acetoacetate[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate (4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester

合成工艺路线路线简述

海关参考信息

2905122000-异丙醇
2905143000-叔丁醇
2905399001-1,3-丙二醇
2905590020-2-氯乙醇
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专利信息

专利号:WO-2014203045-A1
优先权日:2013-06-20
标题:A novel, green and cost effective process for synthesis of tert-butyl (3r,5s)-6-oxo-3,5-dihydroxy-3,5-o-isopropylidene-hexanoate
发明人：ROY BHAIRABNATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; TRIVEDI ANURAG; PISE VIJAY SADASHIV; RUPANWAR MANOJ
权利人:LUPIN LTD
摘要:The present invention provides a process of preparation of an intermediate useful for the preparation of statins more particularly the present invention relates to an eco-friendly and cost effective process for the preparation of tert -butyl (3R,5S)-6-oxo-3,5-dihydroxy- 3,5-O-isopropylidene-hexanoate [I].