CAS: 477535-41-4; 3-Bromo-5-(Trifluoromethyl)Benzaldehyde

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CAS号172023-97-1 3-溴-5-(三氟甲基)苄醇 | CAS号880652-44-8 3-bromo-N-metho... | CAS号626-41-5 3,5-二溴苯酚 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号328-67-6 3-溴-5-三氟甲基苯甲酸 | CAS号958258-15-6 3-Bromo-5-(trif...

📜3-溴-5-三氟甲基苯甲酸置于草酰氯,二异丁基氢化铝,三乙胺,N,N-二甲基甲酰胺体系中,用 四氢呋喃,二氯甲烷,甲苯 作为反应溶剂,化学反应 1.83H,反应生成 3-溴-5-(三氟甲基)苯甲醛
参考文献: Novel Neurokinin 1 Receptor Antagonist Compounds[fr] Nouveaux Composés Antagonistes Du Récepteur De La Neurokinine 1
标题: Novel Neurokinin 1 Receptor Antagonist Compounds[fr] Nouveaux Composés Antagonistes Du Récepteur De La Neurokinine 1
摘要:本发明涉及一种根据公式(a)的化合物,其中n为1或2;r1和r2独立为氢,C1-4烷基,C1-4卤代烷基,C1-4烷氧基,Cd3或卤素;r3为氢,C(=o)Or7或c1-4烷基,可选地被羟基或nr8R9取代;r4为氢或氧代;r5和r6独立为氢,羟基,Nr8R9,C(=o)R7,C(=o)Or7,C(=o)Nr8R9,C1-4烷基,其中所述c1-4烷基可选地被羟基,Nr8R9或5-或6-成员的杂环环取代,其中所述5-或6-成员的杂环环可选地被c1-4烷基或c(=o)R7取代;或r5和r6与它们所连接的碳原子一起形成=ch2或5-或6-成员的杂环烷基,其中所述杂环烷基可选地被c1-4烷基取代;r7为氢或c1-4烷基;r8和r9独立为氢或c1-4烷基,或r8和r9与它们所连接的氮原子一起形成一个5-或6-成员的杂环环,或其药用可接受的盐或溶剂化物.本发明进一步涉及用于制备所述化合物的中间体,所述化合物用于治疗,包含所述化合物的药物组合物,使用所述化合物治疗或改善瘙痒性皮肤病或状况的方法,以及所述化合物在药物制造中的用途.

专利信息

专利号:US-12304912-B2
优先权日:2020-07-28
标 题 :Fused bicyclic RAF inhibitors and methods for use thereof
发明人：BELFIELD ANDREW; JONES CLIFFORD DAVID; MARGATHE JEAN-FRANÇOIS; COLLETTO CHIARA
权利人:JAZZ PHARMACEUTICALS IRELAND LTD
摘要:The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitors of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The disclosure also relates to method of using the compound of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.

专利号:US-12227528-B2
优先权日:2017-11-09
标 题:Glucose-sensitive albumin-binding derivatives
发明人：KRUSE THOMAS; KOFOD-HANSEN MIKAEL; MUENZEL MARTIN WERNER BORCHSENIUS; THOEGERSEN HENNING; SAUERBERG PER; EWALD JAKOB; BEHRENS CARSTEN; HOEG-JENSEN THOMAS; BALSANEK VOJTECH; DROBNAKOVA ZUZANA; DROZ LADISLAV; HAVRANEK MIROSLAV; KOTEK VLADISLAV; STENGL MILAN; SNAJDR IVAN; DRUSANOVA HANA
权利人:NOVO NORDISK AS
摘要:This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.

专利号:US-9446047-B2
优先权日:2013-09-10
标 题 :Substituted 2,3-dihydro-1H-inden-1-one retinoic acid-related orphan nuclear receptor antagonists for treating multiple sclerosis
发明人：VANKAYALAPATI HARIPRASAD; YERRAMREDDY VENKATAKRISHNAREDDY
权利人:ARRIEN PHARMACEUTICALS LLC
摘要:The present invention is directed to compounds, their synthesis, and their use as antagonists, inverse agonists, modulators and or inhibitors of the Retinoic acid-related orphan nuclear receptor γt (RORγt)/RORγ. The compounds of the present invention are useful for modulating RORγt)/RORγ activity and for treating diseases or conditions mediated by RORγt)/RORγ such as for example, disease states associated with immunopathology of human autoimmune diseases such as Multiple Sclerosis (MS), Rheumatoid Arthritis (RA), Inflammatory Colitis, Psoriasis, COPD, Pain, Obesity, Diabetes, Dyslipidemia, Osteoporosis, Asthma, Neurodegenerative diseases and Cancer.