CAS: 36590-19-9; 4-Methyl-Piperazine-1-Carbothioic Acid [4-(4-Nitro-Phenylamino)-Phenyl]-Amide
- 英文名称4-Methyl-Piperazine-1-Carbothioic Acid [4-(4-Nitro-Phenylamino)-Phenyl]-Amide
- 中文名称4-甲基-N-[4-[(4-硝基苯基)氨基]苯基]-1-哌嗪硫代甲酰胺
- IUPAC名称4-methyl-N-(4-((4-nitrophenyl)amino)phenyl)piperazine-1-carbothioamide
- 其它别名Am°Carzine; Phenthiourezine
- CAS编号36590-19-9
- FDA UNII编号:99807U412Y
- 分子式:C18H21N5O2S分子量:371.46
- 产品CID: 1375220
- 产品分类有机原料 → 苯类化合物 → 苯和取代衍生物
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2921211000-乙二胺
2921440000-二苯胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-5278181-A
优先权日:1992-05-12
标 题 :Soluble alkyl[5-[amino (phenyl)methyl]-1H-benzimidazol-2-yl] carbamate anthelmintics
发明人：TOWNSEND LEROY B; WISE DEAN S; RAM SIYA
权利人:REGENTS ACTING ON BEHALF OF TH
摘要:Soluble alkyl (5-(amino (phenyl)methyl)-2H-benzimidazol-2-yl)carbamates, their enantiomorphic forms, and acid addition salts thereof are well absorbed and possess curative anthelmintic activity, especially against filarial worms, when administered orally or parenterally. Pharmaceutical compositions containing the compounds and methods of employing the compounds in methods of treating helminth infections in mammals are also disclosed, together with methods of synthesis.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
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主要参考文献
1: Awadzi K, Opoku NO, Attah SK, Addy ET, Duke BO, Nyame PK, Kshirsagar NA. The safety and efficacy of amocarzine in African onchocerciasis and the influence of ivermectin on the clinical and parasitological response to treatment. Ann Trop Med Parasitol. 1997 Apr;91(3):281-96.
9: Poltera AA, Zea-Flores G, Guderian R, Beltranena F, Proana R, Moran M, Zak F, Striebel HP. Onchocercacidal effects of amocarzine (CGP 6140) in Latin America. Lancet. 1991 Mar 9;337(8741):583-4.
11: Poltera AA, Reyna O, Zea-Flores G, Beltranena F, Nowell de Arevalo A, Zak F. Use of an ophthalmologic ultrasoundscanner in human onchocercal skin nodules for non-invasive sequential assessment during a macrofilaricidal trial with amocarzine in Guatemala. The first experiences. Trop Med Parasitol. 1991 Sep;42(3):303-7.
合成参考文献
参考文献:10.1007/s10903-023-01578-y
摘要:Herrera-Añazco P, Benites-Meza JK, Caira-Chuquineyra B, Fernandez-Guzman D, Hernandez-Bustamante EA, Benites-Zapata VA. Ethnic Minority Participation in Clinical Trials from Latin America and the Caribbean: A Scoping Review. J Immigr Minor Health. 2024 Jun;26(3):604–22. doi: 10.1007/s10903-023-01578-y.
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