CAS: 2571-22-4; Tutin
该化合物是一种自然发生的化合物,被归类为内酯,这是一种循环酯,由酒精和碳酸凝结形成,主要来自科里亚人基因中的植物,以其毒性为名,该化合物具有独特的结构,有助于其生物活动,包括潜在的毒性,其特点是它与生物系统相互作用的能力,如果被摄取,可能导致不利影响.该化合物因其对细胞过程的影响,在药理学和毒理学领域引起了兴趣.此外,该化合物还可能对天然产品及其药用化学衍生物的研究产生影响.然而,由于其毒性性质,处理和使用需要谨慎,必须开展进一步的研究,以充分了解其特性和潜在用途.
- ⚠️危险化学品目录(2015年版) 急性毒性-经口,类别2
- 英文名称Tutin
- 中文名称羟基马桑毒内酯
- IUPAC名称(1a'S,1b'R,2R,2'S,5'R,6'S,6a'R,7a'R,8'R)-1b',6'-dihydroxy-6a'-methyl-8'-(prop-1-en-2-yl)hexahydrospiro[oxirane-2,7'-[2,5]methanooxireno[2',3':3,4]cyclopenta[1,2-d]oxepin]-3'(2'H)-one
- 其它别名TUTIN; (7R,8R)-1aβ,1b,5,6,6a,7aβ-Hexahydro-1bα,6β-dihydroxy-6aα-methyl-8-(1-methylethenyl)spiro[2α,5α-methano-7H-oxireno[3,4]cyclopent[1,2-d]oxepine-7,2'-oxiran]-3(2H)-one; (1As-(1aalpha,1bbeta,2beta,5beta,6alpha,6abeta,7beta,7aalpha,8S*))-hexahydro-1B,6-dihydroxy-6A-methyl-8-(1-methylethenyl)spiro(2,5-methano-7H-oxireno(3,4)cyclopent(1,2-D)oxepin-7,2'-oxiran)-3(2alpha H)-one; Spiro(2,5-methano-7H-oxireno(3,4)cyclopent(1,2-D)oxepin-7,2'-oxiran)-3(2ah)-one, 1A-beta,1B,5A,6,6A,7A-beta-hexahydro-1B-alpha,6-beta-dihydroxy-8A-isopropenyl-6A-alpha-methyl-; Toot poison; Tutine; Tutu
- CAS编号2571-22-4
- EINECS号:808-861-1
- FDA UNII编号:B69P754702
- 分子式:C15H18O6分子量:294.3
- 产品CID: 1221244
- 产品分类有机原料 → 有机杂环化合物 → 内酯类
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
2,2,2-trichloroethoxycarbonyl α-bromotutin 15H20Br2O3C15H20Br2O3 17H21BrO5C17H21BrO5 21H34Br2O3SiC21H34Br2O3Si合成工艺路线路线简述
📜(((2S,3S,4S,5As,8S,8Ar,9R)-2,6-Bis(Bromomethyl)-2,5A-Dimethyl-2,3,4,5,5A,8-Hexahydro-4,3,8A-(Epoxyethane[1,2,2]Triyl)Cyclopenta[b]Oxepin-8-yl)Oxy)(Tert-Butyl)Dimethylsilane置于lead(Iv) Acetate,二环己烷并-18-冠醚-6,Ruthenium Trichloride,Potassium Superoxide,Sodium Periodate,Disodium Hydrogenphosphate,Phosphate Buffer,Calcium Hydride,三氟过氧乙酸,四丁基氟化铵,四丁基溴化铵,Potassium Carbonate,氯化铵,锌体系中,用 四氢呋喃,吡啶,甲醇,四氯化碳,乙醇,二氯甲烷,二甲基亚砜,N,N-二甲基甲酰胺,乙腈,苯 用作溶剂,化学反应 66.75H,反应生成羟基马桑毒内酯
参考文献:Stereocontrolled Total Synthesis Of (+)-Tutin And (+)-Asteromurin A,Toxic Picrotoxane Sesquiterpenes
标题:Stereocontrolled Total Synthesis Of (+)-Tutin And (+)-Asteromurin A,Toxic Picrotoxane Sesquiterpenes
摘要:
Doi:10.1016/s0040-4020(01)88159-X
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905143000-叔丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:TW-387903-B
优先权日:1996-06-28
标 题 :Vapor phase synthesis of rubbery polymers
专利号:US-10040698-B2
优先权日:2015-05-14
标题:Synthesis and characterization of a new series of cross-linked (phenol, formaldehyde, alkyldiamine) terpolymers for the removal of toxic metal ions from wastewater
专利号:US-2016332893-A1
优先权日:2015-05-14
标题 :Synthesis and characterization of a new series of cross-linked (phenol, formaldehyde, alkyldiamine) terpolymers for the removal of toxic metal ions from wastewater
专利号:CA-3096084-A1
优先权日:2008-04-08
标题:Triterpene saponins, methods of synthesis, and uses thereof
专利号:JP-S58501406-A
优先权日:1981-08-21
标题 :Increased expression of protein synthesis in Escherichia coli
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Watkins OC, Joyce NI, Gould N, Perry NB. Glycosides of the Neurotoxin Tutin in Toxic Honeys Are from Coriaria arborea Phloem Sap, Not Insect Metabolism. J Nat Prod. 2018 Apr 27;81(4):1116-1120. doi: 10.1021/acs.jnatprod.8b00120. Epub 2018 Mar 5. a plant-derived neurotoxin. Food Chem Toxicol. 2014 Oct;72:234-41. doi: 10.1016/j.fct.2014.07.032. Epub 2014 Jul 30. 56(3):341-6. Chinese. 60(2-3):453-9. doi: 10.1016/j.neuropharm.2010.10.023. Epub 2010 Oct 31. 78(6):1363-9. doi: 10.1021/acs.jnatprod.5b00241. Epub 2015 May 21. 131(1473):59-71. 559(1):61-4. doi: 10.1016/j.ejphar.2006.12.018. Epub 2007 Jan 17. 1092(1):207-13. doi: 10.1016/j.brainres.2006.03.081. Epub 2006 May 3. 15(12):1955-65. doi: 10.1248/cpb.15.1955. 42(3):295-301. Chinese.
63:419-23. doi: 10.1016/0006-8993(73)90116-9. 59(2):161-5. doi: 10.1248/cpb.59.161. 33(1):54-7. Chinese. 1(7864):996-7. doi: 10.1016/s0140-6736(74)91311-7. 22(1):35-8. Chinese. 48(3):337-41. doi: 10.3109/13880200903133837. 12(4):196-200. Chinese. 42(1):23-35. doi: 10.1142/S0192415X14500025. 24(2):152-5. Chinese. 81(2):373-80. doi: 10.1111/j.1476-5381.1984.tb10088.x.
合成参考文献
摘要:Journal of Medicinal Chemistry., 11(729), 1968
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