CAS: 23145-07-5; 5-Bromobenzofuran

相似化合物

128851-73-0 128868-60-0 133720-60-2

上下游产品

2,3-苯并呋喃 1-Benzofurane 271-89-6

4-溴-2-(2-硝基乙基)苯酚置于sodium Hydroxide,硫酸体系中,化学反应 0.5H,以68%的收率获得5-溴苯并呋喃
参考文献:一种高效全合成线性呋喃香豆素的新方法
标题:一种高效全合成线性呋喃香豆素的新方法
摘要:通过 Nef 反应和分子内环缩合在一个锅中合成线性呋喃香豆素的一种新方法导致苯并呋喃环的构建.该方法提供了一种轻松提供苯并呋喃骨架的新策略,并且还允许通过随后的 Pechmann 反应方便地合成香豆素环上具有不同取代基的呋喃香豆素衍生物.该策略也已应用于制备四种额外的苯并呋喃衍生物.
Doi:10.1055/s-2006-926250

专利信息

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-6465693-B2
优先权日:1998-02-26
标 题 :Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates
发明人：BUCHWALD STEPHEN L; WAGAW SEBLE; GEIS O
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A method is provided for the transition metal-catalyzed arylation, or vinylation, of hydrazines, hydrazones, and the like. Additionally, the invention provides a conceptually novel strategy, the cornerstone of which is the transition metal-catalyzed arylation or vinylation method, for the synthesis of indoles, carbazoles, and the like. The methods and strategies of the invention may be utilized in standard, parallel, and combinatorial synthetic protocols.

专利号:US-11053243-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9090661-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-5149838-A
优先权日:1991-09-20
标 题:Intermediates for substituted azetidinones useful as anti-inflammatory and antidegenerative agents
发明人：HUMPHREY GUY R; MADAR ANN M; THOMPSON ANDREW S
权利人:MERCK & CO INC
摘要:Disclosed is a process for the enantioselective synthesis of the compound of Formula I and related compounds. The process comprises the synthesis of the benzofuranyl carboxaldehyde; introduction of the benzylic amine functionality with control of the absolute stereochemistry; preparation of the azetidinone fragment and its coupling to the benzofuranyl amine fragments. The carboxylic acid in Formula I is liberated using heterogenous palladium catalyzed de-allylation of the allyl esters. Compounds I have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents. ##STR1##

专利号:CN-111039910-A
优先权日:2019-12-31
标题 :A kind of method and application of photo-initiated synthesis of 3-aryl flavonoids or coumarin compounds