CAS: 21617-18-5; 4,5-Dichloroquinoline

该化合物是一种环环环芳烃化合物,其特征是4和5个位置上有两个氯替代物的quinoline结构,该化合物一般是黄色的黄色至褐色固体,以水中的溶解性较低而著称,但可溶于乙醇和丙酮等有机溶剂,其分子配方为C9H6Cl2N,其双周期结构内含有氮原子,有助于其基本性和潜在再活动. 4,5-二氯基诺林因其潜在的生物活动,包括抗微生物和抗脉泡特性,在各个领域都具有兴趣,包括医药化学.此外,它可作为其他化学化合物合成的中间体.安全数据表明,应谨慎处理该物质,因为接触可能会对健康造成危害.建议在不相容物质冷干的地方适当储存,以保持其稳定性和完整性.

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4964-77-6 635-27-8 611-35-8

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上下游产品

5-chloro-4-hydroxyquinoline 5-chloro-4-hydroxy-quinoline-2-carboxylic acid 5-chloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester 3-chloro-aniline 5-chloro-1-(2-chloro-benzyl)-4-iodo-quinolinium; iodide N4,N4-diethyl-N1-(5-chloro-[4]quinolyl)-1-methyl-butanediyldiamineN4,N4-diethyl-N1-(5-chloro-[4]quinolyl)-1-methyl-butanediyldiamine 5-Chlor-4-amino-chinolin 4-benzyl-5-chloro-quinoline

合成工艺路线路线简述

    📜4-羟基-5-氯喹啉置于三氯氧磷体系中,化学反应生成4,5-二氯喹啉
    参考文献:Andersag,Chemische Berichte,1948,Vol. 81,P. 499,505
    标题:Andersag,Chemische Berichte,1948,Vol. 81,P. 499,505

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    专利信息


    专利号:WO-2013138200-A1
    优先权日:2012-03-13
    标 题 :Green chemistry synthesis of the malaria drug amodiaquine and analogs thereof
    发明人：FORTUNAK JOSEPH MARIAN; KULKARNI AMOL ANANT; KING CHRISTOPHER
    权利人:UNIV HOWARD
    摘要:Methods are provided for a green chemistry one-pot synthesis of amodiaquine and amodiaquine analogs. The methods have a lower environmental impact, lower investment cost, reduced amounts of byproducts and impurities, and a shorter synthesis time, compared to current conventional synthesis methods. The methods reduce the total number of steps in the synthesis from four to five down to two, thereby simplifying production; and allow a reduced number of solvents and reagents to be used in production, thereby reducing the waste generated in the synthesis. The methods can reduce the waste to about 3-5 kilograms of waste generated per kilogram of product produced; and surprisingly improve the overall yield from 60-65% to greater than 90% as compared to the current conventional synthesis methods for amodiaquine and its analogs.

    专利号:CN-114292232-A
    优先权日:2022-01-26
    标题:A kind of synthesis and purification method of 4,7-dichloroquinoline

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    主要参考文献

    参考标题: Green Chemistry Synthesis Of The Malaria Drug Amodiaquine And Analogs Thereof Synthèse De Chimie Verte Du Médicament Contre Le Paludisme, L'Amodiaquine Et Ses Analogues
    摘要:Methods Are Provided For A Green Chemistry One-Pot Synthesis Of Amodiaquine And Amodiaquine Analogs. The Methods Have A Lower Environmental Impact, Lower Investment Cost, Reduced Amounts Of Byproducts And Impurities, And A Shorter Synthesis Time, Compared To Current Conventional Synthesis Methods. The Methods Reduce The Total Number Of Steps In The Synthesis From Four To Five Down To Two, Thereby Simplifying Production; And Allow A Reduced Number Of Solvents And Reagents To Be Used In Production, Thereby Reducing The Waste Generated In The Synthesis. The Methods Can Reduce The Waste To About 3-5 Kilograms Of Waste Generated Per Kilogram Of Product Produced; And Surprisingly Improve The Overall Yield From 60-65% To Greater Than 90% As Compared To The Current Conventional Synthesis Methods For Amodiaquine And Its Analogs.

    合成参考文献


    参考文献:10.1016/j.chroma.2006.09.066
    摘要:Lindegårdh N, Giorgi F, Galletti B, Di Mattia M, Quaglia M, Carnevale D, White NJ, Mazzanti A, Day NP. Identification of an isomer impurity in piperaquine drug substance. J Chromatogr A. 2006 Dec 01;1135(2):166–9. doi: 10.1016/j.chroma.2006.09.066.
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