CAS: 20702-77-6; 1-(4-(((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(Hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-2-yl)Oxy)-2,6-Dihydroxyphenyl)-3-(3-Hydroxy-4-Methoxyphenyl)Propan-1-One

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在 盐酸体系中,用 水 用作溶剂,以96.8%的收率获得新橙皮甙二氢查尔酮
参考文献:一种新橙皮苷二氢查尔酮的制备方法
标题:一种新橙皮苷二氢查尔酮的制备方法
摘要:一种新橙皮苷二氢查尔酮的制备方法,包括以下步骤:(1)羰基保护:将新橙皮苷溶于有机溶剂或有机溶剂水溶液中,加入原甲酸三甲酯或原甲酸三乙酯以及缩酮催化剂进行缩酮反应,减压浓缩,冷却析晶,过滤,干燥,得化合物ⅰ;(2)水解反应:将化合物ⅰ溶于碱水溶液中,得化合物ⅱ的碱水溶液;(3)加氢反应:加入加氢催化剂,通入氮气保护,再通入氢气进行加氢反应,过滤,得化合物ⅲ的碱水溶液;(4)酸化析晶:调节ph值,冷却析晶,过滤,干燥,得新橙皮苷二氢查尔酮.按照本发明方法所得新橙皮苷二氢查尔酮的收率可高达97.2%,纯度可高达98.5%;本发明方法简单,反应条件温和,成本低,部分催化剂可回收,适宜于工业化生产.

专利信息

专利号:US-11773128-B2
优先权日:2019-03-28
标题 :Electrocatalytic synthesis of dihydrochalcones
发明人：REDKO MIKHAIL; SAFFRON CHRISTOPHER M; JACKSON JAMES E
权利人:UNIV MICHIGAN STATE
摘要:The disclosure relates to methods of forming a dihydrochalcone using electrocatalytic dehydrogenation. In particular, the disclosure relates to methods of forming a dihydrochalcone electrocatalytically hydrogenating (ECH) a reactant compound over a catalytic cathode in a reaction medium having a non-alkaline pH value, thereby forming a dihydrochalcone product; wherein the reactant compound has a structure according to Formula (I). The method can be used to prepare dihydrochalcone sweeteners, such as, for example, naringin dihydrochalcone and neohesperidin dihydrochalcone.

专利号:WO-2020198578-A1
优先权日:2019-03-28
标 题:Electrocatalytic synthesis of dihydrochalcones

专利号:US-2022089630-A1
优先权日:2019-03-28
标 题 :Electrocatalytic synthesis of dihydrochalcones