CAS: 19647-71-3; (S)-Benzyl (1-((4-Nitrophenyl)Amino)-1-Oxo-3-Phenylpropan-2-yl)Carbamate

上下游产品

N-Cbz-L-Phe N,N'-bis(4-nitrophenyl)phospheneimidous amide Cbz-D-Phe 4-nitro-anilineL-phenylalanine-p-nitroanilide H-Phe-pNA*HBr N-Cbz-L-Phe 4-nitro-aniline

📜N-苄氧羰基-L-苯丙氨酸,N,N'-Bis(4-Nitrophenyl)Phospheneimidous Amide置于吡啶体系中,化学反应 1.5H,以91%的收率获得n-Cbz-L-苯丙氨酸
参考文献:Reinvestigation Of The Phosphazo Method And Synthesis Ofn-(T-Butoxycarbonyl)-L-Argininep-Nitroanilide And A Chromogenic Enzyme Substrate For The Factor Xa
标题:Reinvestigation Of The Phosphazo Method And Synthesis Ofn-(T-Butoxycarbonyl)-L-Argininep-Nitroanilide And A Chromogenic Enzyme Substrate For The Factor Xa
摘要:为将磷氮法应用于合成对硝基苯胺(Pna)的叔丁氧羰基(Boc)和苄氧羰基(Z)氨基酸,重新研究了反应条件.
Doi:10.1246/bcsj.64.1422

专利信息

专利号:WO-2009080631-A2
优先权日:2007-12-21
标 题 :Chemo-enzymatic synthesis of a c-terminal aryl amide of an amino acid or peptide
发明人：QUAEDFLIEG PETER JAN LEONARD MARIO; NUIJENS TIMO; CUSAN CLAUDIA
权利人:DSM IP ASSETS BV; QUAEDFLIEG PETER JAN LEONARD MARIO; NUIJENS TIMO; CUSAN CLAUDIA
摘要:The present invention relates to a method for preparing an aryl amide, comprising reacting an aryl amine with a compound selected from N-protected amino acids and optionally N-protected peptides in the presence of a hydrolytic enzyme. The invention further relates to the use of a compound obtained in a method according to the invention in the manufacture of a diagnostic. In addition the invention relates to the use of a compound obtained in a method according to the invention as a substrate for a proteolytic enzyme.