CAS: 182163-96-8; 3,4,5-Trimethoxyphenylboronic Acid

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CAS号2675-79-8 5-溴-1,2,3-三甲氧基苯 | CAS号121-43-7 硼酸三甲酯 | CAS号133095-91-7 3,4,5-三甲氧基苯基溴化镁 | CAS号25245-29-8 5-碘-1,2,3-三甲氧基苯 | CAS号24313-88-0 3,4,5-三甲氧基苯胺 | CAS号1016971-56-4 2,4,6-tris(3,4,... | CAS号1016971-65-5 2,4-bis(4-metho... | CAS号1016971-69-9 2,4-bis(3,5-di-... | CAS号487-11-6 5-烯丙基-1,2,3-三甲氧基苯 | CAS号1885-35-4 3,4,5-三甲氧基苯甲腈 | CAS号1016971-56-4 2,4,6-tris(3,4,... | CAS号34907-38-5 2,4,6-TRIS(3,5-... | CAS号1528-74-1 4,4-二硝基联苯 | CAS号1146731-51-2 N-B°C-2-(4-nitr... | CAS号56772-00-0 3,3',4,4',5,5'-... | CAS号65684-98-2 2-phenyl-5-(3,4...

1-溴-3,4,5-三甲氧基苯置于正丁基锂,硼酸三甲酯体系中,用 四氢呋喃,正己烷 用作溶剂,化学反应 19.0H,以64%的收率获得3,4,5-三甲氧基苯硼酸
参考文献:四苯乙烯衍生柱状液晶及其氧化光环化
标题:四苯乙烯衍生柱状液晶及其氧化光环化
摘要:描述了通过 Mcmurry 反应和 Suzuki 偶联作为关键步骤合成带有醚,联苯和 4-氰基联苯部分的新型四苯基乙烯 9A-F,13 和 18A,B.通过差示扫描量热法 (Dsc),光学偏光显微镜和 X 射线衍射研究了这些化合物的介晶性质.链长为 C8 或 C9 的醚取代衍生物 9A,B 是非介晶的.具有较长烷基链的化合物 9C-F 显示六方柱状中间相.虽然氰基联苯衍生物 13 是非介晶的,但相应的联苯系统 18A,B 分别具有癸氧基和十二烷氧基链,形成六方柱状中间相.研究了化合物 1F,9C,13 和 18A 的氧化光环化.在碘四苯乙烯 1F 存在下照射后,9C得到相应的菲22A,B.22A,B 的介晶性质强烈依赖于取代基.而醚 22A 仅显示各向同性熔化,而发现酯 22B 为六方柱状中间相.(© Wiley-Vch Verlag Gmbh & Co. Kgaa,69451 Weinheim
Doi:10.1002/ejoc.200300118

专利信息

专利号:US-9573873-B2
优先权日:2014-06-03
标题:Catalytic method for dibenzocycloheptane synthesis and allocolchicinoid synthesis
发明人：GREEN JAMES; MEHDI MARIAM; DJURDJEVIC SINISA
权利人:UNIV OF WINDSOR
摘要:In a non-limiting embodiment, there is provided a compound of formula (I), which may permit for a method or use in treating or preventing a cancer, such as pancreatic cancer or leukemia. In one embodiment, there is also provide a method of preparing a compound of formula (Ia), the method including conducting a cyclization reaction of a compound of formula (III) to obtain a compound of formula (IV), wherein conducting the cyclization reaction comprises conducting a Michael reaction in the presence of a Lewis acid.

专利号:WO-2004087679-A1
优先权日:2003-04-01
标 题 :2, 4, 6-trisubstituted pyrimidine derivatives useful for the treatment of neoplastic and autoimmune diseases
发明人：OBRECHT DANIEL; ERMERT PHILIPP; LUTHER ANATOL; EBERLE MARTIN; BACHMANN FELIX
权利人:APONETICS AG; OBRECHT DANIEL; ERMERT PHILIPP; LUTHER ANATOL; EBERLE MARTIN; BACHMANN FELIX
摘要:The invention relates to substituted pyrimidines of formula (I) wherein V represents a bond or CR6R7, W represents a bond, NR8 or oxygen, X represents sulfur, or nitrogen substituted by hydrogen or R5, Y represents -CH2-, -CH2CH2-, -CO- or -CS-, R1 represents unsubstituted or substituted aryl or heteroaryl, and the substituents R2, R3, R4, R5, R6, R7 and R8 have the meanings given in the specification. These compounds are selectively inducing apoptosis in cancer cells and can be used for the treatment of neoplastic and autoimmune diseases. The invention relates also to methods of synthesis of such compounds, to their use as medicaments, to pharmaceutical compositions containing same, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

专利号:US-9611281-B2
优先权日:2013-12-05
标题:BODIPY derivatives and methods of synthesis and use thereof
发明人：YOU YOUNGJAE; AWUAH SAMUEL; WATLEY RYAN
权利人:UNIV OKLAHOMA
摘要:Derivatives of BODIPY (boron dipyrromethene difluoride) and their synthesis and use are disclosed.

专利号:US-7572778-B2
优先权日:2003-07-18
标题 :Fluorocombretastatin and derivatives thereof
发明人：GIANNINI GIUSEPPE; ALLOATTI DOMENICO; MARCELLINI MARCELLA; MARZI MAURO; RICCIONI TERESA; TINTI MARIA ORNELLA
权利人:SIGMA TAU IND FARMACEUTI
摘要:The present invention is related to new derivatives of Combretastatin, of Formula n nobtained by total synthesis. The strategy developed for each of the compounds is to i) replace a halogen (i.e. fluorine atom) to hydrogen on olefinic bound; ii) replace an aromatic ring in a natural product with an amino-aromatic ring. Said compounds recognize and bind the tubulin site: are useful for treating pathological states which arise from or are exacerbated by cell proliferation—as anticancer and/or antiangiogenic activity, in a mammal—to pharmaceutical compositions comprising these compounds.

专利号:US-11306103-B2
优先权日:2017-11-30
标题:Thieno[3,2-b]pyridine-5(4H)-one derivative compound, preparation method thereof and use thereof
发明人：LEE JONG SEOK; SUNG DAN BI; MUN BO HYUN; LEE HYI SEUNG; LEE YEON JU; LEE JI HOON; SHIN HEE JAE; PARK SOL
权利人:KOREA INST OCEAN SCI & TECH
摘要:The present invention relates to a novel thieno[3,2-b]pyridine-5(4H)-one derivative compound, a preparation method thereof, and a use thereof. The novel thieno[3,2-b]pyridine-5(4H)-one derivative compound according to the present invention is synthesized via an aza-[3+3] cyclization addition reaction using BOP, wherein the compound is obtained by synthesizing a 4-arylthiophen-3-amine in which aryl groups such as 4-piperidyl-C6H4, 4-pyrrolidyl-C6H4, 4-MeOC6H4, 3,4,5-(MeO)3C6H4, C6H5, 4-C6H5C6H4, and 4-F3COC6H4 are introduced via a synthesis process by a bromination reaction, a hydrolysis reaction, a decarboxylation reaction, and a Suzuki coupling reaction of methyl 3-aminothiophene carboxylate, and by synthesizing 4-arylthiophen-3-amine and mono-methyl fumarate via a formal aza-[3+3] cyclization addition reaction using BOP and conjugation. Accordingly, novel thieno[3,2-b]pyridine-5(4H)-one derivative compounds according to the present invention have fluorescence properties with a wide range of emission wavelengths and thus may be utilized in various industrial fields such as physics, chemistry, and biomedical research.

专利号:US-2015158888-A1
优先权日:2013-12-05
标题:BODIPY Derivatives and Methods of Synthesis and Use Thereof