CAS: 136779-26-5; (2S,5S)-1-[2-[(2S,5S)-2,5-Dimethylphospholan-1-Yl]Ethyl]-2,5-Dimethylphospholane

上下游产品

CAS号17299-07-9 (2R,5R)-2,5-己二醇 | CAS号129705-31-3 (2R,5R)-hexane-... | CAS号5518-62-7 1,2-双(膦酰)乙烷 | CAS号136779-29-8 (4R,7R)-4,7-dim... | CAS号6315-52-2 亚乙基二(p-甲苯磺酸盐) | CAS号129705-29-9 (2S,5S)-2,5-dim...

📜(1R,4R)-4-Methanesulfonyloxy-1-Methylpentyl Methanesulfonate置于lithium体系中,用 四氢呋喃 用作溶剂,化学反应 28.0H,反应生成(-)-1,2-双((2S,5S)-2,5-二甲基膦)乙烷
参考文献:新的手性膦酸酯;合成,表征及其在不对称氢化反应中的用途
标题:新的手性膦酸酯;合成,表征及其在不对称氢化反应中的用途
摘要:我们描述了对映体纯的反式-2,5-二取代-1-苯基膦酸酯的实际合成,然后将其用于制备一系列新的c 2对称双-和c 3对称三(膦)配体.概述了用于膦合成的重要手性1,4-二醇中间体的通用三步路线.制备了带有新的膦配体的铑配合物,并显示出它们可作为对各种不饱和底物进行对映选择性氢化的有效催化剂前体.
Doi:10.1016/s0957-4166(00)86109-1

专利信息

专利号:US-6891059-B2
优先权日:2000-01-27
标题:Asymmetric synthesis of pregabalin
发明人：BURK MARK JOSEPH; GOEL OM PRAKASH; HOEKSTRA MARVIN SIMON; MICH THOMAS FREDERICK; MULHERN THOMAS; RAMSDEN JAMES A
权利人:WARNER LAMBERT CO
摘要:This invention provides a method of making (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) or a salt thereof via an asymmetric hydrogenation synthesis. Pregabalin is useful for the treatment and prevention of seizure disorders, pain, and psychotic disorders. The invention also provides intermediates useful in the production of pregabalin.

专利号:US-9403766-B2
优先权日:2008-01-17
标 题:Intermediates for producing NEP inhibitors or prodrugs thereof
发明人：HOOK DAVID; RISS BERNARD; KAUFMANN DANIEL; NAPP MATTHIAS; BAPPERT ERHARD; POLLEUX PHILIPPE; MEDLOCK JONATHAN; ZANOTTI-GEROSA ANTONIO
权利人:HOOK DAVID; RISS BERNARD; KAUFMANN DANIEL; NAPP MATTHIAS; BAPPERT ERHARD; POLLEUX PHILIPPE; MEDLOCK JONATHAN; ZANOTTI-GEROSA ANTONIO; NOVARTIS AG
摘要:The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, n nwherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.

专利号:JP-2009073841-A
优先权日:2000-01-27
标 题 :Asymmetric synthesis of pregabalin

专利号:HU-P0204307-A2
优先权日:2000-01-27
标 题 :Asymmetric synthesis of pregabalin

专利号:TW-I288128-B
优先权日:2000-01-27
标 题 :Asymmetric synthesis of pregabalin

专利号:JP-2003520841-A
优先权日:2000-01-27
标题:Asymmetric synthesis of pregabalin