CAS: 122-73-6; Isoamyl Benzyl Ether

该化合物是一种有机化合物,以[(3-甲基-丁氧)甲基]组取代苯环,这种结构具有独特的溶性和反应性特征,使其作为有机合成和特殊化学应用的中间体具有价值.其醚联系和分支烷基链提高了与非极溶剂的兼容性,而芳香环则为进一步的功能化提供了稳定性.该化合物对于发展香气,农用化学品和制药中间体特别有用,需要控制性再活性和量度.适当的处理由于其潜在的易燃性和避免长期接触的必要性而必不可少.

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1-chloromethoxy-3-methyl-butane i-Amyl alcohol benzyl chloride sodium isopentoxideDiphenylmethane isoamyl benzoate benzaldehyde isopentyl nitrite

合成工艺路线路线简述

    📜以 四氢呋喃,甲苯 用作溶剂,化学反应 6.0H,以46 Mg的收率获得[(3-甲基丁氧基)甲基]苯
    参考文献:通过钛环丁烷的质子分解进行位点特异性烯烃氢甲基化
    标题:通过钛环丁烷的质子分解进行位点特异性烯烃氢甲基化
    摘要:甲基在生物活性分子中普遍存在.因此,将这种烷基片段引入多官能结构的新策略引起了人们的极大兴趣.考虑到这一目标,报告了一种烯烃马尔可夫尼科夫氢甲基化的直接方法.该方法利用了cp 2 Ti(μ-Cl)(μ-Ch 2 )Alme 2 (Tebbe试剂)中的钛亚甲基与未活化的烯烃之间的简并复分解反应.所得环丁烷钛的原位质子解作用以化学,区域和位点选择性方式实现氢甲基化.该方法的广泛实用性在一系列含有侧醇,醚,酰胺,氨基甲酸酯和碱性胺的单取代和二取代烯烃中得到了证明.
    Doi:10.1002/anie.202103278

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    专利信息


    专利号:US-9809566-B2
    优先权日:2012-09-06
    标题:Organocatalytic process for asymmetric synthesis of decanolides
    发明人:RAWAT VARUN; DEY SOUMEN; SHELKE ANIL MARUTI; SURYAVANSHI GURUNATH MALLAPPA; SUDALAI ARUMUGAM
    权利人:COUNCIL SCIENT IND RES
    摘要:The present invention discloses organocatalytic process for asymmetric synthesis of highly enantioselective decanolide compounds in high yield with >99% ee. Further, the present invention disclose cost effective, improved organocatalytic process for asymmetric synthesis of highly enantioselective decanolides compounds from non-chiral, cheap, easily available raw materials.

    专利号:US-10336784-B2
    优先权日:2016-03-08
    标 题 :Methods for modular synthesis of N-glycans and arrays thereof
    发明人:WONG CHI-HUEY; WU CHUNG-YI; SHIVATARE SACHIN S
    权利人:ACADEMIA SINICA
    摘要:The present disclosure relates to novel modular methods for generating a diversity of N-glycans of high mannose, hybrid and complex types. The present disclosure also relates to exemplary arrays of the synthesized N-glycans spotted onto aluminium oxide coated slides. These arrays can be used to detect and analyze binding interactions between the synthesized N-glycans and glycan binding molecules, such as HIV-1 neutralizing antibodies. The present disclosure also relates to methods for identifying agents that bind to various types of molecules on the arrays and to defining the structural elements of the molecules on the arrays that bind to those agents. The arrays and methods provided herein may be used for general epitope identification, drug discovery and as analytical tools. The present disclosure also provides useful glycans and epitope determinants that are useful in detecting, diagnosing, recurrence monitoring and preventing pathological diseases such as HIV.

    专利号:BR-112018073219-B1
    优先权日:2016-07-21
    标 题 :COMPOUND OF FORMULA I, PHARMACEUTICAL COMPOSITION, PROCESS FOR THE SYNTHESIS OF THESE COMPOUNDS AND USE OF THE SAME

    专利号:CA-3109107-A1
    优先权日:2018-08-13
    标题 :Preparation of intermediate useful for synthesis of a diphenylmethane derivative for use as a sglt inhibitor

    专利号:JP-H07508015-A
    优先权日:1992-06-30
    标题 :Synthesis of 1,4,7-triazacyclononane derivatives

    专利号:RU-2017131026-A
    优先权日:2015-03-13
    标 题:METHOD OF SYNTHESIS OF NEW COMPOUNDS OBTAINED FROM 3-HYDROXYCLICENTO ACOXY ACID

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1007/978-94-011-3064-6_1
    摘要:Poucher WA. A. 1991. In: Poucher’s Perfumes, Cosmetics and Soaps — Volume 1. : Springer Netherlands; 1991.
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