CAS: 1161497-23-9; 3-Bromo-4-Fluoroanisole

该化合物是一种卤化芳香化合物,其成分为溴,氟和甲基氧代金体,在苯环上具有溴,氟和甲氧替代成分.其独特的替代模式使其在有机合成中成为有价值的中间体,特别是在制药和农用化学应用中.电镀(溴,氟)和电镀(methoxy)组的存在增强了其在交叉反应中的再活动性,如铃木或Buchwald-Hartwig 组合,能够进行精确的结构修改.该化合物的稳定性和定义明确的再活动特征有助于其在建设复杂的分子结构中使用.通常在标准的实验室条件下处理,但应该遵守对卤化化合物的适当防范措施.

英文名称3-Bromo-4-Fluoroanisole
中文名称3-溴-4-氟苯甲醚
IUPAC名称2-bromo-1-fluoro-4-methoxybenzene
其它别名2-溴-1-氟-4-甲氧基苯; Benzene, 2-Bromo-1-Fluoro-4-Methoxy-
CAS编号1161497-23-9
MFCD编号:MFCD13185359
EINECS号:843-351-2
分子式:C7H6BrFO
分子量:205.02
产品CID: 206294
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: LYIGJBQYDRJPIR-UHFFFAOYSA-N
InChI=1S/C7H6BrFO/c1-10-5-2-3-7(9)6(8)4-5/h2-4H,1H3…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数1.0

相似化合物

295376-21-5 943831-06-9 1507082-29-2

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
严重眼刺激类别2
警示词Warning(警告)
危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

欧盟法规

C&L通报

上下游产品

3-溴-4-氟苯酚 3-Bromo-4-Fluorophenol 27407-11-0

合成工艺路线路线简述

2-氟-5-甲氧基苯硼酸置于copper(Ll) Bromide体系中,用甲醇,水用作溶剂,以76%的收率获得3-溴-4-氟苯甲醚
参考文献: Pyrimidine Amide Compounds[fr] Composés Pyrimidine Amide
标题: Pyrimidine Amide Compounds[fr] Composés Pyrimidine Amide
摘要:本文提供的化合物为式(I)的化合物及其药学上可接受的盐,其中取代基如规范中所披露的那样.这些化合物及含有它们的药物组合物对于治疗炎症性疾病和紊乱,例如哮喘和慢性阻塞性肺病(copd)等,具有实用性.

海关参考信息

2905110000-甲醇
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物
2918290000-其他含酚基羧酸
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-7884125-B2
优先权日:2008-04-30
标题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-2009275616-A1
优先权日:2008-04-30
标题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues

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优先权日:2020-03-04
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优先权日:2020-03-04
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优先权日:2020-03-04
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