专利号:US-7601318-B2 优先权日:2000-09-26 标 题:Method for synthesis of carbon-coated redox materials with controlled size 发明人:ARMAND MICHEL; GAUTHIER MICHEL; MAGNAN JEAN-FRANCOIS; RAVET NATHALIE 权利人:HYDRO QUEBEC; CENTRE NAT RECH SCIENT; UNIV MONTREAL 摘要:A method for the synthesis of compounds of the formula C—Li x M 1−y M′ y (XO 4 ) n , where C represents carbon cross-linked with the compound Li x M 1−y M′ y (XO 4 ) n , in which x, y and n are numbers such as 0≦x≦2, 0≦y≦0.6, and 1≦n≦1.5, M is a transition metal or a mixture of transition metals from the first period of the periodic table, M′ is an element with fixed valency selected among Mg 2+ , Ca 2+ , Al 3+ , Zn 2+ or a combination of these same elements and X is chosen among S, P and Si, by bringing into equilibrium, in the required proportions, the mixture of precursors, with a gaseous atmosphere, the synthesis taking place by reaction and bringing into equilibrium, in the required proportions, the mixture of the precursors, the procedure comprising at least one pyrolysis step of the carbon source compound in such a way as to obtain a compound in which the electronic conductivity measured on a sample of powder compressed at a pressure of 3750 Kg·cm −2 is greater than 10 −8 S·cm −1 . The materials obtained have excellent electrical conductivity, as well a very improved chemical activity.
专利号:US-2023174567-A1 优先权日:2020-05-22 标题:Synthesis of fluorinated nucleotides 发明人:ARMIGER TRAVIS; BELYK KEVIN M; BENKOVICS TAMAS; CHUNG CHEOL K; JI CHEN YINING; JOHNSON HEATHER CLAIRE; KLAPARS ARTIS; LIU ZHIJIAN; LIU ZHUQING; MOORE JEFFREY C; NEEL ANDREW J; PENG FENG; RUMMELT STEPHAN M; SALEHI MARZUARANI NASTARAN; SHERRY BENJAMIN D; SONG ZHIGUO JAKE; TURNBULL BEN WILLIAM HULME; WANG LU; XU FENG 权利人:MERCK SHARP & DOHME LLC 摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3′-fluoro-thio-guanosine monophosphate or 3′-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. (I)
专利号:US-6528642-B1 优先权日:1997-08-29 标题:Mono-and di-derivatives of cyclodextrins, synthesis thereof and purification and use thereof in support 发明人:DUVAL RAPHAEL; LEVEQUE HUBERT 权利人:INST FRANCAIS DU PETROLE; CHIRALSEP SARL 摘要:Mono- and di-derivatives of cyclodextrins are completely defined, also a method for their synthesis and purification, functionalised cyclodextrins obtained from these derivatives, and the synthesis of supports comprising these cyclodextrin derivatives. Use of the supports for the preparation or separation of enantiomers, for asymmetric synthesis, for catalysis, for the preparation or separation of geometrical isomers or positional isomers, or for the preparation or separation of organic molecules with a hydrophobic nature is also described.
专利号:US-2008112874-A1 优先权日:2006-08-31 标 题:Method for producing calcium phosphate powders using an auto-ignition combustion synthesis reaction 发明人:BURKES DOUGLAS E; MOORE JOHN J; AYERS REED A 权利人:BURKES DOUGLAS E; MOORE JOHN J; AYERS REED A 摘要:A method for making high purity, multiphasic calcium phosphate powders using an Auto-Ignition Combustion Synthesis (AICS) reaction of a calcium salt, a phosphate salt and a fuel is provided. In the method provided, energy released from the AICS reaction between the calcium salt, phosphate salt and fuel ignites at temperatures much lower than the actual phase transformation temperatures and reaches a high temperature rapidly enough for synthesis of the desired product to occur, without the requirement for coprecipitation, an external heat source for calcination and/or additional steps for removing undesired precursors from the desired final product.
专利号:US-12017206-B2 优先权日:2021-09-30 标 题 :Preparation method of Cu—Pd—CeO2/γ—Al2O3@NP catalyst and synthesis method of benzopyrazine compounds 发明人:FENG FENG; LI XIAONIAN; GUO LINGLING; SUN YANXIA; LU CHUNSHAN; ZHANG QUNFENG; Jin Jiatong; XU XIAOLIANG 权利人:UNIV ZHEJIANG TECHNOLOGY 摘要:A preparation method of Cu—Pd—CeO 2 /γ-Al 2 O 3 @NP catalyst and a synthesis method of benzopyrazine compounds. The preparation method of the Cu—Pd—CeO 2 /γ-Al 2 O 3 @NP catalyst comprises the following steps: (1) preparing a CeO 2 /γ-Al 2 O 3 carrier; (2) preparing a CeO 2 /γ-Al 2 O 3 @NP carrier; (3) preparing the Cu—Pd—CeO 2 /γ-Al 2 O 3 @NP catalyst by impregnation method. A one-pot method for synthesizing benzopyrazine compounds of formula (III) includes using an o-nitroaniline compound of formula (I) and an aliphatic diol compound of formula (II) as raw materials, carrying out the one-pot synthesis of the benzopyrazine compound of formula (III) under solvent-free condition and under the combined action of the Cu—Pd—CeO 2 /γ-Al 2 O 3 @NP catalyst prepared by the method and an alkali. The Cu—Pd—CeO 2 /γ-Al 2 O 3 @NP catalyst increases the number of basic sites by doping N and P, and meanwhile loads CeO 2 to assist in the extraction of protons, thereby improving the dehydrogenation activity and product selectivity.
专利号:US-9376460-B2 优先权日:2012-08-05 标题:Method of polyphosphate synthesis 发明人:CHMIELEWSKI MARCIN KRZYSZTOF; ROMANOWSKA JOANNA 权利人:INST CHEMII BIOORG POLSKIEJ AKADEMII NAUK 摘要:The subject of the invention is a new method of the synthesis of polyphosphate analogs, such as nucleosides, oligonucleotides, carbohydrates, peptides and proteins, which are of biological importance and are used in organic chemistry, molecular biology and biotechnology. Polyphosphate analogs, including in particular nucleoside 5′-triphosphates, display high biological activity and are responsible for the provision and storage of energy in live organisms. The method relates to the synthesis of organic polyphosphates of general formula (1), where n has a value of 0 to 2, while X stands for an organic radical, in particular nucleoside, oligonucleotide, peptide-carbohydrate or a protein radical.
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