CAS: 1009-67-2; 2-Methyl-3-Phenylpropanoic Acid

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14367-54-5 7384-80-7 1012-15-3

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📜Methyl 2-Methyl-3-Phenylpropionate置于氢氧化钾体系中,用 乙醇,水 用作溶剂,化学反应 8.0H,以100%的收率获得2-苄基丙酸
参考文献:微生物对α-取代的羧酸的脱硝作用:底物特异性和机理研究.
标题:微生物对α-取代的羧酸的脱硝作用:底物特异性和机理研究.
摘要:报道了一种用于制备旋光的α-取代的羧酸的新的酶促方法.这项技术称为脱硝反应,它为我们提供了从外消旋混合物开始,理论上以100%的收率获得对映体纯化合物的途径.这意示外消旋体的合成几乎与旋光化合物的合成相同,并且该概念与不对称合成中通常被接受的概念完全不同.使用不断增长的诺卡氏夜蛾诺卡氏菌jcm3208的细胞系统,可以使2-芳基-和2-芳基氧基丙酸的外消旋物顺利脱硫,并以高化学收率(> 50%)回收富含(R)-形式的产物.此外,使用旋光性起始化合物和氘代衍生物以及抑制剂,
Doi:10.1021/jo034253X

专利信息

专利号:US-2003092064-A1
优先权日:2001-04-05
标题 :System for the synthesis of spatially separated libraries of compounds and methods for the use thereof
发明人：READER JOHN C
权利人:MILLENNIUM PHARM INC
摘要:Featured is an apparatus useful for preparing combinatorial libraries of compounds in a parallel fashion so that the individual compounds of the library are spatially separate and the position of each compound of the library in the apparatus is known. Moreover, the apparatus is useful for the preparation of combinatorial libraries of compounds where the library is constructed from three or more building blocks, e.g., three, four, five, six or seven building blocks, resulting in a three, four, five, six or seven dimensional combinatorial library. Also featured are related methods for the preparation of three, four, five, six or seven dimensional combinatorial libraries of compounds using the apparatus of the present invention.

专利号:US-6509484-B2
优先权日:1993-02-05
标 题:Synthesis of taxol, taxol analogs and their intermediates with variable a-ring side chain structures and compositions thereof
发明人：SWINDELL CHARLES S; KRAUSS NANCY
权利人:NAPRO BIOTHERAPEUTICS INC
摘要:The present invention relates to chemical compounds that are useful in the production of taxanes. The chemical compounds according to the present invention have a generalized formula: n wherein R 1 is + NH 3 X − where X is deprotonated organic acid such as deprotonated trifluoroacetic acid, and wherein R 2 may be acetyl or hydrogen, and P 1 may be hydrogen or a hydroxyl protecting group, such as benzyloxymethyl.

专利号:US-8670941-B2
优先权日:2006-08-18
标题:Methods of determining levels of free amino acids and dipeptides and diagnosing Alzheimer's disease
发明人：FONTEH ALFRED N; HARRINGTON MICHAEL G
权利人:FONTEH ALFRED N; HARRINGTON MICHAEL G; HUNTINGTON MEDICAL RES INST
摘要:Provided herein are methods of diagnosing Alzheimer's disease (“ADâ€?) based on characteristic changes of the levels of certain free amino acids or dipeptides (collectively termed as “AD diagnosis markersâ€?) in the body fluid sample of an individual, carnosine synthesis activities in the plasma, and dopamine synthesis activities in the plasma. Also provided are methods of simultaneously determining the levels of at least two free amino acids or dipeptides in the biological fluid sample of an individual.

专利号:US-7390801-B2
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-2005124683-A1
优先权日:2003-09-17
标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：ALEGRIA LARRY A; CANAN-KOCH STACIE S; DRESS KLAUS R; HUANG BUWEN; KUMPF ROBERT A; LEWIS KATHLEEN K; MATTHEWS JEAN J; SAKATA SYLVIE K; VIRGIL SCOTT C
权利人:AGOURON PHARMA
摘要:The present invention relates to a series of chemical compounds useful as Human Immunodeficiency Virus (HIV) protease inhibitors and to the use of such compounds as antiviral agents. The invention further relates to pharmaceutical compositions containing such antiviral agents, and their uses and materials for their synthesis

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.