CAS: 98027-81-7; 2,6-Dibromo-4-Nitropyridine 1-Oxide

该化合物是一种卤化硝基丙烯衍生物,在合成有机化学方面非常有用.其主要优势包括它作为制药,农用化学和特种材料的多用途中间体的作用.溴和硝基化合物的存在增强了其反应性,促进了选择性功能化和交叉反应.该化合物在标准条件下的稳定性确保了可靠的处理和储存.其电子缺乏的丙烯酸核心使得其在核分裂替代和金属催化转化中特别有用.研究人员认为这一复合体具有将溴和硝基功能引入目标分子的能力,从而能够有效地合成复杂的循环结构.

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CAS号25373-69-7 2,6-二溴吡啶N-氧化物 | CAS号626-05-1 2,6-二溴吡啶 | CAS号7664-93-9 硫酸 | CAS号7697-37-2 硝酸 | CAS号329974-09-6 4-溴-2,6-二氨基吡啶 | CAS号39771-34-1 2,6-二溴-4-氨基吡啶 | CAS号205052-97-7 6-BROMO-4-NITRO... | CAS号193944-66-0 4'-氨基-2,2':6',2... | CAS号213674-46-5 4'-硝基-2,2':6',2... | CAS号2408-70-0 2,4,6-三溴吡啶 | CAS号337917-94-9 2,6-dibromo-4-p... | CAS号170875-37-3 2,4,6-三溴吡啶氮氧化物 | CAS号170875-40-8 2-acetoxy-4,6-d... | CAS号175422-04-5 2,6-二溴-4-硝基吡啶

合成工艺路线路线简述

  • 626-05-1 = 98027-81-7 + 175422-04-5
    反应条件:1.1R:F3Cco2H,R:H2O2,Rt; Overnight,Reflux1.2R:H2O1.3R:Nahco3,S:H2O,Neutralized2.1R:H2So4,R:Hno3,0°C; Overnight,90°C
    标题:A Strong Hydride Donating,Acid Stable And Reusable 1,4-Dihydropyridine For Selective Aldimine And Aldehyde Reductions
    作者:By Hirao,Yasukazu Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:1671 卷标:20(8) 页码:1671-1679]

    25373-69-7 = 98027-81-7
    反应条件:1.1R:H2So4,R:Hno3,22 H,60°C; 60°C -> Rt1.2R:Nh4Cl,S:H2O,Cooled
    标题:A Mof Platform For Incorporation Of Complementary Organic Motifs For Co2 Binding
    作者:By Deria,Pravas Et Al
    参考文献:Chemical Communications (Cambridge 日期:1247 卷标:51(62) 页码:12478-12481]

    626-05-1 = 98027-81-7
    反应条件:1.1R:H2O2,S:H2O,S:F3Cco2H,80°C; 4 H,80°C2.1R:H2So4,R:Hno3,90°C; 2 H,90°C
    标题:Synthesis And Characterization Of Highly Stable And Efficient Star-Molecules
    作者:By Huang,Hai-Fang Et Al
    参考文献:Dyes And Pigments 日期:2013 卷标:96(3) 页码:705-713]

    626-05-1 = 98027-81-7
    反应条件:1.1R:H2O2,S:H2O,S:F3Cco2H,3 H,42°C; 42°C -> Rt1.2R:H2O,Rt -> -5°C1.3R:Disodium Carbonate,Neutralized2.1R:Hno3 no2,R:H2So4,S:H2O,Rt -> 90°C; 2 H,90°C; Cooled2.2R:H2O,Cooled
    标题:Preparation Of 2,6-Dibromo-4-Aminopyridine
    作者:By Niu,Qian-Qian Et Al
    参考文献:Fenzi Kexue Xuebao 日期:2006 卷标:22(6) 页码:401-404]

    626-05-1 = 98027-81-7 + 175422-04-5
    反应条件:1.1R:F3Cco2H,R:H2O2,S:H2O,Overnight,Reflux1.2R:H2O2.1R:H2So4,R:Hno3,0°C; 5 H,90°C
    标题:Interaction Of The Dihydropyridine/pyridinium Redox Pair Fixed Into A V-Shaped Conformation
    作者:By Hirao,Yasukazu Et Al
    参考文献:Heterocycles 日期:1345 卷标:98(10) 页码:1345-1353]

    626-05-1 = 98027-81-7
    反应条件:1.1R:F3Cco2H,R:H2O2,S:H2O,4 H,90°C; 90°C -> Rt1.2S:H2O,3 H,0°C1.3R:Disodium Carbonate,0°C,Neutralized2.1R:H2So4,Rt2.2R:H2So4,R:Hno3,Rt -> 80°C; 25 Min,80°C; 3.5 H,80°C; 80°C -> Rt2.3R:H2O,0°C
    标题:Access To 3-Deazaguanosine Building Blocks For Rna Solid-Phase Synthesis Involving Hartwig-Buchwald C-N Cross-Coupling
    作者:By Mairhofer,Elisabeth Et Al
    参考文献:Organic Letters 日期:3900 卷标:21(11) 页码:3900-3903]

    626-05-1 = 98027-81-7
    反应条件:1.1R:F3Cco2H,R:H2O2,R:O(C(=o)Cf3)2,S:H2O,80°C; 4 H,80°C2.1R:Hno3 no2,R:H2So4,90°C; 2 H,90°C
    标题:Synthesis Of Hyperbranched Polypyridine Via A Cross Coupling Approach As An N-Type π-Conjugated Polymer
    作者:By Koga,Takashi Et Al
    参考文献:Macromolecular Chemistry And Physics 日期:2017 卷标:218(22)]

    626-05-1 = 98027-81-7
    反应条件:1.1R:F3Cco2H,R:H2O22.1R:H2So4,R:Hno3
    标题:Process Development And Crystallization In Oiling-Out System Of A Novel Topical Antiandrogen
    作者:By Daver,Sebastien Et Al
    参考文献:Organic Process Research & Development 日期:2017 卷标:21(2) 页码:231-240]

    626-05-1 = 98027-81-7
    反应条件:1.1R:F3Cco2H,R:H2O2,S:H2O,Rt; 12 H,100°C2.1R:H2So4,R:Hno3,0°C; 12 H,60°C2.2R:Nahco3,S:H2O,0°C
    标题:Inhibition Of Cancer-Associated Mutant Isocitrate Dehydrogenases: Synthesis,Structure-Activity Relationship,And Selective Antitumor Activity
    作者:By Liu,Zhen Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:8307 卷标:57(20) 页码:8307-8318]

    626-05-1 = 98027-81-7
    反应条件:1.1R:H2Nc(=o)Nh2 h2O2,R:O(C(=o)Cf3)2,S:Ch2Cl2,Rt -> 5°C; 45 Min,5-7°C; 7°C -> Rt; 20 H,Rt; Rt -> 10°C1.2R:Na2So4,S:H2O,60 Min,10°C2.1R:H2So4,R:Hno3,Rt; Rt -> 79°C; 25 Min,79°C; 3.5 H,83-85°C; 85°C -> Rt
    标题:A Flexible Synthesis Of C-6 And N-1 Analogues Of A 4-Amino-1,3-Dihydroimidazo[4,5-C]Pyridin-2-One Core
    作者:By Hay,Duncan A. Et Al
    参考文献:Tetrahedron Letters 日期:5728 卷标:52(44) 页码:5728-5732]

    626-05-1 = 98027-81-7
    反应条件:1.1R:F3Cco2H,R:H2O2,S:H2O,1 H,35°C; 35°C -> Rt1.2R:Disodium Carbonate,S:H2O,Ph 92.1R:Hno3 no2,R:H2So4,S:H2O,Rt -> 80°C; 1 H,80°C
    标题:Process For Preparation Of 2,6-Bis[3-(Aminomethyl)-1-Pyrazolyl]Pyridine Derivative As Chelant Used In Homogeneous Time-Resolved Fluorescence Immunoassay
    作者:By Pan,Lihua Et Al
    参考文献:Faming Zhuanli Shenqing 日期:1012]

    626-05-1 = 98027-81-7
    反应条件:1.1R:F3Cco2H,R:H2O2,S:H2O,3 H,42°C; 42°C -> Rt1.2R:Disodium Carbonate,S:H2O,Basify2.1R:H2So4,R:Hno3,S:H2O,Rt -> 90°C; 2 H,90°C
    标题:Synthesis Of 2,6-Bis(3-Methyl-1H-Pyrazol-1-Yl)-4-Aminopyridine
    作者:By Li,Zhen Et Al
    参考文献:Huaxue Yanjiu 日期:2007 卷标:18(1) 页码:43-45]

    626-05-1 = 98027-81-7
    反应条件:1.1R:H2O2,S:H2O,S:F3Cco2H,1 H; 4 H,95-100°C2.1R:Hno3 no2,R:H2So4,20 H,60°C2.2R:Nh4Oh,S:H2O,Neutralized
    标题:The Development Of A Practical And Reliable Large-Scale Synthesis Of 2,6-Diamino-4-Bromopyridine
    作者:By Nettekoven,Matthias And Jenny,Christian
    参考文献:Organic Process Research & Development 日期:2003 卷标:7(1) 页码:38-43]

    626-05-1 = 98027-81-7
    反应条件:1.1R:F3Cco2H,R:H2O2,3 H,100°C2.1R:H2So4,R:Hno3,1.5 H,100°C
    标题:Influence Of The 5-Ht6 Receptor On Acetylcholine Release In The Cortex: Pharmacological Characterization Of 4-(2-Bromo-6-Pyrrolidin-1-Ylpyridine-4-Sulfonyl)Phenylamine,A Potent And Selective 5-Ht6 Receptor Antagonist
    作者:By Riemer,Claus Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:1273 卷标:46(7) 页码:1273-1276]

    626-05-1 = 98027-81-7
    反应条件:1.1R:H2O2,S:F3Cco2H,S:H2O2.1R:Hno3,R:H2So4 so3
    标题:4,4'-Donor-Substituted And 6,6'-Difunctionalized 2,2'-Bipyridines
    作者:By Neumann,Uwe And Voegtle,Fritz
    参考文献:Chemische Berichte 日期:1989 卷标:122(3) 页码:589-91]

    626-05-1 = 98027-81-7
    反应条件:1.1R:Cf3Co3H,R:F3Cco2H,R:H2O2,S:H2O2.1R:Hno3,R:H2So4
    标题:New Synthesis Of 2,6-Dibromopyridine N-Oxide
    作者:By Evans,R. F. Et Al
    参考文献:Recueil Des Travaux Chimiques Des Pays-Bas Et De La Belgique 日期:1959 页码:408-11]

    25373-69-7 = 98027-81-7
    反应条件:1.1R:Hno3,S:H2So4
    标题:Derivatives Of Pyridine N-Oxide. Xvi. Mercuration Of Pyridine N-Oxide
    作者:By Van Ammers,M. And Den Hertog,H. J.
    参考文献:Recueil Des Travaux Chimiques Des Pays-Bas Et De La Belgique 日期:1958 页码:340-5
📜2,6-二溴吡啶置于硫酸,硝酸,过氧化脲素,三氟乙酸酐体系中,用 二氯甲烷 作为反应溶剂,化学反应 24.67H,反应生成 2,6-二溴-4-硝基吡啶氮氧化物
参考文献:灵活合成4-氨基-1,3-二氢咪唑并[4,5-C]吡啶-2-酮核的c-6和n-1类似物
标题:灵活合成4-氨基-1,3-二氢咪唑并[4,5-C]吡啶-2-酮核的c-6和n-1类似物
摘要:描述了一种灵活的途径,该途径使得能够获得4-氨基-1,3-二氢咪唑并[4,5-C]吡啶-2-酮的衍生物.原始路线的选择性,反应安全性和低收率问题可以通过对该路线的关键改进加以解决,包括negishi交叉偶联以及使用氨基甲酸酯作为保护基团和固有的羰基来源.新的途径可以改变c-6和n-1取代基.
DOI:10.1016/j.Tetlet.2011.08.119

海关参考信息

专利信息


专利号:US-5929082-A
优先权日:1995-03-24
标 题:Potassium ion channel blockers
发明人：CHAMBERS NOEL JOHN; JOHNSTON GRAHAM ALLEN ROSS
权利人:POLYCHIP PHARMACEUTICALS PTY; UNIV SYDNEY
摘要:PCT No. PCT/AU96/00151 Sec. 371 Date Jan. 23, 1998 Sec. 102(e) Date Jan. 23, 1998 PCT Filed Mar. 21, 1996 PCT Pub. No. WO96/30341 PCT Pub. Date Oct. 3, 1996The invention provides novel sulphonylurea, sulphonylthiourea and sulphonylguanidine compounds which have the ability to block potassium ion channels regulated by intracellular concentrations of ATP. Methods of synthesis, pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes, cardiac arrhythmias, ischaemic and hypoxic cardiovascular incidents, and cancers are also claimed.

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合成参考文献


参考文献:10.1055/s-0039-1689855
摘要:Short Synthesis of the 3-Deazaguanosine RNA Building Block. Synfacts. 2019 Jul 18;15(08):0941. doi: 10.1055/s-0039-1689855.
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