CAS: 87494-13-1; Boc-D-Cys(Trt)-Oh

该化合物是一种合成氨基酸衍生物,通常用于peptide合成和生物化学中,它含有一种乙基-丁基氧碳酸(Boc)保护组,通常用于在化学反应中保护氨基组."三基"的称谓表明,细胞steine残留物的硫醇组受到三基组的保护,加强了化合物的稳定性和溶解性.这种修改允许在不受到硫醇组干扰的情况下有选择地作出反应.D组配置是指氨基酸的立体化学学,这对于生物活动和相互作用十分重要.Bec-S-三基-D-细胞-细胞stestene通常用于ptides合成中,因为需要将细胞steine纳入其中,特别是形成不硫化物结,因此,在各种条件下,它的稳定使得它成为开发基于丙基治疗和研究应用过程中一个有价值的中间体.D组与许多化学物质一样,正确处理和储存是其完整性的基本条件.

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相似化合物

103213-32-7 167015-11-4 21947-98-8

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N-(tert-butyloxycarbonyl) azide S-trityl-L-cysteine triphenylmethyl alcohol 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrileB°C-Cys(Trt)-ONp 16H21NO6S2C16H21NO6S2 N-B°C-S-trityl-L-cys-L-ala-OMe 2PhB°C-Cys(Trt)-Gly-°CH2Ph

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    专利信息


    专利号:US-9388212-B2
    优先权日:2013-02-21
    标 题:Solid phase peptide synthesis via side chain attachment
    发明人:BARLOS KLEOMENIS K
    权利人:CHEMICAL & BIOPHARMACEUTICAL LAB OF PATRAS S A
    摘要:The present application discloses peptides and peptaibols of high purity may be obtained by solid phase peptide synthesis using as the starting resin hydroxy amino acids, hydroxy amino acid amides, hydroxy amino alcohols or small peptides containing hydroxy amino acids attached to polymers through their side chain.

    专利号:US-6841559-B1
    优先权日:1999-11-19
    标 题:Pyridinones to treat and prevent bacterial infections
    发明人:ALMQVIST FREDERIC; EMTENAS HANS; HULTGREN SCOTT J; PINKNER JEROME S
    权利人:WASHINGTON UNIVERSITY OF ST LO
    摘要:Novel pyridinones and their derivatives which are effective in treating or preventing Gram-negative bacterial infections are provided. The pyridinones are stable and easily derivatized; the methods by which these derivatizations occur is described. Two regioselective and functional group tolerant methods for the synthesis of the novel pyridinones are also provided. One such synthetic method involves reacting an imine and a Meldrum's acid derivative in solution. The other synthetic method is a solid phase synthesis of the pyridinones in which an imine is prepared bound to a solid support and a Meldrum's acid derivative is reacted with the imine. Novel imine intermediates useful in the solid phase and solution methods of synthesizing the pyridionones are also described.

    专利号:US-11634741-B2
    优先权日:2013-11-20
    标 题:Synthesis of L-nucleic acids by means of an enzyme
    发明人:PECH ANDREAS; JAROSCH FLORIAN; JAHNZ MICHAEL; KLUSSMANN SVEN; DAVID RALF
    权利人:APTARION BIOTECH AG
    摘要:The present invention is related to a method for adding one or more L-nucleotides to the 3′end of a first L-nucleic acid, wherein the method comprises the step of reacting the one or more L-nucleotides with the first L-nucleic acid in the presence of a protein comprising a mutant enzymatic activity exhibiting moiety, wherein the enzymatic activity is capable of adding one or more L-nucleotides to the 3′ end of the first L-nucleic acid, wherein the mutant enzymatic activity exhibiting moiety comprises an amino acid sequence, wherein the amino acids of the amino acid sequence are D-amino acids, wherein the mutant enzymatic activity exhibiting moiety is a variant of an enzymatic activity exhibiting moiety, wherein the enzymatic activity exhibiting moiety consists of an amino acid sequence according to SEQ ID NO: 15 and wherein the amino acids of the amino acid sequence according to SEQ ID NO: 15 are D-amino acids, wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety differs from the amino acid sequence of the enzymatic activity exhibiting moiety consisting of an amino acid sequence according to SEQ ID NO: 15 at least at one amino acid position, preferably at three amino acid positions, and/or wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety is a truncated form of an amino acid sequence according to SEQ ID NO: 15, and wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety is different from an amino acid sequence according to any of SEQ ID NOs 15 to 22 and 51.

    专利号:US-3795666-A
    优先权日:1969-08-01
    标 题 :Method of synthesizing peptides in the presence of a carbodiimide and of 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine
    发明人:KONIG W; GEIGER R; WOLF E
    权利人:HOECHST AG
    摘要:IMPROVED SYNTHESIS OF PEPTIDES BY THE CARBODIIMIDE METHOD IN WHICH AN AMINO-PROTECTED AMINO ACID OR PEPTIDE HAVING A REACTIVE CARBOXY GROUP IS CONDENSED WITH A CARBOXY-PROTECTED AMINO ACID OR PEPTIDE HAVING A REACTIVE AMINO IN THE PRESENCE OF 3-HYDROXY-4-OXO3,4-DIHYDRO-1,2,3-BENZOTRIAZINE AS WELL AS IN THE PRESENCE OF A CARBODIIMIDE SUCH AS DICYCLOHEXYL CARBODIIMIDE.

    专利号:EP-3071702-B1
    优先权日:2013-11-20
    标题 :Synthesis of l-nucleic acids by means of an enzyme

    专利号:US-2016304926-A1
    优先权日:2013-11-20
    标题:Synthesis of L-Nucleic Acids by Means of an Enzyme
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    合成参考文献


    参考文献:10.1055/s-0037-1612059
    摘要:Katoh T, Narita K, Sayar N, Saijo K, Ishioka C. A Concise Approach for Producing Optically Pure Carboxylic Acid Segments for the Synthesis of Bicyclic Depsipeptide Histone Deacetylase Inhibitors. Synthesis. 2019 Feb 05;51(06):1408–18. doi: 10.1055/s-0037-1612059.
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