氰乙酰胺置于劳森试剂体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 2-氰基硫代乙酰胺 参考文献: Heterocyclic Compounds For The Inhibition Of Pask[fr] Composés Hétérocycliques Pour L'Inhibition De Pask 标题: Heterocyclic Compounds For The Inhibition Of Pask[fr] Composés Hétérocycliques Pour L'Inhibition De Pask 摘要:本文披露了新的杂环化合物和组合物,以及它们作为药物治疗疾病的应用.还提供了抑制pas激酶(pask)在人类或动物主体中活性的方法,用于治疗疾病,如糖尿病.
专利号:US-9917260-B2 优先权日:2013-08-23 标题 :Compounds with terminal heteroarylcyanovinylene groups and their use in organic solar cells 发明人:SUNDARRAJ SUDHAKAR; EICKHOFF CHRISTIAN; BAHULAYAN SHEEJA; SEND ROBERT; NISHIMAE YUICHI; REICHELT HELMUT; TANABE JUNICHI; ERK PETER 权利人:BASF SE 摘要:The present invention relates to a photoactive material comprising a donor substance and an acceptor substance, wherein the donor substance comprises or consists of one or more compounds of formula (I) described herein, or the acceptor substance comprises or consists of one or more compounds of formula (I) described herein, or the donor substance comprises or consists of a first compound of formula (I) described herein and the acceptor substance comprises a second compound of formula (I) described herein with the proviso that the first and second compound are not the same, as well as to an organic solar cell comprising said photoactive material. The present invention also relates to a photoelectric conversion device comprising or consisting of two or more organic solar cells comprising said photoactive material and to compounds of formula (I) as described herein for use as donor substance or as acceptor substance in a photoactive material, Further, the present invention relates to the use of a compound of formula (III) as described herein in the synthesis of a compound of formula (I)as described herein.
专利号:US-2024409557-A1 优先权日:2023-05-09 标 题 :5,6-fused and 6,6-fused bicyclic alcohols and ethers and compositions for use as 15-prostaglandin dehydrogenase modulators 发明人:GREENMAN KEVIN LLOYD; PICKRELL ALEXANDER J; LI KEXUE; AMEGADZIE ALBERT K; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; BOURBEAU MATTHEW P 权利人:AMGEN INC 摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A).Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).
专利号:US-3723448-A 优先权日:1971-06-29 标 题 :N-(4-cyano-1,2,3-thiadizol-5-yl) propionamide 发明人:VOLPP G; DOUNCHIS H 权利人:TMC CORP 摘要:A new chemical compound, of the formula N-(4-cyano-1,2,3thiadiazol-5-yl)propionamide, has selective pre-emergence and post-emergence herbicidal activity. The synthesis of this compound is described, and its utility is exemplified.
专利号:US-9908893-B2 优先权日:2013-06-11 标题 :Thieno [2,3-b] pyridines as multidrug resistance modulators 发明人:KALVINS IVARS; KRAUZE AIVARS; GRINBERGA SIGNE; KRASNOVA LAURA; JASCHENKO ELINA; DOMRACHEVA ILONA; ADLERE ILZE; ANDZANS ZIGMARS; SHESTAKOVA IRINA; DUBURS GUNARS 权利人:LATVIAN INST ORGANIC SYNTHESIS 摘要:The thieno[2,3-b]pyridines of general formula (I), n nwhereinn nR 1 is Me, C 6 H 5 , 3,4,5-(OMe) 3 C 6 H 2 , NH 2 ;n nR 2 is H, CN, COMe, COOC 1-4 alkyl, COOC 2 H 4 OMe, COOC 2 H 4 OPr(n);n nR 3 is C 6 H 4 R 6 , 3,4-OCH 2 O—C 6 H 3 ; 2-furanyl;n R 6 is 4-Cl, 4-NO 2 , 4-N(C 1-4 alkyl) 2 , 3-(C 1-4 alkyloxy), 4-(C 1-4 alkyloxy), 3,4-(C 1-4 alkyloxy) 2 , 3,4,5-(C 1-4 alkyloxy) 3 ;n nR 4 is NH 2 , NHCOMe;n nR 5 is CN, COMe, COC 6 H 4 R 7 ; CO-(2-naphthyl);n R 7 is H, 4-F, 4-Cl, 3-OMe, 4-OMe, 2,4-(OMe) 2 , 3,4,5-(OMe) 3 n nas multidrug resistance modulators to increase the effectiveness of chemotherapy in cancer treatment.
专利号:US-7427625-B2 优先权日:2006-02-08 标 题 :Substituted thiatriazaacenaphthylene-6-carbonitrile kinase inhibitors 发明人:CONNOLLY PETER J; EMANUEL STUART L; HAYDEN STUART; JOHNSON SIGMOND G; LAGU BHARAT; MIDDLETON STEVEN A; PANDEY NIRANJAN B; POWELL MARK T 权利人:JANSSEN PHARMACEUTICA NV 摘要:The present invention is directed to substituted thiatriazaacenaphthylene-6-carbonitrile compounds of formula (I): n nand forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.
专利号:CN-101215269-A 优先权日:2007-12-29 标题 :A kind of 2-thiazolyl acrylonitrile compound and its synthesis method and application
[参考文献]: A Krauze, Et Al. 3,4-Trans-4-Aryl-3-(1-Pyridinio)-1,2,3,4-Tetrahydropyridine-6-Thiolates--New Group Of Potential Cardiotonic Drugs. Eur J Med Chem. 2005 Nov;40(11):1163-7.
合成参考文献
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