专利号:US-4638032-A 优先权日:1983-12-12 标 题 :Magnetic particles as supports for organic synthesis 发明人:BENNER STEVEN A 权利人:GENETICS INST 摘要:A support system for organic synthesis comprising magnetic particles in a dispersion medium covalently attached to functional groups having affinity for polymer subunits, and methods for making and using the support system, e.g. for synthesis of oligodeoxynucleotides and polypeptides.
专利号:US-6251280-B1 优先权日:1999-09-15 标 题 :Imprint-coating synthesis of selective functionalized ordered mesoporous sorbents for separation and sensors 发明人:DAI SHENG; BURLEIGH MARK C; SHIN YONGSOON 权利人:UNIV TENNESSEE RES CORP; U T BATTELLE LLC 摘要:The present invention relates generally to mesoporous sorbent materials having high capacity, high selectivity, fast kinetics, and molecular recognition capability. The invention also relates to a process for preparing these mesoporous substrates through molecular imprinting techniques which differ from convention techniques in that a template molecule is bound to one end of bifunctional ligands to form a complex prior to binding of the bifunctional ligands to the substrate. The present invention also relates to methods of using the mesoporous sorbent materials, for example, in the separation of toxic metals from process effluents, paints, and other samples; detection of target molecules, such as amino acids, drugs, herbicides, fertilizers, and TNT, in samples; separation and/or detection of substances using chromatography; imaging agents; sensors; coatings; and composites.
专利号:US-6733828-B2 优先权日:2002-01-29 标 题 :Method of fabricating nanostructured materials 发明人:CHAO KUEI-JUNG; YANG CHIA-MIN 摘要:A method of confined synthesis of nanostructured material inside a mesoporous material. The method includes the step of providing mesoporous material having uniform and ordered mesopores. Next, a monolayer of charged functional group is attached on the pore surface of mesoporous host material by reacting with functional molecule. A oppositely-charged molecule is incorporated into the confined space of mesoporous material by either ion exchange or incipient wetness impregnation. Finally, the incorporated molecule is reduced or oxidized or further reacted with secondarily-incorporated molecule to form nanostructured material in mesoporous material.
专利号:US-7129308-B2 优先权日:1998-10-13 标题 :Functionalized silicon compounds and methods for their synthesis and use 发明人:MCGALL GLENN; FORMAN JONATHAN ERIC 权利人:AFFYMETRIX INC 摘要:Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino, carboxyl and thiol, as well as modified forms thereof, such as activated or protected forms. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces which may be used in a wide range of different applications. In one embodiment, the silicon compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, to provide a functionalized surface on the substrate, to which molecules, including polypeptides and nucleic acids, may be attached. In one embodiment, after covalent attachment of a functionalized silicon compound to the surface of a solid silica substrate to form a functionalized coating on the substrate, an array of nucleic acids may be covalently attached to the substrate. Thus, the method permits the formation of high density arrays of nucleic acids immobilized on a substrate, which may be used, for example, in conducting high volume nucleic acid hybridization assays.