CAS: 683239-16-9; 20-(Tert-Butoxy)-20-Oxoicosanoic Acid

相似化合物

1767-98-2 843666-40-0 1642333-05-8

1,20-Eicosanedioyl Dichloride置于吡啶,水体系中,用 二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 5.0H,反应生成 二十烷二酸单叔丁酯
参考文献:一种制备脂肪二酸衍生物的方法及其应用
标题:一种制备脂肪二酸衍生物的方法及其应用
摘要:本发明公开了一种制备脂肪二酸衍生物的方法及其应用.该方法是先将长链脂肪二酸和二氯亚砜反应,得到酰氯;将酰氯与叔丁醇反应,再去除氯基团,得到长链脂肪二酸一叔丁酯;接着和n‑羟基琥珀酰亚胺反应,长链脂肪二酸琥珀酰亚胺基叔丁基酯;接着与l‑谷氨酸‑1‑叔丁酯反应,得到叔丁基长链脂肪二酰基‑l‑glu‑otbu;再与n‑羟基琥珀酰亚胺反应,得到叔丁基长链脂肪二酰基‑l‑glu(Osu)‑otbu;最后将叔丁基长链脂肪二酰基‑l‑glu(Osu)‑otbu中的叔丁基去除,得到长链脂肪二酸衍生物.该方法的路线操作简便,质量可控,适合工业放大生产,且成本低,同时纯化简单,适合用于制备高纯度的胰岛素类似物.

专利信息

专利号:WO-2025052429-A1
优先权日:2023-09-04
标 题 :An improved process for the preparation of tirzepatide
发明人：SIRIPRAGADA MAHENDER RAO; GANDAVADI SUNIL KUMAR; PARUMANCHALA SHAIK SHAVALI; TELAKALA HEMA SUNDARA RAO; SHAIK KALESHA
权利人:NEULAND LABORATORIES LTD
摘要:An improved process for the preparation of Tirzepatide having the chemical structural Formula I. The present invention also relates to the compounds of SEQ ID NO. 1 to 14 or a pharmaceutically acceptable salt thereof for use in the synthesis of Tirzepatide or a pharmaceutically acceptable salt thereof. The present invention further relates to the intermediate compounds of Formulae II to Formulae XVIII and its process of preparation, which are used in the preparation of Tirzepatide or a pharmaceutically acceptable salt thereof.

专利号:US-9732137-B2
优先权日:2007-12-28
标 题 :Semi-recombinant preparation of GLP-1 analogues
发明人：LAU JESPER FAERGEMAN; ANDERSEN ASSER SLOTH; BLOCH PAW; LAU JESPER; GARIBAY PATRICK WILLIAM; KRUSE THOMAS; NØRBY INGA SIG NIELSEN; JESSEN CLAUS ULRICH; CHRISTENSEN CASPAR; NORRILD JENS CHRISTIAN
权利人:LAU JESPER FAERGEMAN; ANDERSEN ASSER SLOTH; BLOCH PAW; LAU JESPER; GARIBAY PATRICK WILLIAM; KRUSE THOMAS; NØRBY INGA SIG NIELSEN; JESSEN CLAUS ULRICH; CHRISTENSEN CASPAR; NORRILD JENS CHRISTIAN; NOVO NORDISK AS
摘要:A semi-recombinant method for the production of GLP-1 analogues and derivatives with non-proteogenic amino acids in the N-terminal part combining the use of recombinant expression techniques and chemical peptide synthesis.

专利号:CN-117986347-A
优先权日:2023-12-29
标题 :Synthesis method of canagliptin

专利号:CN-117106055-A
优先权日:2023-08-18
标题 :A kind of synthesis method of tilpotide

专利号:CN-119823233-A
优先权日:2025-03-18
标题:Synthesis method of retaglutide and retaglutide

专利号:CN-119462375-A
优先权日:2024-12-06
标 题 :Synthesis method and application of long-chain alkane diacid mono-tert-butyl ester