CAS: 6651-43-0; (Buta-1,3-Dien-1-Yloxy)Trimethylsilane

相似化合物

6213-94-1 6651-34-9 82223-91-4

上下游产品

chloro-trimethyl-silane trans-Crotonaldehyde 3-butenal 1,2-epoxy-1-trimethylsilyl-but-3-ene 3-Trimethylsilanyloxy-cyclohexa-1,4-diene-1,2-dicarboxylic acid dimethyl ester 6-methylcyclohexa-1,3-diene-1-carbaldehyde (E)-5-ethoxy-5-(p-methyoxyphenyl)-2-pentenal (E)-6-oxohept-2-enal

📜1,2-Epoxy-1-Trimethylsilyl-But-3-Ene 在 Palladium Diacetate,三异丙基亚磷酸酯体系中,用 四氢呋喃作为反应溶剂,获得 1-(Trimethylsiloxy)-1,3-Butadiene
参考文献:在α-三烷基甲硅烷基-β,γ-不饱和醛上立体选择性地添加亲核试剂
标题:在α-三烷基甲硅烷基-β,γ-不饱和醛上立体选择性地添加亲核试剂
摘要:钯(0)催化的硅取代的乙烯基氧杂环戊烷的重排取决于三烷基甲硅烷基的大小.在α-三烷基甲硅烷基-β,γ-不饱和醛上添加有机锂或格氏试剂可为相应的醇提供非对映选择性(De = 54-; 98%)
Doi:10.1016/0040-4039(95)00084-P

专利信息

专利号:US-7888337-B2
优先权日:2007-08-31
标 题 :Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity
发明人：WONG CHI-HUEY; FANG JIM-MIN; SHIE JIUN-JIE; CHENG YIH-SHYUN EDMOND; JAN JIA-TSRONG
权利人:ACADEMIA SINICA
摘要:Novel phosphonate compounds are described. The compounds have activity as neuraminidase inhibitors against wild-type and H274Y mutant of H1N1 and H5N1 viruses. The present disclosure also provides an enantioselective synthetic route to known neuraminidase inhibitors oseltamivir and the anti-flu drug Tamiflu®, as well as novel phosphonate compounds, via D-xylose. Another efficient and flexible synthesis of Tamiflu and the highly potent neuraminidase inhibitor Tamiphosphor was also achieved in 11 steps and >20% overall yields from the readily available fermentation product (1S-cis)-3-bromo-3,5 -cyclohexadiene-1,2-diol. Most of the reaction intermediates were obtained as crystals without tedious purification procedures. The key transformations include an initial regio- and stereoselective bromoamidation of a bromoarene cis-dihydrodiol, as well as the final palladium-catalyzed carbonylation and phosphonylation.

专利号:US-5097051-A
优先权日:1989-02-10
标题 :Cyclic triketone compounds and trimethylsilyloxy butadiene compounds and their use in the preparation of daunomycinone derivatives
发明人：SCHEEREN JOHAN W; DEBIE JOANNES F M; DEVOS DIRK
权利人:PHARMACHEMIE BV
摘要:The invention provides novel cyclic triketone compounds of the formulae wherein S is H, alkyl or alkoxy and R* is a group of the formule wherein R<1> is methyl and R2 is an alkyl group containing at least 2 carbon atoms, or R<1> is an alkyl group having 1-4 carbon atoms and R<2> is an aryl group, a hetero aryl group, a -CH2OR min , a -CH2N @@ group, a -CH2SR sec group or a -CH2CH=CH2 group, wherein R min and R sec are alkyl groups having 1-4 carbon atoms. These compounds can be used for preparing daunomycinone and derivatives thereof. Daunomycinone is used for preparing daunomycin and adriamycin. By introducing chirality at C-1 of ring A in the preparation of said novel compounds by using a novel diene of formula (1) in a Diels-Alder reaction for said preparation, the chirality of C-3 is established in the subsequent reaction with LiC IDENTICAL CSi(CH3)3 in the synthesis of daunomycinone and derivatives thereof. This last reaction leads to the desired compound wherein OH at C-3 and OR at C-1 are in the cis-position with respect to each other.

专利号:US-5183913-A
优先权日:1989-02-10
标 题 :Cyclic triketone compounds and trimethylsilyoxy butadiene compounds and their use in the preparation of daunomycinone derivatives
发明人：SCHEEREN JOHAN W; MARTINUS DE BIE JOANNES F; DE VOS DIRK
权利人:PHARMACHEMIE BV
摘要:The invention provides novel cyclic triketone compounds of the formulae (2) (3) wherein S is H, alkyl or alkoxy and R* is a group of the formule wherein R1 is methyl and R2 is an alkyl group containing at least 2 carbon atoms or R1 is an alkyl group having 1-4 carbon atoms and R2 is an aryl group, a hetero aryl group, a -CH2OR' group, a -CH2N (1) This last reaction leads to the desired compound wherein OH at C-3 and OR at C-1 are in the cis-position with respect to each other.

专利号:US-4087465-A
优先权日:1976-02-25
标题:Process for the preparation of halogeno-acetals from enoxysilanes
发明人：DECOR JEAN-PIERRE
权利人:RHONE POULENC IND
摘要:Halogeno-acetals of ethylenic aldehydes are made by reaction of a corresponding enoxysilane compound with a halogen cation and an alcohol. The products are useful inter alia in the synthesis of retinal and other unsaturated aldehydes.

专利号:US-2010113397-A1
优先权日:2007-08-31
标 题 :Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity

专利号:US-5220003-A
优先权日:1991-03-29
标题 :Process for the synthesis of 2',3'-dideoxynucleosides
发明人：JUNG MICHAEL E; GARDINER JOHN M
权利人:UNIV CALIFORNIA
摘要:Methods are provided for preparing 3'-substituted-2',3'-dideoxynucleosides, and the like, from non-carbohydrate, non-nucleoside starting materials.