CAS: 655-05-0; 2-(Dimethylamino)-5-Phenyl-1,3-Oxazol-4-One

上下游产品

匹莫林 2-Amino-5-Phenyl-4-Oxazolinone 2152-34-3

📜Dl-扁桃酸甲酯置于氨,1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,用 甲醇,二氯甲烷 作为反应溶剂,化学反应 2.0H,反应生成 托扎啉酮
参考文献:Condensation Of Vilsmeier Salts,Derived From Tetraalkylureas,With α-Hydroxy Amide Derivatives: One-Pot Approach To Synthesize 2-Dialkylamino-2-Oxazolin-4-Ones
标题:Condensation Of Vilsmeier Salts,Derived From Tetraalkylureas,With α-Hydroxy Amide Derivatives: One-Pot Approach To Synthesize 2-Dialkylamino-2-Oxazolin-4-Ones
摘要:本研究开发了一种新颖而简单的合成方法,可从各种维尔斯梅尔盐和α-羟基酰胺衍生物中合成 2-二烷基氨基-2-恶唑啉-4-酮.值得注意的是,噻嗪酮(3A)是一种用于治疗三联症和厌食症的温和兴奋剂,采用这种方法可以简单,高产地合成.
DOI:10.1246/cl.161006

专利信息

专利号:US-7576211-B2
优先权日:2004-09-30
标题 :Synthesis of thienopyridinone compounds and related intermediates
发明人：DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; CHEN DONGLI; MARANTZ YAEL; SHACHAM SHARON; HEIFETZ ALEXANDER; INBAL BOAZ; BAR-HAIM SHAY; MOHANTY PRADYUMNA; LOBERA MERCEDES; WU LAURENCE
权利人:EPIX DELAWARE INC
摘要:The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

专利号:US-2006084805-A1
优先权日:2004-09-30
标题:Synthesis of thienopyridinone compounds and related intermediates

专利号:US-7982040-B2
优先权日:2004-05-17
标题 :Thienopyridinone compounds and methods of treatment
发明人：DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; MOHANTY PRADYUMNA; CHEN DONGLI; LOBERA MERCEDES; WU LAURENCE; MARANTZ YAEL; INBAL BOAZ; HEIFETZ ALEXANDER; BAR-HAIM SHAY; SHACHAM SHARON
权利人:NANOTHERAPEUTICS INC
摘要:The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

专利号:CA-2555219-A1
优先权日:2004-02-03
标 题 :Synthesis of cyanoimino-benzoimidazoles

专利号:WO-2005075459-A1
优先权日:2004-02-03
标题:Synthesis of cyanoimino-benzoimidazoles