CAS: 627-31-6; 1,3-Diiodopropane

该化合物是一种有机化合物,被归类为二卤烷,具体而言,是一种线性链分子,其两个碘原子附于三碳丙烷链第一和第二碳原子,其分子式为C3H6I2,与其他卤化碳化合物相比,其沸点相对较低,这表明其分子重量和结构.碘原子的存在有助于其再活性,使其成为有机合成的有用中间体,特别是在碳-碳联结的形成和各种替代反应中. 1,3-二碘丙烷在室温下一般是淡黄色液体的无色,在水中不溶,但在有机溶剂中溶解.由于存在碘,它可以表现出某种程度的毒性,应当按照适当的安全规程加以谨慎处理.它的应用范围扩大到医药化学和材料科学等领域,可以作为更复杂的分子的建筑块.

结构式图片

相似化合物

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欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

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合成工艺路线路线简述

    1,3-丙二醇-二-间-甲苯磺酸盐置于sodium Iodide体系中,用 丙酮 作为反应溶剂,化学反应生成 1,3-二碘丙烷
    参考文献:Lichtenberger,J.; Tritsch,P.,Bulletin De La Societe Chimique De France,1961,P. 369-371
    标题:Lichtenberger,J.; Tritsch,P.,Bulletin De La Societe Chimique De France,1961,P. 369-371

    专利信息


    专利号:US-10364220-B2
    优先权日:2012-12-21
    标题:Synthesis of succinimides and quaternary ammonium ions for use in making molecular sieves
    发明人:SCHMITT KIRK D; ZUSHMA STEPHEN; BURTON ALLEN W
    权利人:EXXONMOBIL CHEMICAL PATENTS INC
    摘要:The present invention relates to the synthesis of succinimides, in particular to a method for the synthesis of a succinimide compound, comprising the step of reacting an alkyne, with carbon monoxide and ammonia or an amine, in the presence of an iron catalyst, wherein the reaction is carried out in an amine liquid phase and/or in the absence of an ether solvent. The succinimides may be reduced to quaternary ammonium cations which may be used as structure directing agents in the synthesis of molecular sieves.

    专利号:US-7557099-B2
    优先权日:2004-03-01
    标题 :Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines
    发明人:HOWARD PHILIP WILSON; KANG GYOUNG-DONG
    权利人:SPIROGEN LTD
    摘要:Compounds and a method of synthesis of compounds of formula (Ia) or (Ib): and salts, solvates, and chemically protected forms thereof, wherein the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R 2 and R 3 are independently selected from —H, â•?O, â•?CH 2 , —CN, —R, OR, halo, â•?CH—R, O—SO 2 —R, CO 2 R and COR; R 10 is a carbamate-based nitrogen protecting group; and R 11 is an oxygen protecting group.

    专利号:US-9005573-B2
    优先权日:2011-12-22
    标 题:Layered conversion synthesis of zeolites
    发明人:NICHOLAS CHRISTOPHER P; MILLER MARK A
    权利人:UOP LLC
    摘要:A new synthesis technique has been developed to prepare a family of coherently grown composites of at least two zeotypes. Examples of these composites are represented by the empirical formula.n nNa n M m k+ T t Al 1-x E x Si y O z n nwhere “nâ€? is the mole ratio of Na to (Al+E), M represents at least one metal of zinc, Group 1, Group 2, Group 3 and the lanthanide series of the periodic table, and any combination thereof, “mâ€? is the mole ratio of M to (Al+E), “kâ€? is the average charge of the metal or metals M, T is the organic structure directing agent or agents, “tâ€? is the mole ratio of N from the organic structure directing agent or agents to (Al+E), and E is a framework element such as gallium. The synthesis technique is the Layered Conversion Synthesis technique.

    专利号:US-6906046-B2
    优先权日:2000-12-22
    标题 :Pharmaceutical uses and synthesis of benzobicyclooctanes
    发明人:JACKSON RANDY W; DARWISH IHAB; BAUGHMAN TED A; HOWBERT J JEFFRY
    权利人:CELLTECH R & D INC
    摘要:Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual compounds.

    专利号:US-11920040-B2
    优先权日:2018-05-29
    标 题 :Carborhodamine compounds and methods of preparation thereof
    发明人:LUKHTANOV EUGENY A
    权利人:ELITECHGROUP MDX LLC
    摘要:The carborhodamine dyes disclosed herein are novel reagents suitable for automated incorporation of carborhodamine dyes into oligonucleotides that can be used in detection methods for nucleic acid targets. This disclosure provides an efficient and simple process for the preparation of carborhodamine compounds and introduces previously unknown reagents for the automated synthesis of oligonucleotide-carborhodamine conjugates.

    专利号:US-2015158020-A1
    优先权日:2013-12-11
    标题:Synthesis of zeolites using an organoammonium compound
    发明人:NICHOLAS CHRISTOPHER P; MILLER MARK A
    权利人:UOP LLC
    摘要:A method for synthesizing a zeolite includes the steps of: (a) preparing an aqueous mixture comprising water, a substituted hydrocarbon and an amine; (b) reacting the aqueous mixture; (c) obtaining a solution comprising an organoammonium product; (d) forming a reaction mixture including reactive sources of M, Al, Si, optionally seeds of a layered material L, and the solution, wherein M is a metal; and (e) heating the reaction mixture to form the zeolite. The substituted hydrocarbon can be an α,ω-dihalogen substituted alkane, and the amine is preferably essentially incapable of undergoing pyramidal inversion.
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    主要参考文献

    参考标题:The Asymmetric Synthesis Of Amines Via Nickel-Catalyzed Enantioconvergent Substitution Reactions
    作者:Ze-Peng Yang,Dylan J. Freas,Gregory C. Fu |发布日期:2021.2.24
    摘要:Dialkyl Carbinamines Do Not Provide General Access To Amines Wherein The Two Alkyl Groups Are Of Similar Size (E.G., Ch2R Versus Ch2R1). Herein, We Report Two Mild Methods For The Catalytic Enantioconvergent Synthesis Of Protected Dialkyl Carbinamines, Both Of Which Use A Chiral Nickel Catalyst To Couple An Alkylzinc Reagent (1.1-1.2 Equiv) With A Racemic Partner, Specifically, An α-Phthalimido Alkyl Chloride

    合成参考文献


    摘要:Demchuk, O. M.; Stankevič, M.; Pietrusiewicz, K. M., Science of Synthesis Knowledge Updates, (2015) 1, 352.
    摘要:Witt, D., Science of Synthesis Knowledge Updates, (2019) 2, 269.
    摘要:Clark, K. F.; Dimitrova, D.; Murphy, J. A., Science of Synthesis, (2020) , 2.
    参考文献:10.1385/1-59259-676-2:49
    摘要:Wang Z, Rana TM. Probing RNA-protein interactions by psoralen photocrosslinking. Methods Mol Biol. 1999;118():49–62. doi: 10.1385/1-59259-676-2:49.
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