1,3-丙二醇-二-间-甲苯磺酸盐置于sodium Iodide体系中,用 丙酮 作为反应溶剂,化学反应生成 1,3-二碘丙烷 参考文献:Lichtenberger,J.; Tritsch,P.,Bulletin De La Societe Chimique De France,1961,P. 369-371 标题:Lichtenberger,J.; Tritsch,P.,Bulletin De La Societe Chimique De France,1961,P. 369-371
专利信息
专利号:US-10364220-B2 优先权日:2012-12-21 标题:Synthesis of succinimides and quaternary ammonium ions for use in making molecular sieves 发明人:SCHMITT KIRK D; ZUSHMA STEPHEN; BURTON ALLEN W 权利人:EXXONMOBIL CHEMICAL PATENTS INC 摘要:The present invention relates to the synthesis of succinimides, in particular to a method for the synthesis of a succinimide compound, comprising the step of reacting an alkyne, with carbon monoxide and ammonia or an amine, in the presence of an iron catalyst, wherein the reaction is carried out in an amine liquid phase and/or in the absence of an ether solvent. The succinimides may be reduced to quaternary ammonium cations which may be used as structure directing agents in the synthesis of molecular sieves.
专利号:US-7557099-B2 优先权日:2004-03-01 标题 :Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines 发明人:HOWARD PHILIP WILSON; KANG GYOUNG-DONG 权利人:SPIROGEN LTD 摘要:Compounds and a method of synthesis of compounds of formula (Ia) or (Ib): and salts, solvates, and chemically protected forms thereof, wherein the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R 2 and R 3 are independently selected from —H, â•?O, â•?CH 2 , —CN, —R, OR, halo, â•?CH—R, O—SO 2 —R, CO 2 R and COR; R 10 is a carbamate-based nitrogen protecting group; and R 11 is an oxygen protecting group.
专利号:US-9005573-B2 优先权日:2011-12-22 标 题:Layered conversion synthesis of zeolites 发明人:NICHOLAS CHRISTOPHER P; MILLER MARK A 权利人:UOP LLC 摘要:A new synthesis technique has been developed to prepare a family of coherently grown composites of at least two zeotypes. Examples of these composites are represented by the empirical formula.n nNa n M m k+ T t Al 1-x E x Si y O z n nwhere “nâ€? is the mole ratio of Na to (Al+E), M represents at least one metal of zinc, Group 1, Group 2, Group 3 and the lanthanide series of the periodic table, and any combination thereof, “mâ€? is the mole ratio of M to (Al+E), “kâ€? is the average charge of the metal or metals M, T is the organic structure directing agent or agents, “tâ€? is the mole ratio of N from the organic structure directing agent or agents to (Al+E), and E is a framework element such as gallium. The synthesis technique is the Layered Conversion Synthesis technique.
专利号:US-6906046-B2 优先权日:2000-12-22 标题 :Pharmaceutical uses and synthesis of benzobicyclooctanes 发明人:JACKSON RANDY W; DARWISH IHAB; BAUGHMAN TED A; HOWBERT J JEFFRY 权利人:CELLTECH R & D INC 摘要:Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual compounds.
专利号:US-11920040-B2 优先权日:2018-05-29 标 题 :Carborhodamine compounds and methods of preparation thereof 发明人:LUKHTANOV EUGENY A 权利人:ELITECHGROUP MDX LLC 摘要:The carborhodamine dyes disclosed herein are novel reagents suitable for automated incorporation of carborhodamine dyes into oligonucleotides that can be used in detection methods for nucleic acid targets. This disclosure provides an efficient and simple process for the preparation of carborhodamine compounds and introduces previously unknown reagents for the automated synthesis of oligonucleotide-carborhodamine conjugates.
专利号:US-2015158020-A1 优先权日:2013-12-11 标题:Synthesis of zeolites using an organoammonium compound 发明人:NICHOLAS CHRISTOPHER P; MILLER MARK A 权利人:UOP LLC 摘要:A method for synthesizing a zeolite includes the steps of: (a) preparing an aqueous mixture comprising water, a substituted hydrocarbon and an amine; (b) reacting the aqueous mixture; (c) obtaining a solution comprising an organoammonium product; (d) forming a reaction mixture including reactive sources of M, Al, Si, optionally seeds of a layered material L, and the solution, wherein M is a metal; and (e) heating the reaction mixture to form the zeolite. The substituted hydrocarbon can be an α,ω-dihalogen substituted alkane, and the amine is preferably essentially incapable of undergoing pyramidal inversion.
参考标题:The Asymmetric Synthesis Of Amines Via Nickel-Catalyzed Enantioconvergent Substitution Reactions 作者:Ze-Peng Yang,Dylan J. Freas,Gregory C. Fu |发布日期:2021.2.24 摘要:Dialkyl Carbinamines Do Not Provide General Access To Amines Wherein The Two Alkyl Groups Are Of Similar Size (E.G., Ch2R Versus Ch2R1). Herein, We Report Two Mild Methods For The Catalytic Enantioconvergent Synthesis Of Protected Dialkyl Carbinamines, Both Of Which Use A Chiral Nickel Catalyst To Couple An Alkylzinc Reagent (1.1-1.2 Equiv) With A Racemic Partner, Specifically, An α-Phthalimido Alkyl Chloride
合成参考文献
摘要:Demchuk, O. M.; Stankevič, M.; Pietrusiewicz, K. M., Science of Synthesis Knowledge Updates, (2015) 1, 352. 摘要:Witt, D., Science of Synthesis Knowledge Updates, (2019) 2, 269. 摘要:Clark, K. F.; Dimitrova, D.; Murphy, J. A., Science of Synthesis, (2020) , 2. 参考文献:10.1385/1-59259-676-2:49 摘要:Wang Z, Rana TM. Probing RNA-protein interactions by psoralen photocrosslinking. Methods Mol Biol. 1999;118():49–62. doi: 10.1385/1-59259-676-2:49.